A5091847792- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Prenatal Substance Exposure Effects
- Cardiac Arrest and Resuscitation
- Drug Transport and Resistance Mechanisms
- Congenital Anomalies and Fetal Surgery
- Pharmacogenetics and Drug Metabolism
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Neonatal Health and Biochemistry
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Urological Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Childhood Cancer Survivors' Quality of Life
- Folate and B Vitamins Research
- Biochemical Analysis and Sensing Techniques
- Maternal Mental Health During Pregnancy and Postpartum
- Emergency and Acute Care Studies
- Sodium Intake and Health
- Sepsis Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Artificial Intelligence in Healthcare and Education
- Infant Nutrition and Health
Medical College of Wisconsin
2011-2025
Children's Hospital of Wisconsin
1993-2024
Washington University in St. Louis
2023
University of Virginia
2023
Pediatrics and Genetics
2023
Froedtert Hospital
2021
Canadian Society for International Health
2005
University of Maryland, Baltimore
1996
Environmental exposure of parents or early in life may affect disease development adults. We found that hypertension and renal injury induced by a high-salt diet were substantially attenuated Dahl SS/JrHsdMcwiCrl (SS/Crl) rats had been maintained for many generations on the grain-based 5L2F compared with SS/JrHsdMcwi (SS/Mcw) casein-based AIN-76A (mean arterial pressure, 116±9 versus 154±25 mm Hg; urinary albumin excretion, 23±12 170±80 mg/d). RNAseq analysis outer medulla identified 129 82...
The prevalence of gastroschisis has been increasing for decades globally across all ages and races/ethnicities is one few birth defects with rising in both developing developed countries. However, there are some indications that rates the United States may be declining. We aim to investigate national 3 independent large-scale databases. hypothesize from 2016-2022, data will congruently reveal a decline States. This study retrospective cross-sectional database review datasets: 1 clinical...
The flavin-containing monooxygenases (FMOs) are important for xenobiotic metabolism. FMO3, the predominant FMO enzyme in human adult liver, exhibits significant interindividual variation that is poorly understood. This study was designed to identify common <i>FMO3</i> genetic variants and determine their potential contributing differences expression. single nucleotide polymorphism (SNP) discovery accomplished by resequencing DNA samples from Coriell Polymorphism Discovery Resource....
The flavin-containing monooxygenases (FMOs) are important for the disposition of a variety toxicants, therapeutics, and dietary components. Although FMO1 is dominant isoform in fetal liver adult kidney intestine despite up to 10-fold intersubject variation expression, paucity information available on <i>FMO1</i> genetic variability. To address this issue, 24 samples from Coriell DNA Polymorphism Discovery Resource Panel were sequenced revealing 10 common single nucleotide polymorphisms...
There are a considerable number of reports identifying and characterizing genetic variants within the <i>CYP2C9</i> coding region. Much less is known about polymorphic promoter sequences that also might contribute to interindividual differences in expression. To address this problem, approximately 10,000 base pairs upstream information were resequenced using 24 DNA samples from Coriell Polymorphism Discovery Resource. Thirty-one single-nucleotide polymorphisms (SNPs) identified; nine SNPs...
OBJECTIVES: The Modified Finnegan Neonatal Abstinence Scoring System (M-FNASS) and the newer Eat, Sleep, Console (ESC) model guide clinical management of neonatal opioid withdrawal syndrome (NOWS). In this study, we evaluate how M-FNASS ESC directly compare in inpatient practice. We hypothesized that scores would correlate with scores, whereas reduce health care use for infants NOWS. METHODS: retrospective cohort compared NOWS admitted to nursery settings. Epoch 1 was managed by using an...
A polymorphism for the phase I drug-metabolizing enzyme, flavin-containing monooxygenase isoform 2 (FMO2), encoding either truncated inactive protein, FMO2X472 (FMO2.2A), or full-length active FMO2Q472 (FMO2.1), is known and exhibits significant interethnic differences in allelic frequency. FMO2 major sole FMO expressed lung of most mammals, including nonhuman primates. To date, FMO2.1 has been found only African-American Hispanic populations, rendering individuals with this allele subject...
Introduction Neonatal hyperbilirubinemia (NH) is commonly diagnosed and managed by pediatricians in various clinical settings. The 2004 American Academy of Pediatrics (AAP) Clinical Practice Guideline on NH widely cited, but literature examining variation across pediatric specialties limited. This study aimed to assess baseline knowledge practice habits regarding among providers immediately prior the release 2022 guideline. Methods A non-probability, convenience, self-selected sampling...
Objectives Previous work defined two flavin-containing monooxygenase 2 (FMO2) alleles. The major allele, FMO2*2 (g.23,238C>T), encodes truncated inactive protein (p.X472) whereas the minor FMO2*1, present in African- and Hispanic-American populations, active (p.Q472). Recently, four common (27 to 51% incidence) FMO2 single nucleotide polymorphisms (SNPs) were detected African-Americans (N=50); they encode following variants: p.71Ddup, p.V113fs, p.S195L p.N413 K. Our objectives to: (1)...
Therapeutic hypothermia is an effective neuroprotective intervention for infants with moderate or severe hypoxic-ischemic encephalopathy (HIE). With the introduction of new medical therapy comes a learning curve regards to its proper implementation and understanding eligibility guidelines. We hypothesized that variation in patient selection lack adherence established protocols contributed utilization drift away from original guidelines.A retrospective cohort study was conducted including who...
Abstract Purpose Post-hemorrhagic ventricular dilation (PHVD) leads to developmental delays in premature infants, yet the optimal timing for neurosurgical interventions is unknown. Neuroimaging modalities have emerged delineate injury and follow progression of PHVD. Fronto-temporal horn ratio (FTHR) used as a marker can be standardized tool direct intervention. Our study determined pre-operative FTHR measurement threshold predict short- long-term outcomes. Methods This retrospective cohort...
Objective Antenatal breast milk expression (ABE) offers a host of benefits, including reduced formula consumption, support for breastfeeding success, and increased maternal satisfaction. Despite these advantages, experience with ABE differs significantly, often leading to anxiety over perceived inadequate supply eventual cessation. This study comprehensively evaluates the knowledge, attitudes, real-world experiences individuals gestational or pregestational diabetes concerning ABE, focus on...