A5017839481- Hepatitis B Virus Studies
- Supercapacitor Materials and Fabrication
- Hepatitis C virus research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Conducting polymers and applications
- Fuel Cells and Related Materials
- Circular RNAs in diseases
- Advanced Battery Materials and Technologies
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- RNA modifications and cancer
- Advanced battery technologies research
- Electrocatalysts for Energy Conversion
- Photochemistry and Electron Transfer Studies
- Graphene research and applications
- Advancements in Battery Materials
- DNA and Nucleic Acid Chemistry
- Membrane-based Ion Separation Techniques
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Cervical Cancer and HPV Research
- Alcohol Consumption and Health Effects
- Galectins and Cancer Biology
Institute of Post Graduate Medical Education and Research
2016-2025
Harcourt Butler Technical University
2023-2024
Institute for Postgraduate Medical Education
2024
Ames National Laboratory
2022-2023
Iowa State University
2021-2022
Midlands Partnership NHS Foundation Trust
2022
Indian Institute of Technology Kanpur
2014-2020
ChromoLogic (United States)
2018-2019
Indraprastha Apollo Hospitals
2015
S.N. Bose National Centre for Basic Sciences
2011-2014
Increasing significance of tumor-stromal interaction in development and progression cancer implies that signaling molecules the tumor microenvironment (TME) might be effective therapeutic targets for hepatocellular carcinoma (HCC). Here, role microRNA miR-199a-3p regulation TME HCC has been investigated by several vitro vivo assays. Expression was observed significantly low tissues its overexpression remarkably inhibited growth metastasis to lung NOD-SCID mice. In restoration expression...
Abstract Diagnosis of hepatocellular carcinoma (HCC) remains challenging to clinicians, particularly in a patient with low alpha‐fetoprotein. Here, silico, ex vivo and vitro data were combined identify liver‐specific exosomal miRNAs as an early diagnostic marker for HCC. Transcriptome profiling mRNA small RNA same HCV‐HCC normal liver tissues followed by cross‐validation 41 deregulated (log 2 FoldChange > 1.5, P adj < .1) GEO/TCGA datasets HCV/HBV related HCC vs normal/adjacent tissue...
Different types of gross chromosomal rearrangements (GCRs), including translocations, interstitial deletions, terminal deletions with de novo telomere additions, and chromosome fusions, are observed in many cancers. Multiple pathways, such as S-phase checkpoints, DNA replication, recombination, chromatin remodeling, maintenance that suppress GCRs have been identified. To experimentally expand our knowledge other pathway(s) GCRs, we developed a generally applicable genome-wide screening...
With properties such as stability to long-term storage and amenability repetitive use, nucleic acid aptamers are compatible with many sensing/transducing platforms intended for use in remote locations. Sensors these important quickly identifying ebolavirus outbreaks, which frequently start locations that lack sophisticated equipment. Soluble glycoprotein (sGP), an excellent biomarker ebolaviruses, is produced from the same gene GP1,2 decorates surface of viral particle secreted abundance...
Controversies about the origin of circulating miRNAs have encouraged us to identify organ specific as disease biomarkers. To liver-specific for hepatocellular carcinoma (HCC), global expression profiling in liver tissue HBV-HCC and HBV-control with no or mild fibrosis was evaluated. A total 40 differentially expressed were identified HCC. Among ten highly altered miRNAs, six successfully validated tissues, whereas only two miR-126 miR-142-3p showed increased plasma compared HBV-non-HCC...
Summary Background CD4 + regulatory T‐cells (Tregs) expand during chronic hepatitis B virus (HBV) infection and inhibit antiviral immunity, although the underlying mechanism remains largely elusive. Myeloid‐derived suppressor cells (MDSC) have been linked with T‐cell dysfunction but questions remain regarding their persistence/profile/function in chronically HBV infected patients. Aim To characterise MDSC different phases of namely, immune‐tolerant (IT), e‐antigen‐positive (EP‐CHB), inactive...
Abstract Background and Aims Chronic HBV infection (CHI) is associated with a diverse natural history that includes immune‐tolerant (IT), HBeAg‐positive chronic hepatitis B (CHB) (EP‐CHB), inactive carrier, HBeAg‐negative CHB (EN‐CHB) phases. A hallmark of CHI impairment HBV‐specific T‐cell response. Recently, myeloid‐derived suppressor cells (MDSCs) have emerged as key regulator T cells, their properties are sculpted by microenvironment. Here, we investigated the distinctive features MDSCs...
Genome diversity is a hallmark of hepatitis B virus (HBV), which allowed its classification into 10 genotypes (A-J) and numerous subgenotypes. Among them, Genotype D currently segregated eight subgenotypes (D1-D8). Here, we report the identification characterization novel subgenotype within genotype HBV from chronic e antigen (HBeAg)-negative patients Eastern India. Phylogenetic tree analysis based on complete genome sequences revealed that six 39 HBV/D isolates formed distinct cluster...
Proton exchange membrane (PEM) fuel cell receives special attention as an alternative power device for various industrial applications because of its excellent energy conversion efficiency, high density, low operating temperature, convenient supply, longer life time and emission. The prospective commercial PEM comprise laptop, computers, cellular phones, military back packs, scooters, cars, etc. However, the production cost long term durability hinder commercialization cell. Bipolar plate is...
Nickel particles were deposited on carbon fiber (CF) via a facile electroless coating method at various times intended for advanced structural application. Scanning electron microscopy demonstrates that, with progressive coating, particle size and density of Ni over the CF surface increase. The influence modification time static dynamic mechanical properties CF-reinforced epoxy hybrid composites was investigated by short beam, flexural test, dynamical analysis. Results summarize that...