A5068477615- Educational and Social Studies
- Tuberculosis Research and Epidemiology
- Italian Social Issues and Migration
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Global Educational Policies and Reforms
- Immune cells in cancer
- Dermatology and Skin Diseases
- Lipoproteins and Cardiovascular Health
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Global Education and Multiculturalism
- Diverse academic and cultural studies
- Italian Fascism and Post-war Society
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Histiocytic Disorders and Treatments
- Diabetes and associated disorders
- Tumors and Oncological Cases
- Genetic and rare skin diseases.
- Fungal Infections and Studies
- Immune responses and vaccinations
- Inflammasome and immune disorders
Rutgers, The State University of New Jersey
2016-2025
Rutgers Health
2023-2025
Boehringer Ingelheim (United States)
2025
University of Sassari
2024
Pontificia Universidad Católica de Valparaíso
2024
Rutgers New Jersey Medical School
2016-2022
University of Florence
2017-2021
Florence (Netherlands)
2020
University of Siena
2016
Ospedale Santa Maria alle Scotte
2013
Foam cells are lipid-laden macrophages that contribute to the inflammation and tissue damage associated with many chronic inflammatory disorders. Although foam cell biogenesis has been extensively studied in atherosclerosis, how these form during a infectious disease such as tuberculosis is unknown. Here we report that, unlike cholesterol-laden of tuberculous lung lesions accumulate triglycerides. Consequently, varies underlying disease. In vitro mechanistic studies showed triglyceride...
The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important for survival. In Gram-negative bacteria, integrity during stress is maintained by the multi-gene Psp response. Mycobacterium tuberculosis was thought to lack system since it encodes only pspA no other psp ortholog. Intriguingly, maps downstream from clgR, which a transcription factor regulated MprAB-σ(E) envelope-stress-signaling system. clgR inactivation...
Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foam cholesterol-laden derives from atherosclerosis research. We previously showed that, in tuberculosis, surprisingly accumulate triglycerides. Here, we utilized bacterial (Mycobacterium tuberculosis), fungal (Cryptococcus neoformans), and human papillary renal cell carcinoma (pRCC) models to address the need for a new explanation biogenesis. applied...
The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models. However, underlying molecular mechanisms are unknown. In this study, we used an vitro macrophage infection model investigate simvastatin's activity by systematically inhibiting each branch pathway evaluating effects branch-specific inhibitors on...
Much is to be learned about the interface between immune responses SARS-CoV-2 infection and vaccination. We monitored specific Spike Receptor-Binding-Domain (RBD) in convalescent individuals for eight months after diagnosis following Over time, neutralizing antibody responses, which are predominantly RBD specific, generally decreased, while RBD-specific memory B cells persisted. cell vaccination were more vigorous than those elicited by same subjects or infection-naïve comparators. Notably,...
<i>Background:</i> Histiocytoses represent a large, puzzling group of diseases which may involve the skin and other organs. At present, juvenile xanthogranuloma is disorder most often confused with Langerhans cell histiocytosis. A complex overlap exists between histiocytosis, lesions showing clinical and/or pathological features both disorders. <i>Observations:</i> We report 2 patients affected by histiocytosis who, during chemotherapy, presented cutaneous...
Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foam cholesterol-laden derives from atherosclerosis research. We previously showed that, in tuberculosis, surprisingly accumulate triglycerides. Here, we utilized bacterial ( Mycobacterium tuberculosis ), fungal Cryptococcus neoformans and human papillary renal cell carcinoma (pRCC) models to address the need for a new explanation biogenesis. applied...
Eruptive pseudoangiomatosis (EPA) is a rare, benign, spontaneously regressing childhood exanthem. The term was recently coined by Prose et al. 1 to describe dermatosis characterized the sudden onset of few several bright red angioma-like papules with different histopathology from true angiomas. We three patients typical lesions EPA but some peculiar features not previously described. discuss suspected viral aetiology EPA, and hypothesize multifactorial aetiopathogenesis.
The natural history of atopic dermatitis (AD) is variable. Generally the disappears during first years life, but it often followed by appearance allergic respiratory diseases (ARDs). Our aim was to establish risk factors for developing an ARD in children with AD. We up 4 78 (51 boys, 27 girls) mild (26%), moderate (48%), and severe (26%) AD (clinical score proposed Rajka Langeland). In all patients IgE serum levels were checked skin prick tests (SPTs) performed at examination. SPTs repeated...
Isolates of the human pathogen Mycobacterium tuberculosis recovered from clinical samples exhibit genetic heterogeneity. Such variation may result stressful environment encountered by inside macrophage, which is host cell tubercle bacilli parasitize. To study evolution M. genome during growth macrophages, we developed a model intracellular culture in bacteria were serially passaged macrophage-like THP-1 cells for about 80 bacterial generations. Genome sequencing single colonies isolated...
Multimodality evoked potentials and pattern electroretinograms (PERGs) were performed in seventeen patients with histologically defined mitochondrial myopathy (MM). Brainstem auditory showed abnormalities 47% somatosensory 76%. Visual outside the normal range 71%; PERGs exhibited a decreased amplitude or delayed P50 78%. These findings may be considered as an expression of impairment central nervous system MM, even if specific mechanism, 'structural' 'functional', needs further investigation.
Abstract Monitoring the burden and spread of infection with new coronavirus SARS-CoV-2, whether within small communities or in large geographical settings, is paramount importance for public health purposes. Serology, which detects host antibody response to infection, most appropriate tool this task, since virus-derived markers are reliably detected during acute phase infection. Here we show that our ELISA protocol, based on binding Receptor Binding Domain (RBD) S1 subunit viral Spike...
While the biomarkers of COVID-19 severity have been thoroughly investigated, key biological dynamics associated with resolution are still insufficiently understood.
Abstract Triglyceride rich macrophages (foam cells) are a hallmark of necrotic granulomas in tuberculosis, and multiple antimicrobial functions down-regulated these cells. In this study, we assessed the ability two different compounds to reduce triglyceride content intracellular burden Mycobacterium tuberculosis (Mtb)-infected macrophages: A-922500 (DGATi), an inhibitor diacylglycerol acyltransferase 1, enzyme involved synthesis; LY2584702 (p70S6Ki), p70 S6 kinase, serine/threonine kinase...
Resumen This paper offers a reflection on the necessity and importance of continuous training today for educators teachers who work in close contact with young people daily basis, by revision generic skills that make it possible to prevent extremist behaviour radicalisation among instead promote critical thinking, resilience, sense belonging social cohesion. At same time, contribution will report some significant results experience carried out through European Project DIVE IN "Preventing...