A5072875016- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Renal and related cancers
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Ectopic Pregnancy Diagnosis and Management
- Sexual Differentiation and Disorders
- Demographic Trends and Gender Preferences
- Congenital Anomalies and Fetal Surgery
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- Maternal and Perinatal Health Interventions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Smart Systems and Machine Learning
- CRISPR and Genetic Engineering
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
IVI Middle East Fertility Clinic
2014-2024
Middle East Technical University
2023
University Children's Hospital Tübingen
2023
Emirates Foundation
2021-2023
Koç University
2023
Taksim German Hospital
2008
Abstract STUDY QUESTION Does the insemination method impact euploidy outcome in couples with non-male factor infertility? SUMMARY ANSWER Conventional IVF can be applied cycles preimplantation genetic testing for aneuploidies (PGT-A), as both and ICSI generate equal numbers of euploid blastocysts. WHAT IS KNOWN ALREADY Ever since its introduction, popularity has increased tremendously, even infertility. The use conventional is a contraindication undergoing PGT to ensure monospermic...
How reliable are cleavage stage and trophectoderm (TE) biopsies compared to inner cell mass (ICM) biopsies?The reliability of TE biopsy ICM is almost perfect, but only substantial between biopsy.One the prevailing reasons for implantation failure presumed be chromosomal aneuploidy in human preimplantation embryos. Preimplantation genetic testing aneuploidies (PGT-A) has been introduced into assisted reproduction an effort increase pregnancy rates. Increasing evidence indicates that results...
Objective This study aimed to analyze the morphokinetic behaviour between conventional IVF and ICSI, in cycles with preimplantation genetic testing for aneuploidies (PGT-A). Materials A randomized controlled trial (NCT03708991) was conducted a private fertility center. Thirty couples non-male factor infertility were recruited November 2018 April 2019. total of 568 sibling cumulus oocyte complexes randomly inseminated ICSI cultured an Embryoscope time-lapse system. The IVF/ICSI oocytes...
Consanguineous marriage is defined as between first or second-degree cousins, with high prevalence in many cultures and societies. Descendants from consanguineous unions have an increased risk for genetic diseases. Additionally, couples, chromosomal disjunction during embryogenesis could also be affected, increasing the of errors. Nowadays, genomic testing allows to identify new syndromes variants related copy-number variations (CNV), including whole chromosome, segmental micro-segmental...
Abstract STUDY QUESTION Which patients might benefit from insemination of delayed-matured oocytes? SUMMARY ANSWER Delayed-matured oocytes had a ≥50% contribution to the available cohort biopsied blastocysts in with advanced maternal age, low maturation, and/or fertilization rates. WHAT IS KNOWN ALREADY Retrieved immature that progress MII stage vitro could increase number embryos during ICSI cycles. However, these are associated lower rates and compromised embryo quality. Data on ploidy...
One of the most important limitations genetic testing in preimplantation embryos is embryonic mosaicism, especially when performed on D3 with only a single blastomere evaluated. Previous publications, using Array-Comparative Genomic Hybridization (a-CGH) to compare day 3 (D3) biopsies versus trophectoderm for analysis aneuploid embryos, showed similar high concordance rates per embryo diagnosis and biopsies. Next generation sequencing (NGS) was introduced lately as new technique aneuploidies...
Can modelling the longitudinal morphokinetic pattern of euploid embryos during time-lapse monitoring (TLM) be helpful for selecting with highest live birth potential?
Context The widespread distribution of the Vitamin D (VitD) receptor in reproductive tissues suggests an important role for VitD human reproduction. assessment patient´s is based on 25-hydroxyvitamin (25(OH)D) metabolite measurement. However, most circulating 25(OH)D bound to either VitD-binding protein (VDBP) (88%) or albumin (12%) and less than 1% circulates free. Objective To determine a possible correlation between levels serum (S) follicular fluid (FF) blastocyst ploidy status patients...
ABSTRACT Although numerous studies have examined whether endometrial thickness (ET) independently affects the live birth rate (LBR) after an embryo transfer, contradictory conclusions resulted in unclear answer. It has been hypothesized that a thin endometrium decreases implantation rates possibly due to elevated oxygen concentration from spiral arteries; however, this mechanism not unequivocally demonstrated. This retrospective analysis aimed investigate ET LBR frozen transfer cycle. All...
Summary Embryos of optimal development reach blastocyst stage 116 ± 2 h after insemination. Usable D7 blastocysts represent nearly 5% embryos in IVF with acceptable pregnancy and live birth rates, however data are still limited. Therefore, this study aimed to analyze the ongoing rate (OPR) single euploid frozen embryo transfer (FET) cycles. An observational was performed including 1527 FET cycles biopsied on D5 ( N = 855), D6 636) 36). Blastocysts were classified as good (AA/AB/BA), fair...