A5078359835- SARS-CoV-2 detection and testing
- Simulation-Based Education in Healthcare
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Innovations in Medical Education
- Sepsis Diagnosis and Treatment
- Dental Research and COVID-19
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Surgical Simulation and Training
- Reconstructive Surgery and Microvascular Techniques
- Congenital Anomalies and Fetal Surgery
- Healthcare Systems and Technology
- Geriatric Care and Nursing Homes
- Anesthesia and Neurotoxicity Research
- Health Literacy and Information Accessibility
- Homelessness and Social Issues
- Gallbladder and Bile Duct Disorders
- Wound Healing and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Family and Patient Care in Intensive Care Units
- Disaster Response and Management
- Dermatological and COVID-19 studies
Massachusetts General Hospital
2025
Johns Hopkins University
2020-2024
Johns Hopkins Children's Center
2021-2024
Johns Hopkins Medicine
2020-2023
University of North Carolina at Chapel Hill
2020
Abstract Background Outpatient coronavirus disease 2019 (COVID-19) has been insufficiently characterized. To determine the progression of and determinants hospitalization, we conducted a prospective cohort study. Methods adults with positive reverse transcription polymerase chain reaction results for severe acute respiratory syndrome 2 (SARS-CoV-2) were recruited by phone between April 21 July 23, 2020, after receiving outpatient or emergency department testing within large health network in...
Parkinson's disease (PD) is a progressive degenerative nervous system disorder and the second most common neurodegenerative in elderly population. The originates from loss of dopamine-producing neurons substantia nigra brain, resulting unregulated activity basal ganglia. Αlpha-synuclein (α-syn) protein found to aggregate region patients with PD, forming Lewy Body inclusions; its aggregation may contribute neuronal cell death PD. This work hypothesizes about synergistic relationship between...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic control will require widespread access to accurate diagnostics. Salivary sampling circumvents swab supply chain bottlenecks, is amenable self-collection, and less likely create an aerosol during collection compared with the nasopharyngeal swab. Methods We real-time reverse-transcription polymerase reaction Abbott m2000 results from matched salivary oral fluid (gingival crevicular collected in Oracol...
Abstract Background Sustained molecular detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the upper tract (URT) mild to moderate disease 2019 (COVID-19) is common. We sought identify host and immune determinants prolonged SARS-CoV-2 detection. Methods Ninety-five symptomatic outpatients self-collected midturbinate nasal, oropharyngeal (OP), gingival crevicular fluid (oral fluid) samples at home a research clinic median 6 times over 1–3 months. Samples were...
Abstract In a large cohort of ambulatory confirmed COVID-19 patients with multiple self-collected sample time points, we compared 202 matched nasal-oropharyngeal swabs and oral salivary fluid pairs by RT-PCR. Nasal-oropharyngeal were more sensitive than this type (oral crevicular fluid) suggesting that not all saliva types have equivalent sensitivity. However, samples Vero E6-TMPRSS2 cell culture positive (e.g., infectious virus) also RT-PCR may find the most likely to transmit disease others.
Abstract In an outpatient cohort in Maryland, clustering of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity within households was high, with 76% 74 reporting at least 1 other symptomatic person and 66% another who tested SARS-CoV-2 positive. among household members associated larger size bedroom sharing.
Globally, pediatric hospitals have implemented Pediatric Early Warning Scores (PEWS) to standardize escalation of care and improve detection clinical deterioration in patients. This study aims utilize qualitative methodology understand barriers facilitators PEWS implementation at Philippine Children's Medical Center (PCMC), a tertiary hospital Manila, Philippines.Semi-structured interviews querying current processes for monitoring, Intensive Care Unit (PICU) transfer, clinician attitudes...
Introduction: Children in resource-limited settings are disproportionately affected by common childhood illnesses, resulting high rates of mortality. A major barrier to improving child health such regions is limited pediatric-specific training, particularly the care children with critical illness. While global rotations for trainees from North America and Europe have become commonplace, residency fellowship programs struggle ensure that these mutually beneficial do not place an undue burden...
Gardner, Sarah; Ramos, Lorelie; Reuland, Carolyn; Evangelista, Paula Pilar; Shilkofski, Nicole Author Information
Sustained molecular detection of SARS-CoV-2 RNA in the upper respiratory tract (URT) mild to moderate COVID-19 is common. We sought identify host and immune determinants prolonged detection. Ninety-five outpatients self-collected mid-turbinate nasal, oropharyngeal (OP), gingival crevicular fluid (oral fluid) samples at home a research clinic median 6 times over 1-3 months. Samples were tested for viral RNA, virus culture, other human coronavirus antibodies, associations estimated using Cox...
Cystic biliary atresia is an uncommon form of that often misdiagnosed as a choledochal cyst. Here we present case neonate who presented with obstructive jaundice and antenatally-detected abdominal cyst was found to have cystic atresia. The patient underwent successful Kasai procedure for establishment flow. His initial post-operative course complicated by three episodes cholangitis requiring hospital admission. He now two years out from portoenterostomy normal bilirubin levels.
Abstract Background Shock causes significant morbidity and mortality in children living resource-limited settings. Simulation has been successfully used as an educational tool for medical professionals internationally. We sought to improve comfort knowledge regarding shock recognition fluid management by implementing a pediatric curriculum using simulation assessment trainees Manila, Philippines. Methods assessed focused on patients with malnutrition prospective cohort study, written test...
Introduction: Improving neurodevelopmental (ND) outcomes for children with congenital heart disease has become a priority. Known clinical and surgical risk factors do not fully capture differences in ND outcomes. The objective of this study was to determine if plasma metabolites at the time neonatal cardiac surgery were association 1 year. Methods: A secondary analysis trial 110 neonates undergoing performed. Plasma samples obtained pre-op, immediately post-op 12 hours post op had LC/MS/MS...