A5044003560- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Anesthesia and Neurotoxicity Research
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Advanced Drug Delivery Systems
University of Maryland, College Park
2020-2023
University of Pittsburgh
2017
Abstract Antigen-specific tolerance is a key goal of experimental immunotherapies for autoimmune disease and allograft rejection. This outcome could selectively inhibit detrimental inflammatory immune responses without compromising functional protective immunity. A major challenge facing antigen-specific ineffective control over signal targeting integration, limiting efficacy causing systemic non-specific suppression. Here we use intra-lymph node injection diffusion-limited degradable...
ConspectusImmunotherapies harness an individual's immune system to battle diseases such as cancer and autoimmunity. During cancer, the often fails detect destroy cancerous cells, whereas during autoimmune disease, mistakenly attacks self-tissue. Immunotherapies can help guide more effective responses in these settings, evidenced by recent advances with monoclonal antibodies adoptive cell therapies. However, despite transformative gains of immunotherapies for patients, many therapies are not...
Macrophage polarization during the host response is now a well-accepted predictor of outcomes following material implantation. Immunosenescence, dysregulation macrophage function, and delayed resolution immune responses in aged individuals have all been demonstrated, suggesting that to materials should differ from those younger individuals. However, few studies examining effects aging upon performed. The present work sought elucidate impacts polypropylene mesh implanted into 8-week-old...
Local signal integration in lymph nodes (LNs) controls the potency and selectivity of immune responses. Here, intra-LN depots were used to direct communication within treated LNs, causing programmable divergent systemic immunotherapy outcomes.
Autoimmune diseases are broadly characterized as a failure in immune tolerance. In multiple sclerosis (MS), autoreactive cells attack the protective myelin sheath lining neurons central nervous system. Therapeutic strategies that selectively and durably restore tolerance without broad immunosuppression urgently needed for MS. Our lab has developed assemblies of constructs built entirely from antigen (MOG
Abstract Autoimmune diseases such as Multiple sclerosis (MS) and diabetes affect more than 50 million people worldwide. We have previously demonstrated that intra-lymph node injection of polymer microparticles (MPs) loaded with myelin antigen (MOG) a tolerogenic immune cue (rapamycin) protect mice from experimental autoimmune encephalomyelitis (EAE), preclinical mouse model MS. However, an important aspect for safe translation new therapeutics is ensuring well-defined stable drug products...
Abstract Multiple sclerosis (MS) is an inflammatory disorder that occurs when autoreactive lymphocytes mistakenly attack myelin, resulting in motor deficits and cognitive deterioration. Current drugs are non-curative require life-long treatment make compliance challenging, existing therapeutics can leave patients vulnerable to opportunistic infections. An experimental approach overcome these hurdles drive long-lasting, antigen-specific regulatory T cells (Tregs) dampen responses...