A5030215222- Gastrointestinal motility and disorders
- Pelvic floor disorders treatments
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Complementary and Alternative Medicine Studies
- CRISPR and Genetic Engineering
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Acupuncture Treatment Research Studies
- Gastrointestinal disorders and treatments
- Stress Responses and Cortisol
- Myofascial pain diagnosis and treatment
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Metastasis and carcinoma case studies
- Immunotherapy and Immune Responses
- Diverticular Disease and Complications
- Pathogenesis and Treatment of Hiccups
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
Universidad Andrés Bello
2024
Dartmouth–Hitchcock Medical Center
2014-2022
Lyell Immunopharma (United States)
2022
Omeros Corporation (United States)
2007
The role of ventral hippocampus (vHipp) astroglial gliotransmission in depression was studied using chronic restraint stress (CRS) and unpredictable mild (CUMS) rodent models. CRS increased Cx43 hemichannel activity extracellular glutamate levels the vHipp blocking hemichannel-dependent during prevented development buildup. Moreover, acute blockade hemichannels induced antidepressant effects rats previously subjected to or CUMS. This effect by coinjection D-serine. Furthermore, decreased...
Gastroparesis has a significant negative impact on patients' quality of life. Only one medication is approved for gastroparesis and it associated with risk side effects.To assess the willingness patients to take risks medications treat symptoms.We developed questionnaire risk-taking behaviour in identified as having documented (consistent symptoms, normal upper endoscopy, delayed gastric emptying). The survey assessed demographics, use, anxiety, depression impulsivity. A standard reference...
We describe the construction of a large-scale, orderly assembly mutant ES cells, generated with retroviral insertions and having mutational coverage in >90% mouse genes. also method for isolating cell clones mutations specific genes interest from this library. This approach, which combines saturating random mutagenesis targeted selection interest, was successfully applied to gene families G protein-coupled receptors (GPCRs) nuclear receptors. Mutant strains 60 different GPCRs were generated....
Signet-ring cell carcinoma is a rare adenocarcinoma, predominantly affecting the stomach and ovaries. Primary sites elsewhere are rarer. It recognized that there an increased cancer risk with diagnosis of Crohn's disease. We report patient disease who was diagnosed signet-ring in setting flare. Diagnosis made endoscopy. Treatment included laparoscopic-assisted right hemicolectomy ileostomy subsequent chemotherapy as outpatient.
ABSTRACT BACKGROUND AND AIMS Evaluation for dyssynergia is the most common reason that gastroenterologists refer patients anorectal manometry, because amenable to biofeedback by physical therapists. High-definition manometry (3D-HDAM) a promising technology evaluate physiology, but adoption remains limited its sheer complexity. We developed 3D-HDAM deep learning algorithm dyssynergia. METHODS Spatial-temporal data were extracted from consecutive studies performed between 2018-2020 at...
Introduction: The gastroesophageal reflux disease questionnaire (GerdQ) is a validated designed to identify patients presenting primary care office with (GERD). In study of tertiary center for wireless pH testing, the GerdQ was found have only modest sensitivity and specificity. goal this revise better diagnose group high percentage poor response proton pump inhibitors (PPI), also known as refractory GERD. Methods: Demographics, scores, functional GI symptoms were obtained from 115...
Introduction: Treating gastroparesis (GP) can be difficult as there is only one FDA approved medication for the treatment of GP and it associated with side effects in a substantial portion patients. The willingness patients to take risks medications treat unknown. Aims: To evaluate documented assess their used GP. Methods: A questionnaire was developed, revised after focus group patients, mailed previously identified having (those symptoms consistent GP, normal EGD, delayed 4 hour gastric...
INTRODUCTION: Total pancreatectomy with islet autotransplantation (TPIAT) performed to treat painful chronic pancreatitis requires a complex isolation process of the explanted pancreas. Islet has historically required specialized lab perform isolation. We report our experience novel technique intra-operative that does not require lab, thereby making simpler, more accessible and less costly. METHODS: retrospective, comparative effectiveness study 50 adult patients who underwent TPIAT at...
Total pancreatectomy with islet autotransplantation (TPIAT) requires a complex isolation process of the explanted pancreas. Islet has historically required specialized laboratory to perform isolation. We report our experience novel technique intraoperative that does not require laboratory, thereby making simpler, more accessible, and less costly.We performed retrospective, comparative effectiveness analysis 50 adult patients who underwent TPIAT from 2012 2020 (TPIAT remote [n = 20] versus...
<h3>Background</h3> Letetresgene autoleucel (lete-cel; GSK3377794) is a first-generation (1st gen) NY-ESO-1-specific T-cell receptor (TCR) therapy with demonstrated clinical activity in solid tumors.<sup>1-2</sup> Next-generation therapies are development the goal of further improving response rates and durability. Gen-R an <i>ex vivo</i> genetic reprogramming technology which T cells engineered to overexpress c-Jun, member activator protein 1 (AP-1) family transcription factors....
Abstract Total pancreatectomy with intraportal islet cell autotransplantation (TPIAT) allows for the islets to be isolated and subsequently re-infused prevent complications associated post-pancreatectomy diabetes in patients chronic or recurrent pancreatitis. TPIAT requires a complex isolation process of explanted pancreas, historically required specialized lab perform isolation. We report our unique 5-year experience comparing new technique intra-operative prior use off-site lab, thereby...