A5065065612- Tuberculosis Research and Epidemiology
- Infection Control in Healthcare
- Infection Control and Ventilation
- Mycobacterium research and diagnosis
- Climate Change and Health Impacts
- Immune cells in cancer
- Bacteriophages and microbial interactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- HIV Research and Treatment
- Cancer therapeutics and mechanisms
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Nuclear reactor physics and engineering
- Fault Detection and Control Systems
- Scientific Measurement and Uncertainty Evaluation
- Disaster Response and Management
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
Rutgers, The State University of New Jersey
2016-2022
Rutgers New Jersey Medical School
2016-2022
Rutgers Health
2018-2020
The length and complexity of tuberculosis (TB) therapy, as well the propensity Mycobacterium to develop drug resistance, are major barriers global TB control efforts. M. is known have ability enter into a drug-tolerant state, which may explain many these impediments treatment. We identified mechanism genetically encoded but rapidly reversible tolerance in caused by transient frameshift mutations homopolymeric tract (HT) 7 cytosines (7C) glpK gene. Inactivating associated with 7C HT produce...
IFN-ε is a unique type I IFN that not induced by pattern recognition response elements. constitutively expressed in mucosal tissues, including the female genital mucosa. Although direct antiviral activity of was thought to be weak compared with IFN-α, controls Chlamydia muridarum and herpes simplex virus 2 mice, possibly through modulation immune response. We show here induces an state human macrophages blocks HIV-1 replication. had little or no protective effect activated CD4+ T cells...
Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that success depends on features hidden within a small minority the overall infecting Mycobacterium population. We developed multitranswell robotic system perform numerous parallel cultures genetically barcoded M. exposed steady-state concentrations rifampicin uncover these difficult-to-eliminate populations. found tolerance emerged repeatedly from at least...
Epigenetic modulators, including histone methylases, demethylases, and deacetylases, have been implicated previously in the regulation of classical alternative macrophage activation pathways. In this study, we show that acetyl transferase (HAT) Kat6B (MYST4) is strongly suppressed (>80%) macrophages by lipopolysaccharide (LPS) (M1 activation), while Kat6A, its partner MOZ/MORF complex, reciprocally upregulated. This pattern expression not altered LPS together with adenosine receptor...
Summary Background The COVID-19 pandemic has caused a severe shortage of personal protective equipment (PPE), especially N95 respirators. Efficient, effective and economically feasible methods for large-scale PPE decontamination are urgently needed. Aims (1) to develop protocols effectively decontaminating using vaporized hydrogen peroxide (VHP); (2) novel approaches that decrease set up take down time while also increasing capacity (3) test efficiency respirators heavily contaminated by...
SUMMARY Background COVID-19 has stretched the ability of many institutions to supply needed personal protective equipment, especially N95 respirators. decontamination and reuse programs provide one potential solution this problem. Unfortunately, a comprehensive evaluation effects on integrity various models using quantitative fit test (QTFT) approach is lacking. Aims 1) To investigate up eight rounds vaporized H 2 O (VHP) respirators currently in use hospital setting. 2) examine if worn by...
ABSTRACT Rapid emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is one the most significant healthcare challenges our time. The cause multifactorial, with long course anti-tubercular therapy required to treat (TB) constituting a major contributing factor. Introduction pyrazinamide (PZA) resulted shortening TB treatment from twelve six months and consequently played critical role curbing that developed over therapy. Nevertheless, because PZA prodrug activated by nonessential...
Abstract The length and complexity of tuberculosis (TB) therapy, as well the propensity Mycobacterium to develop drug resistance, are major barriers global TB control efforts. M. is known have ability enter into a drug-tolerant state, which may explain many these impediments treatment. We identified novel mechanism genetically encoded but rapidly reversible drug-tolerance in caused by transient frameshift mutations homopolymeric tract (HT) seven cytosines (7C) glpK gene. Inactivating...
Abstract Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease suggesting that success depends on features hidden within a small minority the overall infecting Mycobacterium (Mtb) population. We developed multi-transwell robotic system perform numerous parallel cultures genetically barcoded Mtb exposed steady-state concentrations rifampicin uncover these difficult eliminate populations. found tolerance repeatedly emerged...