A5022312635- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant-Microbe Interactions and Immunity
- Nail Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
- Galectins and Cancer Biology
Rutgers, The State University of New Jersey
2022-2025
Rutgers Health
2025
Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foam cholesterol-laden derives from atherosclerosis research. We previously showed that, in tuberculosis, surprisingly accumulate triglycerides. Here, we utilized bacterial (Mycobacterium tuberculosis), fungal (Cryptococcus neoformans), and human papillary renal cell carcinoma (pRCC) models to address the need for a new explanation biogenesis. applied...
ABSTRACT Fungal pathogens are underappreciated causes of significant morbidity and mortality worldwide. In previous studies, we determined that a heat-killed, Cryptococcus neoformans fbp1-deficient strain (HK-fbp1) is potent vaccine candidate. We vaccination with HK-fbp1 confers protective immunity against lethal Cryptococcosis in an interferon γ (IFNγ)-dependent manner. this study, set out to uncover cellular sources relevant targets the effects IFNγ response vaccine. found early production...
Fungal pathogens often undergo morphological switches, including cell size changes, to adapt the host environment and cause disease. The pathogenic yeast Cryptococcus neoformans forms so-called 'titan cells' during infection. Titan cells are large, polyploid, display alterations in wall capsule, more resistant phagocytosis various types of stress. formation is regulated by cAMP/PKA signal pathway, which stimulated protein Gpa1. Here, we show that Gpa1 activated through phosphorylation a...
The ubiquitin–proteasome system (UPS) mediates intracellular proteins degradation that influences various cellular functions in eukaryotic cells. UPS is also involved the development and virulence of pathogenic fungi. F-box proteins, which are part SCF (Skp1-Cullin-F-box protein) ligase, a key component essential for recognition specific substrates. In this study, we identified 20 C. neoformans obtained deletion mutants 19 them. A comprehensive phenotypic analysis these revealed diverse...