A5013333723- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
Hebei Medical University
2022-2024
Second Hospital of Hebei Medical University
2022-2024
Distal malignant biliary obstruction (DMBO) can result in obstructive jaundice. Endoscopic ultrasound- (EUS-) guided drainage (EUS-BD) has been an alternative for DMBO after failed ERCP.
Accumulating evidence has indicated the crucial role of microRNA-196 in mediating tumor progression, while its significance cholangiocarcinoma (CCA) remains unclear. In this study, we provided first that expression level miR-196-5p is elevated both CCA cell lines and clinic specimen. MiR-196-5p inhibition notably suppressed proliferation as well metastasis line HuCCT1. Furthermore, interaction between downstream molecule HAND1 was verified. Moreover, a series rescue assay verified β-catenin...