A5075512056- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Gut microbiota and health
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Cancer Research and Treatments
- IL-33, ST2, and ILC Pathways
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Fibroblast Growth Factor Research
- Nephrotoxicity and Medicinal Plants
- Cell Image Analysis Techniques
- Colorectal Cancer Screening and Detection
- CAR-T cell therapy research
King's College London
2024
University of Cambridge
2019-2021
NIHR Cambridge Biomedical Research Centre
2020
Genetic profiles of the bladder Depending on environment individual, human can be exposed to carcinogens as they are flushed through body. Lawson et al. and Li examined genetic composition laser-dissected microbiopsies from normal cancer cells collected urothelium, a specialized epithelium lining lower urinary tract (see Perspective by Rozen). These complementary studies identified mutational landscape urothelium various sequencing strategies high heterogeneity within between individuals...
Abstract Objectives Humanised mice have emerged as valuable models for pre‐clinical testing of the safety and efficacy immunotherapies. Given variety available, selection most appropriate humanised mouse model is critical in study design. Here, we aimed to develop a predicting cytokine release syndrome (CRS) while minimising graft‐ versus ‐host disease (GvHD). Methods To overcome donor‐induced variation, directly compared vitro vivo immune phenotype immunodeficient NSG reconstituted with...
Abstract Tissue fibrosis and extracellular matrix (ECM) stiffening have been shown to promote tumor cell proliferation, metastasis, chemoresistance in a range of cancers. Stiffness the ECM can lead changes cancer behavior, including enhanced activation mechano-sensitive signaling pathways, potential genomic damage, with implications for progression immune responses. Recent research suggests stiff may also induce release tumor-derived small vesicles (sEVs) that growth. Tumor-derived sEVs...