A5088500246- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Analysis
- MicroRNA in disease regulation
- Asymmetric Synthesis and Catalysis
- RNA and protein synthesis mechanisms
- Luminescence and Fluorescent Materials
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Click Chemistry and Applications
- Cyclopropane Reaction Mechanisms
- Virus-based gene therapy research
- Adenosine and Purinergic Signaling
- Carbon and Quantum Dots Applications
- Nanomaterials for catalytic reactions
- Biosensors and Analytical Detection
- Synthesis and Biological Activity
- Organometallic Complex Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- SARS-CoV-2 detection and testing
Jeonbuk National University
2018-2023
Jeonju University
2020-2021
National Tsing Hua University
2014
Academia Sinica
2014
Institute of Chemistry, Academia Sinica
2014
Indian Institute of Science Bangalore
2011-2012
An aerobic oxidative cross-dehydrogenative coupling reaction between sp3 C–H and sp2 bonds is developed by employing a vanadium catalyst (10 mol%) in an aqueous medium using molecular oxygen as the oxidant. This environmentally benign strategy exhibits larger substrate scope shows high regioselectivity.
An efficient aerobic reduction of olefins, internal as well terminal, is developed using guanidine an organocatalyst. A remarkable chemoselectivity in has been demonstrated the presence a variety functional groups and protective selective terminal olefin revealed.
We have developed <bold>dUrkTP</bold> that displays AIE and used for direct labeling in conjunction with enhanced RCA facilitated the simple inexpensive detection of <bold>miRNA 24-3P</bold> high sensitivity (limit detection: 3.58 fM) selectivity.
We have developed an unprecedented transition metal–free approach for the direct fluorescence turn-on labeling of natural oligonucleotides through selective N<sup>6</sup>-arylation adenosine moieties.
We report the synthesis of two deoxyuridine derivatives (<bold>dUCN2</bold>, <bold>dUPy</bold>) that function as molecular rotors and this probing system proved to be useful for sensing gene regulation arising from interactions between G-quadruplex nucleolin.
In this study we developed a very simple and rapid miRNA 21 detection system using novel quinolinium diethylamino salicylaldehyde (QnDESA) probe for sensing the 22AG hybrid G-quadruplex with single-step rolling circle amplification (RCA) reaction. We synthesized circular DNA padlock template containing sequence complementary to G-quadruplex, used SplintR ligase ensure perfect hybridization 21, applied phi-29 polymerase tandem of sequence, then probed product QnDESA. This combination...
In this paper, we report a stepwise RNA-primed RNA polymerization method for the site-specific incorporation of multiple fluorescent moieties into RNA, mediated by an polymerase. A screen several polymerases revealed that T7 polymerase was only one functioned in polymerization. first fluorescence labeling step, rUthioTP residue incorporated directly using polymerase; second step performed post-labeling strategy: introducing rUamiTP polymerase, and then reacting with ylidenemalononitrile...
Abstract This type of etherification shows a high selectivity in favour the branched phenyl ethers.
Abstract An efficient procedure is elaborated for the chemoselective aerobic reduction of different alkenes, dienes and alkynes with hydrazine in presence guanidinium nitrate as a catalyst.