A5106671818- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Nerve injury and regeneration
- Reconstructive Surgery and Microvascular Techniques
- Bone Tissue Engineering Materials
- Reconstructive Facial Surgery Techniques
- Protein Hydrolysis and Bioactive Peptides
- Bone Metabolism and Diseases
- Wound Healing and Treatments
- Bone and Dental Protein Studies
- Magnesium Alloys: Properties and Applications
- Facial Nerve Paralysis Treatment and Research
- Nerve Injury and Rehabilitation
- TGF-β signaling in diseases
- Bone and Joint Diseases
- Periodontal Regeneration and Treatments
- Hip and Femur Fractures
- Heterotopic Ossification and Related Conditions
- Graphene and Nanomaterials Applications
- Biomarkers in Disease Mechanisms
- Bone fractures and treatments
- Parathyroid Disorders and Treatments
Jinan University
2023
Shanghai Jiao Tong University
2018-2022
Shanghai Sixth People's Hospital
2018-2022
Soochow University
2013-2017
Abstract Silk fibroin (SF)‐based nerve conduits have been widely used to bridge peripheral defects. Our previous study showed that regeneration in a SF‐blended poly (l‐lactide‐co‐ɛ‐caprolactone) [P(LLA‐CL)] conduit is better than P(LLA‐CL) conduit. However, the involved mechanisms remain unclarified. Because angiogenesis within plays an important role regeneration, vascularization of SF/P(LLA‐CL) and was compared both vitro vivo . In present study, we observed nanofibers significantly...
Achieving a high number of inter-pore channels and nanofibrous structure similar to that the extracellular matrix remains challenge in preparation Bombyx mori silk fibroin (BSF) scaffolds for tissue engineering. In this study, Antheraea pernyi (ASF) micro/nano fibers with an average diameter 324 nm were fabricated by electrospinning from 8 wt % ASF solution hexafluoroisopropanol. The electrospun cut into short (~0.5 mm) then dispersed BSF solution. Next, prepared lyophilization. Scanning...
Abstract Magnesium (Mg) based alloy has been used as a biodegradable implant for fracture repair with considerable efficacy, and it proved that magnesium ion (Mg 2+ ), one of the degradation products, could stimulate osteogenesis. Here, we investigated osteogenesis property both in vitro vivo , to identify cellular molecular mechanisms mediate these effects. Results showed exerts dose‐dependent increase proliferation MC3T3 MG63 cells, expression osteopontin (OPN), promising biomarker...
Abstract The feasible fabrication of nerve guidance conduits (NGCs) with good biological performance is important for translation in clinics. In this study, poly( d , l ‐lactide‐ co ‐caprolactone) (PLCL) films loaded various amounts (wt; 5%, 15%, 25%) methylcobalamin (MeCbl) are prepared, and further rolled sutured to obtain MeCbl‐loaded NGCs. MeCbl can be released a sustainable manner up 21 days. proliferation elongation Schwann cells, the Neuro2a cells enhanced on these films. NGCs...
Background: Single-cell RNA sequencing (scRNA-seq) enables specific analysis of cell populations at single-cell resolution; however, there is still a lack single-cell-level studies to characterize the dynamic and complex interactions between osteoporotic vertebral compression fractures (OVCFs) Kümmell’s disease (KD) in osteoimmune microenvironment. In this study, we used scRNA-seq investigate microenvironment cellular composition OVCFs KD. Methods: ScRNA-seq was perform fractured bone...
The degradation rate of tissue engineering scaffolds should match the regeneration new tissues. Controlling behavior silk fibroin is an important subject for silk‐based scaffolds. In this study, Antheraea pernyi was successfully modified with succinic anhydride and then characterized by zeta potential, ninhydrin method, FTIR. vitro , three‐dimensional prepared were incubated in collagenase IA solution 18 days to evaluate impact acylation on behavior. results demonstrated that more rapid than...
Reconstruction of digital loss with soft tissue defects remains a tough challenge. Although combined flap toe and dorsal foot skin provides good option for "like-for-like" hand reconstruction, the disappointed donor site morbidity prevents it from popularity. In this study, we presented experiences superficial peroneal neurocutaneous (SPNC) closure after transfer.Superficial flaps were used to cover in 9 patients. The harvested feet including 3 cases wrap-around flap, 4 2nd 2 3rd flap. size,...
The posterior aspect of the leg is an ideal donor site for flap surgery. In this study, anatomy was investigated lateral sural cutaneous nerve (LSCN) and its accompanying artery, superficial artery (SLSA), a neurocutaneous designed.Five fresh adult cadaver legs perfused with red latex were dissected to observe course relationship between LSCN SLSA. outer diameter SLSA at origin measured. Then designed used repair soft tissue defects in six patients.The anatomic results showed that gave rise...
Objective To report clinical application of free chimeric vascularized fibular graft combined with sural flap for reconstruction composite extremity defects after open fracture. Methods From June 2010 to July 2014, grafts and flaps were used treat 4 patients at Department Orthopaedics, The Sixth People’s Hospital. They 3 men one woman, aged from 39 61 years(average, 48.5 years). There 2 cases soft tissue on the forearm complicated radial defect, case ulnar shaft leg tibial defect....