A5021094006- Enzyme function and inhibition
- Synthesis and Catalytic Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Polyamine Metabolism and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Electrochemical sensors and biosensors
- Biochemical and Molecular Research
- thermodynamics and calorimetric analyses
- Chemical Reactions and Mechanisms
- Single-cell and spatial transcriptomics
- Pharmacogenetics and Drug Metabolism
- Innovative Microfluidic and Catalytic Techniques Innovation
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- CAR-T cell therapy research
- Enzyme Structure and Function
Vilnius University
2021-2025
Czech Academy of Sciences, Institute of Biotechnology
2024
Biological systems are inherently complex and heterogeneous. Deciphering this complexity increasingly relies on high-throughput analytical methods tools that efficiently probe the cellular phenotype genotype. While recent advancements have enabled various single-cell -omics assays, their broader applications limited by challenge of conducting multi-step biochemical assays while retaining biological analytes. Extending our previous work ( 1 ) here we present a versatile technology based...
We designed novel pre-drug compounds that transform into an active form covalently modifies particular His residue in the site, a difficult task to achieve, and applied carbonic anhydrase (CAIX), transmembrane protein, highly overexpressed hypoxic solid tumors, important for cancer cell survival proliferation because it acidifies tumor microenvironment helping invasion metastases processes. The have several functionalities: (1) primary sulfonamide group recognizing anhydrases (CA), (2)...
ABSTRACT We designed novel pre-drug compounds that transform into an active form covalently modifies particular His residue in the site, a difficult task to achieve, and applied carbonic anhydrase (CAIX), transmembrane protein, highly overexpressed hypoxic solid tumors, important for cancer cell survival proliferation because it acidifies tumor microenvironment helping invasion metastases processes. The have several functionalities: 1) primary sulfonamide group recognizing anhydrases (CA),...
We designed novel pre-drug compounds that transform into an active form covalently modifies particular His residue in the site, a difficult task to achieve, and applied carbonic anhydrase (CAIX), transmembrane protein, highly overexpressed hypoxic solid tumors, important for cancer cell survival proliferation because it acidifies tumor microenvironment helping invasion metastases processes. The have several functionalities: 1) primary sulfonamide group recognizing anhydrases (CA), 2)...
We designed novel pre-drug compounds that transform into an active form covalently modifies particular His residue in the site, a difficult task to achieve, and applied carbonic anhydrase (CAIX), transmembrane protein, highly overexpressed hypoxic solid tumors, important for cancer cell survival proliferation because it acidifies tumor microenvironment helping invasion metastases processes. The have several functionalities: (1) primary sulfonamide group recognizing anhydrases (CA), (2)...
We designed novel pre-drug compounds that transform into an active form covalently modifies particular His residue in the site, a difficult task to achieve, and applied carbonic anhydrase (CAIX), transmembrane protein, highly overexpressed hypoxic solid tumors, important for cancer cell survival proliferation because it acidifies tumor microenvironment helping invasion metastases processes. The have several functionalities: 1) primary sulfonamide group recognizing anhydrases (CA), 2)...