Manoel Jorge Nobre

ORCID: 0000-0003-1837-9429
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About
Contact & Profiles
Research Areas
  • Neuroscience and Neuropharmacology Research
  • Neurotransmitter Receptor Influence on Behavior
  • Memory and Neural Mechanisms
  • Stress Responses and Cortisol
  • Neuroendocrine regulation and behavior
  • Olfactory and Sensory Function Studies
  • Neuropeptides and Animal Physiology
  • Biochemical Analysis and Sensing Techniques
  • Neural dynamics and brain function
  • Receptor Mechanisms and Signaling
  • Hearing, Cochlea, Tinnitus, Genetics
  • Attention Deficit Hyperactivity Disorder
  • Tryptophan and brain disorders
  • Nicotinic Acetylcholine Receptors Study
  • Substance Abuse Treatment and Outcomes
  • Alcohol Consumption and Health Effects
  • Health, Nursing, Elderly Care
  • Adipose Tissue and Metabolism
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Geography and Environmental Studies
  • Youth, Drugs, and Violence
  • Pharmacology and Obesity Treatment
  • Pain Mechanisms and Treatments
  • Death Anxiety and Social Exclusion
  • Treatment of Major Depression

Universidade de Ribeirão Preto
2008-2024

Centro Universitário de Franca
2012-2024

Universidade de São Paulo
2011-2024

Instituto de Neurociências e Comportamento
2007-2022

Consejo Superior de Investigaciones Científicas
2009-2010

Universidad Nacional de Córdoba
2006

Universidade do Estado do Rio de Janeiro
2004

Estácio (Brazil)
2004

Pontifical Catholic University of Rio de Janeiro
2004

Abstract: The fact that there is a complex and bidirectional communication between the immune nervous systems has been well demonstrated. Lipopolysaccharide (LPS), component of gram‐negative bacteria, widely used to systematically stimulate system generate profound physiological behavioural changes, also known as ‘sickness behaviour’ (e.g. anhedonia, lethargy, loss appetite, anxiety, sleepiness). Different ethological tools have analyse modifications induced by LPS; however, many researchers...

10.1111/j.1742-7843.2011.00824.x article EN Basic & Clinical Pharmacology & Toxicology 2011-11-07

Neural circuits in the dorsal periaqueductal grey matter (DPAG) play an important role integration of defensive behaviour. As considerable numbers μ and κ opioid receptors have been found this region, we studied effects morphine, [ 3 H]-[H- d -Phe-Cys-Tyr- -Trp-Orn-Thr-Pen-Thr-NH 2 ] (CTOP), a selective peptide antagonist for receptors, U-50488H, specific agonist nor-binaltorphimine (nor-BNI), long-lasting injected into DPAG rats submitted to corral method, conditioned place preference test....

10.1097/00008877-200011000-00005 article EN Behavioural Pharmacology 2000-11-01

The amygdala and ventral portion of the periaqueductal gray (vPAG) are crucial for expression contextual freezing behavior. However, it is still unclear whether also plays a role in defensive behaviors induced by electrical stimulation dorsal (dPAG). In present study, rats were implanted with electrodes into dPAG determination thresholds escape responses before after sham or electrolytic lesions amygdala. Animals then submitted to context fear conditioning procedure. Amygdala disrupted but...

10.1097/00001756-200410050-00028 article EN Neuroreport 2004-09-15

Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These include deficit sensorimotor gating and altered fear-like responses aversive Measures ultrasound vocalizations at 20–22 kHz when are exposed threatening conditions, such as novelty, have been taken a good measure fear. The fear-potentiated startle loud sounds prepulse inhibition tests considered reliable indicators anxiety attention impairments, respectively. Rats reared under conditions...

10.1159/000085820 article EN Neuropsychobiology 2005-01-01

Abstract Exposure to stress and prolonged exposure alcohol leads neuronal damages in several brain regions, being the medial prefrontal cortex (mPFC) one of most affected. These changes presumably reduce ability organism cope with these stimuli may underlie a series maladaptive behaviours among which include drug addiction withdrawal. Drug‐addicted individuals show pattern behavior similar patients lesions mPFC. This impairment decision‐making could be mechanisms responsible for transition...

10.1016/j.ijdevneu.2016.09.003 article EN International Journal of Developmental Neuroscience 2016-09-09
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