A5016257117- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Zebrafish Biomedical Research Applications
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Protist diversity and phylogeny
- Moringa oleifera research and applications
- Barrier Structure and Function Studies
- Vector-Borne Animal Diseases
- Cardiovascular Effects of Exercise
- Neurogenetic and Muscular Disorders Research
- Renal and related cancers
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Circular RNAs in diseases
- Retinal Development and Disorders
- Drug-Induced Ocular Toxicity
- Wound Healing and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrospun Nanofibers in Biomedical Applications
Leitat Technological Center
2022
Instituto de Investigación Sanitaria La Fe
2013-2017
Centro de Investigacion Principe Felipe
2008-2017
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2009-2017
Consejo Superior de Investigaciones Científicas
2009
Defects in GABAergic function can cause epilepsy. In the last years, cell-based therapies have attempted to correct these defects with disparate success on animal models of Recently, we demonstrated that medial ganglionic eminence (MGE)-derived cells grafted into neonatal normal brain migrate and differentiate functional mature interneurons. These are able modulate local level GABA-mediated synaptic inhibition, which suggests their suitability for therapies. However, it is unclear whether...
Purpose.: To identify metabolic pathways and metabolites affected by optic nerve crush that can act as predictors of the disease or therapeutic targets. Methods.: The left adult rats was intraorbitally crushed retinas were dissected 24 hours 14 days after lesion (n = 10 per group). Metabolic profiling analysis carried out Metabolon, Inc. A total 195 unambiguously detected. Data normalized regulated identified comparing different conditions. Metabolite concentration changes analyzed using...
Human dermo-epidermal skin equivalents (DE) comprising in vitro expanded autologous keratinocytes and fibroblasts are a good option for massive burn treatment. However, the lengthy expansion time required to obtain sufficient surface cover an extensive together with challenging surgical procedure limits their clinical use. The integration of DE biodegradable scaffolds has been proposed effort enhance mechanical properties. Here, it is shown that poly(hydroxybutyrate) electrospun (PHB)...
Summary γ‐Aminobutyric acid (GABA) has an important role in the mechanism of epilepsy. Cell grafts from different sources have been performed to modulate local circuits or increase GABAergic inhibition animal models Among transplanted cell types, medial ganglionic eminence (MGE)–derived cells present best properties be used cell‐based therapy. In this work we review previous experiences with these cells. addition, new evidence showing their ability levels host brain mice alterations system,...
Recent reports have shown that bone marrow-derived cells (BMDCs) contribute to the formation of vasculature after stroke. However, mechanism by which mural are formed from BMDC remains elusive. Here, we provide direct evidence cell fusion process contributes pericytes We generated mouse marrow chimeras using a cre/lox system allows detection events X-gal staining. In these mice, detected X-gal-positive expressed vimentin and desmin, specific markers mature murine pericytes. Electron...
Many studies have reported the contribution of bone marrow-derived cells (BMDC) to CNS, raising possibility using them as a new source repair damaged brain tissue or restore neuronal function. This process has mainly been investigated in cerebellum, which degenerative microenvironment suggested be responsible for its modulation. The present study further analyzes BMDC different neural types other adult areas, under both physiological and neurodegenerative conditions, together with mechanisms...
Ataxias are locomotor disorders that can have an origin both neural and muscular, although impairments related. Unfortunately, ataxia has no cure, the current therapies aimed at motor re-education or muscular reinforcement. Nevertheless, cell therapy is becoming a promising approach to deal with incurable diseases, including neuromuscular ataxias. Here, we used model of ataxia, Purkinje Cell Degeneration (PCD) mutant mouse, study effect healthy (wild-type) bone marrow transplantation on...
Oxidative stress (OS) can induce cell apoptosis and thus plays an important role in aging. Antioxidant foods protect tissues from OS contribute to a healthier lifestyle. In this study, we described the used of medaka embryos (Oryzias latipes) study putative antioxidant capacity dietary cocoa extract vertebrates. A polyphenol-enriched regulated expression several genes implicated OS, thereby protecting fish induced OS. The activated superoxide dismutase enzyme activity adult tissues,...
Patients suffering from Usher syndrome (USH) exhibit sensorineural hearing loss, retinitis pigmentosa (RP) and, in some cases, vestibular dysfunction. USH is the most common genetic disorder affecting and vision included a group of hereditary pathologies associated with defects ciliary function known as ciliopathies. This clinically classified into three types: USH1, USH2 USH3. accounts for well over one-half all cases mutations USH2A gene are responsible majority but also atypical recessive...
Abstract Fetal liver (FL) hematopoietic progenitors have superior blood engraftment competence compared with adult bone marrow (BM), however less is known about FL in vivo vascular capacity. Here we show transplantation assays that cells possess enhanced endothelial potential marrow. We generated high-level chimeras using donor from mice transgenic for the stem cell leukaemia 3′ enhancer human placental alkaline phosphatase (SCL3′Enh-PLAP) reporter construct, active endothelium, and...
Tesis presentada para optar al grado de Doctor por la Universidad Valencia, Facultad Ciencias Biologicas-Departamento Biologia Celular y Parasitologia: Programa Neurociencias Basicas Aplicadas que ha sido realizada en las siguientes instituciones: - Hospital General Universitario Valencia; - Centro Investigacion Principe Felipe (CIPF) Salamanca; CABIMER Sevilla.