A5102946660- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Neuroinflammation and Neurodegeneration Mechanisms
- Psychosomatic Disorders and Their Treatments
- Healthcare professionals’ stress and burnout
- Malaria Research and Control
- Cardiovascular Health and Disease Prevention
- Neurosurgical Procedures and Complications
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 Impact on Reproduction
- Neuroscience and Neuropharmacology Research
- Natural Compounds in Disease Treatment
- Advanced Drug Delivery Systems
- Coccidia and coccidiosis research
- Nutrition and Health in Aging
- Healthcare Systems and Public Health
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Adenosine and Purinergic Signaling
- Phytochemical compounds biological activities
Chengdu Fifth People's Hospital
2023-2024
Affiliated Hospital of Southwest Medical University
2017-2023
University of Macau
2018-2022
Science and Technology Department of Sichuan Province
2020-2021
Shanghai Clinical Research Center
2021
First Affiliated Hospital of Sichuan Medical University
2015
Southwest Medical University
2015
Beijing Institute of Neurosurgery
2013-2014
Capital Medical University
2013-2014
Capital University
2014
Ischemic stroke is characterized by the presence of both brain ischemic and reperfusion-induced injuries in brain, leading to neuronal dysfunction death.Artemisinin, an FDA-approved antimalarial drug, has been reported have neuroprotective properties.However, effect artemisinin on not known.In present study, we investigated using oxygen-glucose deprivation/reperfusion (OGD/RP) cellular model a mouse middle cerebral artery occlusion (MCAO) animal examined underlying mechanisms.The obtained...
Ischemic stroke is one of the leading causes death and disability among adults. Despite economic burden disease, available treatment options are still very limited. With exception anti-thrombolytics hypothermia, current therapies fail to reduce neuronal injury, neurological deficits mortality rates, suggesting that development novel more effective against ischemic urgent. In present study, we found artemether, which has been used in clinic as an anti-malarial drug, was able improve deficits,...
Abstract Uveal melanoma (UM) is a highly invasive intraocular malignancy with high mortality. Presently, there no FDA‐approved standard for the treatment of metastatic UM. Pristimerin natural quinine methide triterpenoid compound anti‐angiogenic, anti‐cancer and anti‐inflammatory activities. However, potential cytotoxic effect on UM was poorly investigated. In present study, we found migration invasion UM‐1 cells were inhibited by which also caused rapid increase ROS, decreased mitochondrial...
Circular RNA phosphorylase kinase regulatory subunit alpha 2 (circPHKA2; hsa_circ_0090002) has a significantly, specifically different expression in acute ischemic stroke (AIS) patients' blood. Here, we intended to investigate the role and mechanism of circPHKA2 oxygen-glucose deprivation- (OGD-) induced stoke model human brain microvascular endothelial cells (HBMEC).Expression circPHKA2, microRNA- (miR-) 574-5p, superoxide dismutase-2 (SOD2) was detected by quantitative PCR western...
Timing of treatment aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts different timing endovascular patients with hemorrhage. A database analyzed who were confirmed by CT, underwent between January 2005 2012,. The grouped into four according treatment: ultra-early cohort (within 24 hours onset which CT), early (between 72 intermediate 4 10 days CT) delayed (after 11 CT). Patient demographics,...
The cerebellar hemangioblastoma (CHB) has an abundant blood supply and deep anatomical location. Complete surgical resection is generally very difficult. This study investigated the safety effectiveness of preoperative embolization followed by CHB in a large cohort patients. A database 125 patients with Beijing Tiantan Hospital between July 2006 2012 was reviewed. Of those, 46 cases (experimental group) received embolization, 79 (control underwent surgery without embolization. Patient...
This study was designed to assess the effect of Enterprise stent on progressive occlusion wide-necked aneurysms and evaluate association between dubious factors occlusion, which is a consecutive, retrospective, single-center study. Data from 468 patients with 495 aneurysms, who had undergone stent-assisted coiling (SAC) were reviewed, clinical outcomes angiographic results analyzed. A 14-month follow-up achieved in 421 (90.0%), showing modified Rankin Scale (mRS) 0-1 364 (86.4%), mRS 2 17...
Backgrounds: Nursing is the key group to provide healthcare services, and it easy for nursing staff develop mental health problems. Aims: The study aimed evaluate prevalence of psychological symptoms in nurses working an intensive care unit (ICU) inter-relationship associations using network analysis. Methods: This a cross-sectional design study. Chinese version Symptom Check List-90 (SCL-90) was used measure status ICU nurses. structure characterised, indices ‘Expected influence’ were...
Purpose: This study was designed to quantify and characterize the variations of hemodynamic parameters for those large cerebral aneurysms with outflow vessel in plane main vortex. Materials Methods: A total 19 consecutive patients were constructed data digital subtraction angiography. Those vortex included. Blood flow hypothesized be laminar incompressible blood Newtonian fluid. Computational fluid dynamics ICEM Fluent software used simulate computational hemodynamics aneurysms. Results:...
Background and Objective: Giant cavernous carotid artery aneurysms (CCAAs) often produce a variety of neurological deficits, primarily those related to ophthalmoplegia/paresis headache. This study was designed evaluate the resolution symptoms after parent occlusion (PAO) treatment for giant CCAAs. Methods: We retrospectively reviewed series 17 consecutive CCAAs treated with PAO treatment. All patients were evaluated by balloon test (BOT) before Patients who could tolerate BOT PAO. The...
The prognosis of stroke patients is greatly threatened by malnutrition. However, there no model to predict the risk malnutrition in hospitalized patients. This study developed a predictive for identifying high-risk