A5080794115- Ocular Oncology and Treatments
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- MRI in cancer diagnosis
- Cancer-related Molecular Pathways
- Ocular Disorders and Treatments
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Bone and Joint Diseases
- Neuroblastoma Research and Treatments
- Glaucoma and retinal disorders
- Parathyroid Disorders and Treatments
- Heterotopic Ossification and Related Conditions
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Bone health and treatments
- Corneal Surgery and Treatments
- Reconstructive Facial Surgery Techniques
- Neurofibromatosis and Schwannoma Cases
- Ear Surgery and Otitis Media
- Advanced MRI Techniques and Applications
- Hedgehog Signaling Pathway Studies
Amsterdam University Medical Centers
2018-2025
Dutch Cancer Society
2023-2025
Cancer Center Amsterdam
2018-2025
Vrije Universiteit Amsterdam
2011-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2012-2024
Amsterdam Neuroscience
2015-2024
University Medical Center Utrecht
2023-2024
Utrecht University
2024
Azienda Ospedaliera Universitaria Senese
2023
University of Siena
2015-2018
Background In the first (prevalent) supplemental MRI screening round of Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial, a considerable number breast cancers were found at cost an increased false-positive rate (FPR). incident rounds, lower cancer detection (CDR) is expected due to smaller pool prevalent cancers, reduced FPR, availability prior examinations. Purpose To investigate performance indicators second (incidence round) DENSE trial. Materials Methods The trial...
Retinoblastoma is the most common intraocular tumor in children. The diagnosis usually established by ophthalmologist on basis of fundoscopy and US. Together with US, high-resolution MRI has emerged as an important imaging modality for pretreatment assessment, i.e. diagnostic confirmation, detection local extent, associated developmental malformation brain intracranial primitive neuroectodermal (trilateral retinoblastoma). Minimum requirements evaluation retinoblastoma or mimicking lesions...
To assess diagnostic accuracy of preoperatively performed magnetic resonance (MR) imaging for detection tumor extent in a large patient population with histopathologically proved retinoblastoma.Local ethics committee approval and informed consent were not required retrospective review patients' images records. Fifty-eight eyes 28 girls (mean age, 21 months; range, 2-59 months) boys 24 2-76 retinoblastoma retrospectively reviewed by one radiologist on unenhanced T1-weighted, dual-echo...
<h3>BACKGROUND AND PURPOSE:</h3> DWI is typically performed with EPI sequences in single-center studies. The purpose of this study was to determine the reproducibility ADC values head and neck region healthy subjects. In addition, different tissues assessed identify most suitable reference tissue. <h3>MATERIALS METHODS:</h3> We prospectively studied 7 subjects, TSE sequences, on 5 MR imaging systems at 3 time points 2 institutions. maps (with b-values 6 b-values) were compared. Mean for...
Abstract Objectives Head and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by variety of quantitative features extracted from diagnostic images, termed radiomics. The aim this study was to develop validate MRI-based radiomic prognostic models in oral oropharyngeal cancer. Materials Methods Native T1-weighted images four independent, retrospective (2005–2013), patient cohorts ( n = 102, 76, 89, 56) were used delineate primary...
Human papillomavirus- (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) differs biologically and clinically from HPV-negative OPSCC has a better prognosis. This study aims to analyze the value of magnetic resonance imaging (MRI)-based radiomics in predicting HPV status develop prognostic model including MRI-based radiomics.Manual delineation 249 primary OPSCCs (91 HPV-positive 159 HPV-negative) on pretreatment native T1-weighted MRIs was performed used extract 498 radiomic...
Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN amplification (RB1 (+/+) MYCN(A) ). There are controversies concerning the existence of molecular subtypes within RB1(-/-) retinoblastoma. To test whether these exist, we performed profiling.Genome-wide mRNA expression profiling was on 76 primary human retinoblastomas. Expression complemented by genome-wide DNA and clinical, histopathological, ex vivo drug sensitivity data.RNA identified major variability between While...
Abstract Objectives To assess (I) correlations between diffusion-weighted (DWI), intravoxel incoherent motion (IVIM), dynamic contrast-enhanced (DCE) MRI, and 18 F-FDG-PET/CT imaging parameters capturing tumor characteristics (II) their predictive value of locoregional recurrence-free survival (LRFS) overall (OS) in patients with head neck squamous cell carcinoma (HNSCC) treated (chemo)radiotherapy. Methods Between 2014 2018, histopathologically proven HNSCC, planned for curative (chemo)...
. At present, the prognostic prediction in advanced oral cavity squamous cell carcinoma (OCSCC) is based on tumor-node-metastasis (TNM) staging system, and most used imaging modality these patients magnetic resonance image (MRI). With aim to improve prediction, we developed an MRI-based radiomic signature as a marker for overall survival (OS) OCSCC compared it with published gene expression signatures prognosis of OS head neck cancer patients, replicated herein our dataset.For each patient,...
<h3>BACKGROUND AND PURPOSE:</h3> Retinoblastoma may exhibit variable hyperintensities on DWI, resulting in different values the ADC maps, depending their histology and cellularity. However, EP-based DWI has susceptibility artifacts image distortions, which make of orbit a challenging technique. The aim this study was to investigate feasibility single-shot turbo spin-echo (HASTE) evaluation children with retinoblastoma assess value maps differentiating viable necrotic tumor tissue....
Trilateral retinoblastoma (TRb) is a rare disease associating intraocular with intracranial primitive neuroectodermal tumor. Treatment difficult and prognosis poor. This multicenter study evaluates clinical findings MR imaging characteristics of associated tumors in Rb patients. Clinical data 17 patients (16 TRb 1 quadrilateral patients) included time intervals between diagnosis presence baseline brain-imaging (BBI). Two reviewers reviewed all images individually one reviewer per center...
Radiomics is aimed at image-based tumor phenotyping, enabling application within clinical-decision-support-systems to improve diagnostic accuracy and allow for personalized treatment. The purpose was identify predictive 18-fluor-fluoro-2-deoxyglucose (18F-FDG) positron-emission tomography (PET) radiomic features predict recurrence, distant metastasis, overall survival in patients with head neck squamous cell carcinoma treated chemoradiotherapy.Between 2012 2018, 103 retrospectively (training...
Retinoblastoma mimickers, or pseudoretinoblastoma, are conditions that show similarities with the pediatric cancer retinoblastoma. However, false-positive retinoblastoma diagnosis can cause mistreatment, while false-negative life-threatening treatment delay. The purpose of this study is to identify MR imaging features best differentiate between and most common pseudoretinoblastoma diagnoses: Coats’ disease persistent fetal vasculature (PFV). Here, six expert radiologists performed...
In retinoblastoma, accurate segmentation of ocular structure and tumor tissue is important when working towards personalized treatment. This retrospective study serves to evaluate the performance multi-view convolutional neural networks (MV-CNNs) for automated eye on MRI in retinoblastoma patients. Forty 20 healthy-eyes from 30 patients were included a train/test (N = 29 retinoblastoma-, 17 healthy-eyes) independent validation 11 3 set. Imaging was done using 3.0 T Fast Employing...