A5039684215- Computational Drug Discovery Methods
- Synthesis and biological activity
- vaccines and immunoinformatics approaches
- Protein Structure and Dynamics
- Melanoma and MAPK Pathways
- Growth Hormone and Insulin-like Growth Factors
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- RNA and protein synthesis mechanisms
- Alzheimer's disease research and treatments
- Monoclonal and Polyclonal Antibodies Research
- Cholinesterase and Neurodegenerative Diseases
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Leptospirosis research and findings
- Mosquito-borne diseases and control
- Phytochemicals and Antioxidant Activities
- Long-Term Effects of COVID-19
- Infective Endocarditis Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Ovarian function and disorders
- Parvovirus B19 Infection Studies
- Bacterial Infections and Vaccines
- Vitamin C and Antioxidants Research
- Phytochemicals and Medicinal Plants
National Institute of Nutrition
2016-2024
Indian Council of Medical Research
2017-2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Royal Society of Chemistry
2024
Sri Venkateswara Institute of Medical Sciences
2010-2015
Dr. Reddy's Laboratories (India)
2014
National Informatics Centre
2013
Institute of Bioinformatics
2011
Millet varieties were analyzed for nutritional, antinutritional, mineral and phenolic profiles. Inhibition potential of acids enzyme inhibition activity was estimated, alongside starch digestibility millet grains evaluated. Finger found to have high contents Ca, Fe, Zn, Mn Cu minerals. Proso pearl had protein content, whereas kodo foxtail contained more dietary fiber. Phytic acid comparatively higher in millet, oxalic total tannin content abundant finger millet. Total flavonoid bound...
2019 – Novel Coronavirus (2019-nCOV), enclosed large genome positive-sense RNA virus characterized by crown-like spikes that protrude from their surface, and have a distinctive replication strategy. The 2019-nCOV belongs to the Coronaviridae family, principally consists of virulent pathogens showing zoonotic property, has emerged as pandemic outbreak with high mortality morbidity rate around globe no therapeutic vaccine or drugs against 2019-nCoV are discovered till now. In this study, in...
Outbreak of Corona Virus Disease in late 2019 (COVID-19) has become a pandemic global Public health emergency. Since there is no approved anti-viral drug or vaccine declared for the disease and investigating existing drugs against COVID-19.AYUSH-64 an Ayurvedic formulation, developed patented by Central Council Research Sciences, India, been clinical use as anti-malarial, anti-inflammatory, anti-pyretic few decades. Thus, present study was undertaken to evaluate AYUSH-64 compounds available...
Leptospira interrogans, a Gram-negative bacterial pathogen is the main cause of human leptospirosis. Lipid A highly immunoreactive endotoxic center lipopolysaccharide (LPS) that anchors LPS into outer membrane Leptospira. Discovery compounds inhibiting lipid-A biosynthetic pathway would be promising for dissolving structural integrity leading to cell lysis and death LpxC, unique enzyme was identified as common drug target Herein, homology modeling, docking, molecular dynamics (MD)...
Owing to the instability of Epigallocatechin Gallate (EGCG), it may undergo auto-oxidation and form oxidised products or dimers. In present study, we aimed evaluate therapeutic effects, including antioxidation immunomodulatory action, Oxidised (O-EGCG) as compared native EGCG action these compounds on main protease (Mpro) docking against SARS-CoV-2. HCT-116 (Human Colon Cancer) cell lines were used estimate total antioxidant capacity lipid peroxidation levels pro-inflammatory markers (human...
The nutritional requirements are fulfilled by the vegetables through their daily consumption. Carotenoids vital components of which provide various health benefits apart from providing pigmentation to plant crops. During cooking processes, nutrients either degraded or increased depending upon type method employed. aim present study was evaluate effect different methods on carotenoids composition among organic and conventional vegetable samples in included six divided into three groups nature...
The aim of this study was to evaluate the probable protective effect α-lipoic acid against testicular toxicity in rats exposed carbimazole during embryonic period. Time-mated pregnant were from days 9-21. After completion gestation period, all allowed deliver pups and weaned. At postnatal day 100, F1 male assessed for selected reproductive endpoints. Gestational exposure decreased organ indices, daily sperm count, epididymal variables viz., viable sperm, motile HOS-tail coiled sperms....
Nitrogen-based heterocycles substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e, & 14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, HCT116 cancer cell lines.
AbstractInfective endocarditis (IE) has emerged as a public health problem due to changes in the etiologic spectrum and involvement of resistant bacterial strains with increased virulence. Developing potent vaccine is an important strategy tackle IE. Complete genome sequences eight selected pathogens IE paved way design common T-cell driven subunit vaccines. Comparative genomics subtractive genomic analysis were applied identify adinosine tri phosphate (ATP)-binding cassette (ABC)...
Therapeutic options for SARS-CoV-2 are limited merely to the symptoms or repurposed drugs and non-specific interventions promote human immune system. In present study, chromatographic in silico approaches were implemented identify bioactive compounds which might play pivotal role as inhibitor immunomodulator (TGF-β TNF-α). Tinospora cordifolia (Willd.) Miers was evaluated phenolic composition explored by high-performance thin layer chromatography (HPTLC). Furthermore, such cordifolioside,...
The purpose of our study is to understand the protective effects small molecule ligands for phosphorylated tau (p-tau) in Alzheimer's disease (AD) progression. Many reports show evidence that reported be an important contributor formation paired helical filaments (PHFs) and neurofibrillary tangles (NFTs) AD neurons. In AD, glycogen synthase kinase-3 beta (GSK3β), cyclin-dependent kinase-5 dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), are three kinases responsible...
Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase which has attracted significant attention during recent years in drug design studies. The deregulation of GSK-3β increased the loss hippocampal neurons by triggering apoptosis-mediating production neurofibrillary tangles and alleviates memory deficits Alzheimer's disease (AD). Given its role formation leading to AD, it been major therapeutic target for intervention hence was targeted present study. Twenty crystal structures...
Child abuse is a major public health concern with deep rooted squeal events on adult mental health. The childhood negligence and abusive connected invariably anxiety depressive disorders in life.The study focused to determine the prevalence of child abuse, connection depression course adulthood, evaluate effect Interprofessional approach knowledge awareness legal polices among young students professions Arunachal Pradesh, India.Four hundred sixty-one from Tomo Riba Institute Health Medical...
Monitoring infectious emerging diseases, especially the central nervous system infections, has become one of important priorities in health care system.Epidemiological, serological and bacteriological studies revealed that Streptococcus pneumonia, Neisseria meningitidis, Haemophilus influenzae type b Staphylococcus aureus are common pathogens bacterial meningitis.Therefore, identification drug targets these would be crucial to overcome resistance existing antibiotic therapy.In present study,...