A5084996082- Heart Failure Treatment and Management
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Studies
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Signaling Pathways in Disease
- IL-33, ST2, and ILC Pathways
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Hebei Medical University
2023
Xingtai People's Hospital
2023
Circulating proteomic signatures of age are closely associated with aging and age-related diseases; however, the utility changes in secreted proteins identifying therapeutic targets for diseases remains unclear. Serum profiling an age-stratified healthy population further community-based cohort together heart failure patients study demonstrated that circulating C-C motif chemokine ligand 17 (CCL17) level increased correlated cardiac dysfunction. Subsequent animal experiments revealed...
Background: Coronary thrombosis events continue to be the leading cause of morbidity and mortality worldwide. Recently, emerging evidence has highlighted role gut microbiota in cardiovascular disease, but few studies have systematically investigated variation associated with atherothrombosis. Methods: We conducted multi-omics analysis (metagenomics sequencing serum metabolomics) on 146 subjects from Peking Union Medical College Hospital-Coronary Artery Disease (PUMCH-CAD) cohort. analyzed...
Analyzing the genetic variation and mRNA expression of interleukin-17A (IL-17A) gene its impact on asthma susceptibility was purpose this study. 120 patients were selected as group, another healthy individuals who underwent physical examination health group; Compare cytokine levels IL-17A between two groups, well clinical indicator total immunoglobulin E (TIgE) levels; The genotype allele distribution frequency Single-nucleotide polymorphism locus rs2275913 rs8193036 compared groups; serum...