A5102920210- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Child and Adolescent Psychosocial and Emotional Development
- Advanced MRI Techniques and Applications
- Bipolar Disorder and Treatment
- Mental Health Treatment and Access
- Maternal Mental Health During Pregnancy and Postpartum
- Obsessive-Compulsive Spectrum Disorders
- Mental Health and Psychiatry
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neuroscience and Music Perception
- Resilience and Mental Health
- Substance Abuse Treatment and Outcomes
- Asthma and respiratory diseases
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Digital Mental Health Interventions
- COVID-19 and Mental Health
- Psychosomatic Disorders and Their Treatments
University of Sussex
2021-2022
University of Minnesota
2021
Westat (United States)
2021
King's College London
2009-2020
De Montfort University
2019
University of Glasgow
2013
NHS Greater Glasgow and Clyde
2013
University of London
2012
Kings Health Partners
2010-2012
King's College - North Carolina
2010-2011
The integrity of brain white matter connections is central to a patient's ability respond pharmacological interventions. This study tested this hypothesis using specific measure integrity, and examining its relationship treatment response prospective design in patients within their first episode psychosis. Diffusion tensor imaging data were acquired 63 with psychosis 52 healthy control subjects (baseline). Response was assessed after 12 weeks classified as responders or non-responders...
At present, no reliable predictors exist to distinguish future responders from nonresponders treatment during the first episode of psychosis. Among potential neuroimaging response, gyrification represents an important marker integrity normal cortical development that may characterize, already at illness onset, a subgroup patients with particularly poor outcome.To determine whether first-episode psychosis who do not respond 12 weeks antipsychotic have significant defects onset.Case-control...
Background The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it also possible that psychological stress plays a role, inducing chronic inflammatory process may predispose development abnormalities. We investigated association between childhood maltreatment and biomarkers subjects first-episode healthy controls. Method Body mass index (BMI), weight waist circumference were measured 95 97 Inflammatory markers...
Abstract Antipsychotic drugs act on the dopaminergic system (first‐generation antipsychotics, FGA), but some also directly affect serotonergic function (second‐generation SGA) in brain. Short and long‐term effects of these brain physiology remain poorly understood. Moreover, it remains unclear whether any physiological effect may be different for FGAs SGAs. Immediate (+3.30 h) single‐dose FGA (haloperidol, 3 mg) a SGA (aripiprazole, 10 resting cerebral blood flow (rCBF) were explored same 20...
Health care workers experience high stress. Accessible, affordable, and effective approaches to reducing stress are lacking. In-person mindfulness-based interventions can reduce health worker but not widely available or accessible busy workers. Unguided, digital, self-help (MBSH) show promise be flexibly engaged with. However, their effectiveness in has yet been explored a definitive trial.
Background Cognitive impairment, particularly in memory and executive function, is a core feature of psychosis. Moreover, psychosis characterized by more prominent history stress exposure, dysregulation the hypothalamic–pituitary–adrenal (HPA) axis. In turn, exposure abnormal levels main HPA axis hormone cortisol are associated with cognitive impairments variety clinical experimental samples; however, this association has never been examined first-episode (FEP). Method study, 30 FEP patients...
Background: The "jumping to conclusions" (JTC) data-gathering bias is implicated in the development and maintenance of psychosis but has only recently been studied first episode (FEP). In this study, we set out establish relationship JTC FEP with delusions neuropsychological functioning. Methods: One hundred eight patients 101 age-matched controls completed assessments delusions, general intelligence (IQ), working memory (WM), (the probabilistic reasoning "beads" task). Results: Half...
Background: An association between social disadvantage and established psychosis is well documented in the literature, but there remains a lack of data on circumstances patients before they became ill. We investigated whether at, prior to, first contact with psychiatric services, associated psychosis. Method: collected information childhood adulthood from 278 cases presenting their episode to South London Maudsley National Health Service Foundation Trust 226 controls recruited local...
Connectomic approaches using diffusion tensor imaging have contributed to our understanding of brain changes in psychosis, and could provide further insights into the neural mechanisms underlying response antipsychotic treatment. We here studied network organization patients at their first episode evaluating whether connectome-based descriptions networks predict treatment, they change after Seventy-six with a psychosis 74 healthy controls were included. Thirty-three classified as responders...
Background The use of cannabis with higher Δ9-tetrahydrocannabinol content has been associated greater risk, and earlier onset, psychosis. However, the effect potency on brain morphology never explored. Here, we investigated whether pattern are changes in corpus callosum (CC) microstructural organization, patients first-episode psychosis (FEP) individuals without psychosis, users non-users. Method CC 56 FEP (37 users) 43 (22 was virtually dissected segmented using diffusion tensor imaging...
Converging evidence suggests that patients with first-episode psychosis who show a poor treatment response may have higher degree of neurodevelopmental abnormalities than good Responders. Characterizing the disturbances in relationship among brain regions (covariance) can provide more information on integrity searching for localized changes brain. Graph-based connectomic approach measure structural covariance thus providing maturational processes. We quantified cortical folding using graph...
Background Sexual dysfunction is common in psychotic disorder but it not clear whether intrinsic to the development of illness or secondary other factors. Aims To compare sexual function people at ultra-high risk (UHR) a disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers. Method was assessed UHR group ( n = 31), 37) matched control volunteers 56) using Function Questionnaire. Results There significant effect on P <0.001)....
This randomized within-subject, double blind study aimed to compare the effects of a single dose two different antipsychotics (haloperidol and aripiprazole) on cortisol, interleukin (IL)-6 hippocampal regional Cerebral Blood Flow (rCBF) in same 17 healthy male individuals. Subjects received haloperidol (3 mg), aripiprazole (10 mg) placebo, order three appointments. We measured salivary cortisol levels at multiple time points, IL-6 from plasma samples, resting cerebral blood flow (rCBF),...
Abstract Background: Why patients with psychosis use cannabis remains debated. The self-medication hypothesis has received some support but other evidence points towards an alleviation of dysphoria model. This study investigated the reasons for in first-episode (FEP) and whether strength their endorsement changed over time. Methods: FEP inpatients outpatients at South London Maudsley, Oxleas Sussex NHS Trusts UK, who used cannabis, rated motives baseline ( n = 69), 3 months 29) 12 36). A...
Current and early life stress (ELS) are associated with diurnal cortisol patterns, which themselves mental physical health. The pubertal recalibration hypothesis suggests that the social environment can impact dysregulated patterns for previously ELS-exposed youth as they transition through puberty. This study examined longitudinal change in awakening response (CAR) slope (DS) across puberty a function of ELS infancy, current stress, support (N = 290, 7-17 years). CAR DS were thrice annually...