A5044123218- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer Cells and Metastasis
- Toxin Mechanisms and Immunotoxins
- Lipid Membrane Structure and Behavior
- Glycosylation and Glycoproteins Research
- Chronic Kidney Disease and Diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Fibrosis and Remodeling
- Eicosanoids and Hypertension Pharmacology
- Blood groups and transfusion
- Inflammatory Bowel Disease
Institute of Post Graduate Medical Education and Research
2015-2024
Roswell Park Comprehensive Cancer Center
1978
Abstract Diagnosis of hepatocellular carcinoma (HCC) remains challenging to clinicians, particularly in a patient with low alpha‐fetoprotein. Here, silico, ex vivo and vitro data were combined identify liver‐specific exosomal miRNAs as an early diagnostic marker for HCC. Transcriptome profiling mRNA small RNA same HCV‐HCC normal liver tissues followed by cross‐validation 41 deregulated (log 2 FoldChange > 1.5, P adj < .1) GEO/TCGA datasets HCV/HBV related HCC vs normal/adjacent tissue...
Genome diversity is a hallmark of hepatitis B virus (HBV), which allowed its classification into 10 genotypes (A-J) and numerous subgenotypes. Among them, Genotype D currently segregated eight subgenotypes (D1-D8). Here, we report the identification characterization novel subgenotype within genotype HBV from chronic e antigen (HBeAg)-negative patients Eastern India. Phylogenetic tree analysis based on complete genome sequences revealed that six 39 HBV/D isolates formed distinct cluster...
An important driving force behind the sequence diversity of hepatitis B virus (HBV) is viral adaptation to host immune responses. To gain an insight into impact immunity on genetic diversification and properties HBV, we characterized HBV genotype D from treatment-naive e antigen-positive (EP) antigen-negative (EN) patients with chronic (CHB), where under stronger pressure, that derived human immunodeficiency (HIV)/HBV-coinfected individuals, HIV infection has significantly weakened system....
Chronic hepatitis C virus (HCV) infection is a leading cause of end-stage liver diseases, such as fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Several cellular entities, including paraspeckles their related components, are involved in viral pathogenesis cancer progression. NEAT1 lncRNA major component that has been linked to several malignancies. In this study, analysis the Cancer Genome Atlas (TCGA) database validation HCV-induced HCC tissue serum samples showed significantly...
Abstract Diverse mechanisms have been established to understand the chemoresistance of hepatocellular carcinoma (HCC), but contribution non-coding RNAs is not surveyed well. Here, we aimed explore lncRNA-miRNA axis in Hepatitis C and B virus (HCV HBV) infected HCC investigate molecular mechanism identify a potential therapeutic target for HCC. The small RNA transcriptome analysis followed by qRT-PCR validation with liver tissues both HCV HBV patients revealed that miR-424-5p, miR-136-3p,...
The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with complement-components during chronic HBV infection remains largely unknown. We investigated mechanism by which inhibits formation cytolytic membrane-attack complex (MAC) and studied its impact on MAC-mediated microbicidal activity disease pathogenesis.Blood/liver tissues were collected from chronically HBV-infected...
The precise mechanism by which HBx protein of hepatitis B virus (HBV) impacts on hepato-carcinogenesis remain largely elusive despite strong evidences for its' involvement in the process. Here, we have investigated role expression a novel gene hELG1/ATAD5, is required genome maintenance and importance hepatocarcinogenesis. This study has first time showed that this was significantly higher human cancer such as HBV-associated hepatocellular carcinoma (HCC) different HCC cell lines compared to...
Background and aims Alcoholic liver disease (ALD) is the leading cause of cirrhosis related death worldwide. Excessive alcohol consumption resulting enhanced gut permeability which trigger sensitization inflammatory cells to bacterial endotoxins induces secretion cytokines, chemokines activation stellate cells, neutrophil infiltration hepatocyte injury followed by steatohepatitis, fibrosis cirrhosis. But all chronic alcoholics are not susceptible ALD. This study investigated causes...
Despite widespread distribution of hepatitis B virus (HBV)-genotype D, the clinical implications its ten subgenotypes (D1-D10) have not been well documented. Here, we investigated impact two major circulating HBV/D subgenotypes, D1 and D3 in Eastern India towards pathogenesis liver disease progression to hepatocellular carcinoma (HCC). HBV were determined using full-length genome sequences isolates from patients with chronic (CHB), cirrhosis (LC) HCC. Impact on viral lifecycle was assessed...
ABSTRACT Imbalance in lipid metabolism induces steatosis liver during Chronic hepatitis C (CHC). Contribution of microRNAs regulating homoeostasis and disease progression is well established using small RNA-transcriptome data. Owing to the complexity development diseases, existence functional importance yet undiscovered regulatory miRNAs pathogenesis was explored this study unmapped sequences transcriptome data HCV-HCC tissues following miRDeep2.pl pipeline. MicroRNA-c12 derived from first...
Abstract Differentiation of Crohn’s disease (CD) from intestinal tuberculosis (ITB) is a big challenge to gastroenterologists because their indistinguishable features and insensitive diagnostic tools. A non-invasive biomarker urgently required distinguish ITB/CD patients particularly in India, TB endemic region, where CD frequency increasing rapidly due urbanization. Among the three differentially expressed miRNAs obtained small RNA transcriptomic profiling ileocaecal/terminal ileal tissue...
<title>Abstract</title> Diverse mechanisms have been established to understand chemoresistance of hepatocellular carcinoma (HCC), but the contribution non-coding RNAs are not surveyed well. We aimed here explore lncRNA/miRNA axis in hepatitis C and B virus infected HCC investigate mechanism classify a potential therapeutic target for HCC. The small RNA transcriptome, qRT-PCR validation with liver tissues both HCV HBV patients revealed that...