A5067932919- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Sports Performance and Training
- Total Knee Arthroplasty Outcomes
- Tracheal and airway disorders
- Proteoglycans and glycosaminoglycans research
- Silk-based biomaterials and applications
- Orthopedic Surgery and Rehabilitation
- Modular Robots and Swarm Intelligence
- Dysphagia Assessment and Management
- Winter Sports Injuries and Performance
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Dendrimers and Hyperbranched Polymers
- Advanced Sensor and Energy Harvesting Materials
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Surface Modification and Superhydrophobicity
- Airway Management and Intubation Techniques
- Dental materials and restorations
- Tendon Structure and Treatment
University of Delaware
2021-2024
Hospital for Special Surgery
2017
City College of New York
2017
Crosslinked, degradable, and cell-adhesive hydrogel microfibers were synthesized via interfacial polymerization employing tetrazine ligation, an exceptionally fast bioorthogonal reaction between strained trans-cyclooctene (TCO) s-tetrazine (Tz). A hydrophobic trisTCO crosslinker homo-difunctional poly(ethylene glycol) (PEG)-based macromers with the group conjugated to PEG a stable carbamate (PEG-bisTz1) bond or labile hydrazone (PEG-bisTz2) linkage synthesized. After laying ethyl acetate...
Toward the goal of establishing an engineered model vocal fold lamina propria (LP), mesenchymal stem cells (MSCs) are encapsulated in hyaluronic acid (HA)-based hydrogels employing tetrazine ligation with strained alkenes. To mimic matrix stiffening during LP maturation, diffusion-controlled interfacial bioorthogonal crosslinking is carried out on soft cellular construct using HA modified a ferocious dienophile, trans-cyclooctene (TCO). Cultures maintained MSC growth media for 14 days to...
Objective Many in vivo procedures to repair chondral defects use ultraviolet (UV)-photoinitiated situ polymerization within the cartilage matrix. Chemical species that absorb UV light might reduce effectiveness of these by acting as absorption barriers. This study evaluated whether any individual native biochemical components and synovial fluid interfered with common scaffolding photosensitizers. Materials UV-visible spectroscopy was performed on each major component solution, bovine fluid,...
There remains no routine treatment for congenital tracheal abnormalities affecting more than 1/3 of the length. Natural and artificial prostheses are plagued by mechanical failure inconsistent outcomes. Mimicking native tissue mechanics in an engineered replacement may improve functional patient We synthesized tubular constructs comprising photo-cross-linked methyl acrylate-co-methyl methacrylate, p(MA-co-MMA), with patterned r- z-axes order to achieve properties similar lamb tracheae. Hard...
A U-Net machine learning algorithm was adapted to automatically segment tendon collagen fibril cross-sections from serial block face scanning electron microscopy (SBF-SEM) and create three-dimensional (3D) renderings. We compared the performance of routine Otsu thresholding for a positional that has low density (rat tail tendon), an energy-storing high plantaris hypothesized have disorganized 3D ultrastructure (degenerated rat tendon). The area segmentation healthy had excellent accuracy...
Cartilage loses, recovers, and maintains its thickness, hydration, biomechanical functions by adjusting relative rates of load-induced fluid loss competitive recovery under varying joint-use conditions. While the mechanics implications have been studied extensively, those not. This study isolates, quantifies, compares cartilage from three known modes: (1) passive swelling – within a nominally unloaded contact; (2) free at an exposed surface; (3) tribological rehydration loaded contact area...