A5086151876- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Pneumonia and Respiratory Infections
- Advanced Chemical Sensor Technologies
- Antibiotic Use and Resistance
- Neonatal and Maternal Infections
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Biosimilars and Bioanalytical Methods
- Antimicrobial Resistance in Staphylococcus
Erasmus University Rotterdam
2023-2025
Erasmus MC
2021-2025
Radboud University Nijmegen
2022
Radboud University Medical Center
2022
Leiden University Medical Center
2020-2021
Princess Margaret Cancer Centre
2020
University Health Network
2020
Abstract Objectives In pediatric patients, vancomycin plays a pivotal role in combating infections, necessitating precise therapeutic drug monitoring to ensure efficacy and safety. The adoption of model-informed precision dosing (MIPD) has demonstrated potential optimizing strategies based on the area under concentration-time curve (AUC24h). However, predictive performance population pharmacokinetic models using only trough concentrations estimate AUC24h not been evaluated. Methods...
Sepsis affects approximately 8% of pediatric intensive care unit (PICU) admissions in high-income countries. Ceftriaxone, a broad-spectrum beta-lactam antibiotic, is widely used for treating severe infections and bacterial meningitis children. Despite its frequent use, limited studies address the population pharmacokinetic (popPK) ceftriaxone pediatrics. External validation popPK models essential to confirm their suitability individualized dosing PICU patients, enabling selection model best...
Abstract Background There is a lack of evidence on oral amoxicillin pharmacokinetics and exposure in neonates with possible serious bacterial infection (pSBI). We aimed to describe disposition following intravenous administration provide dosing recommendations for preterm term treated pSBI. Methods In this pooled-population pharmacokinetic study, 3 datasets were combined nonlinear mixed-effects modeling. order evaluate administration, profiles different regimens simulated the developed...
175 Background: In its early stages, gastric cancer symptoms are frequently lacking, resulting in an often late and incurable diagnosis. A non-invasive, cheap, reliable screening method for could improve outcomes increase the number of surgically resectable cancers. Breath analysis has emerged as experimental non-invasive identification individuals suitable confirmatory, diagnostic upper gastrointestinal endoscopy. We aimed to evaluate accuracy applicability breath detection adults. Methods:...
Data published on the oral clavulanic acid pharmacokinetics in pediatric population is lacking. This research aimed to describe disposition following and intravenous administration provide insights into exposure based threshold concentrations for (pre-)term neonates infants. pooled pharmacokinetic study combined four datasets analysis NONMEM v7.4.3. Clavulanic was simulated using percentage of time above (%fT > C