A5061799532- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Pancreatic function and diabetes
- Liver Disease and Transplantation
Universidad de La Laguna
2019-2024
The serum- and glucocorticoid-induced kinase 1 (SGK1) is a transcriptional target of steroid hormones including glucocorticoids or aldosterone in addition to other stimuli such as glucose. SGK1 activated via phosphoinositide 3-kinase, placing it downstream insulin signaling. participates the upregulation kidney Na+ reabsorption by has been linked obesity-related hypertension humans. We hypothesized that systemic increase activity may trigger multiplicity mechanisms leading simultaneous...
Serum and glucocorticoid-regulated kinase 1 (SGK1) stimulates aldosterone-dependent renal Na+ reabsorption modulates blood pressure. In addition, genetic ablation or pharmacological inhibition of SGK1 limits the development kidney inflammation fibrosis in response to excess mineralocorticoid signaling. this work, we tested hypothesis that a systemic increase activity would potentiate mineralocorticoid/salt-induced hypertension injury. To end, used transgenic mouse model with increased...
Abstract Disclosure: A. Vastola-Mascolo: None. G. Hernández: D. Alvarez de la Rosa: The serum and glucocorticoid-induced kinase 1 (SGK1) is a Ser/Thr with key roles in fluid electrolyte homeostasis, blood pressure regulation energy metabolism. Its expression controlled by steroid hormones such as glucocorticoids, mineralocorticoids estrogen, addition to other stimuli glucose. SGK1 activation mainly depends on the PI3 pathway, implicating it insulin signaling. Previous work from our...
Liver cirrhosis is associated to circulatory abnormalities leading hypovolemia and stimulation of the renin-angiotensin-aldosterone system (RAAS). Advanced stages disease cause renal failure, impairing K+ Na+ homeostasis. It has been proposed that distal colon undergoes functional remodeling during in particular by aldosterone-driven increased excretion. In this study, we compared transcriptional response aldosterone target genes rat under two models circulating (one with concomitant RAAS...
ABSTRACT The serum and glucocorticoid-induced kinase 1 (SGK1) stimulates aldosterone-dependent renal Na + reabsorption modulates blood pressure. In addition, genetic ablation or pharmacological inhibition of SGK1 limits the development kidney inflammation fibrosis in response to excess mineralocorticoid signalling. this work we tested hypothesis that a systemic increase activity would potentiate mineralocorticoid/salt-induced hypertension injury. To end, used transgenic mouse model with...