A5052589355- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- Social Sciences and Governance
- Receptor Mechanisms and Signaling
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Eicosanoids and Hypertension Pharmacology
- Acute Ischemic Stroke Management
- Hormonal Regulation and Hypertension
- Neurological Disease Mechanisms and Treatments
- Blood Pressure and Hypertension Studies
- Computational Drug Discovery Methods
- Cardiovascular Health and Disease Prevention
- Peroxisome Proliferator-Activated Receptors
- Electron Spin Resonance Studies
- Ginkgo biloba and Cashew Applications
- Motivation and Self-Concept in Sports
- Historical Geography and Geographical Thought
- Coenzyme Q10 studies and effects
- Quinazolinone synthesis and applications
- Problem Solving Skills Development
- Drug Transport and Resistance Mechanisms
- Spanish Literature and Culture Studies
- Sulfur Compounds in Biology
- Lysosomal Storage Disorders Research
Université de Lorraine
2012-2024
Cibles thérapeutiques, formulation et expertise préclinique du médicament
2011-2024
Amicus Therapeutics (United Kingdom)
2022
Université Laval
2002-2009
Weatherford College
2005
Boehringer Ingelheim (France)
2005
British Pharmacological Society
2005
Inserm
2005
University of Alberta
2002
Treatment of stroke, especially during the first hours or days, is still lacking. S-nitrosoglutathione (GSNO), a cerebroprotective agent with short life time, may help if administered early sustain delivery while avoiding intensive reduction in blood pressure. We developed situ forming implants (biocompatible biodegradable copolymer) and microparticles (same polymer solvent emulsified an external oily phase) GSNO to lengthen its effects allow cerebroprotection after single subcutaneous...
Antihypertensive treatment with angiotensin-converting enzyme inhibitors (ACEIs) reverses cerebral arteriolar remodeling, thus restoring dilatation and hence the lower limit of blood flow (CBF) autoregulation (LLCBF). The objective this study was to determine whether angiotensin II receptor AT1 blockers (ARBs) produce same effect.We examined effects an ARB [telmisartan (TEL), 1.93 +/- 0.04 mg/kg per day] or ACEI [ramipril (RAM), 1.00 0.02 on circulation in spontaneously hypertensive rats...
We examined the effects of an angiotensin-converting enzyme inhibitor (ACEI), captopril, on cerebral arterioles in young and old spontaneously hypertensive rats (SHR). Animals were anesthetized with sodium pentobarbitone (60 mg kg(-1) day(-1)). measured blood flow (CBF, arbitrary units) arteriolar internal diameter (ID, mum) prior to during stepwise hypotension (SH) 6- (WKY-6) 15-month-old (WKY-15) Wistar Kyoto age-matched SHR that untreated (SHR-6 SHR-15) or treated for 3 months captopril...
Antihypertensive treatment with standard clinical doses of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) reverses cerebral arteriolar remodeling, thus restoring dilatation and the lower limit blood flow (CBF) autoregulation (LL CBF AR). In humans, a combination two drugs does not produce greater protection against stroke than that obtained single-drug treatments increases risk side-effects. We hypothesized suboptimal ARB, telmisartan (TEL) ACEI,...
Angiotensin II (Ang II) induces constriction (AT(1)) and dilation (AT(2) receptors) of cerebral arterioles. High sodium intake changes in receptors expression loss AT(2)-mediated vasodilation extracerebral vessels. We investigated whether high salt modifies the response arterioles.Three-month-old male Wistar rats received drinking water supplemented or not with 1% NaCl. measured at day 4 30 plasma aldosterone concentration, AT (brain microvessels, western blot, RT-qPCR), internal diameter...
Angiotensin II (AngII) regulates cerebral circulation and binds with a similar affinity to AT
Background and Purpose Chronic hypertension decreases internal diameter of cerebral arteries arterioles. We recently showed that short-term treatment with the angiotensin II receptor blocker telmisartan restored baseline small arterioles in spontaneously hypertensive rats (SHR), via reversal structural remodeling inhibition vasoconstrictor response. As larger also participate regulation circulation, we evaluated whether similar affects middle SHR. Methods Baseline diameters pressurised from...
Background and objective: The prognosis of cardiac arrest victims strongly depends on the prompt provision Basic Life Support (BLS) maneuvers. Medical students should therefore be proficient in this area, but many lack essential BLS knowledge. goal prospective, closed web-based study was to determine whether a short intervention designed motivate first-year medical follow blended course could lead significant improvement knowledge following year. Materials Methods: A fully automated...
Melatonin deprival in young rats induces alterations cerebral arteriolar wall similar to those observed during aging: atrophy and a decrease distensibility. In this study, we examined the effects of melatonin treatment on structure distensibility lower limit blood flow autoregulation (LLCBF) old rats. We measured (arbitrary unit, laser Doppler, open skull preparation) prior stepwise hypotension (SH) adult (12/13 months) (24/25 IcoWI WAG/Rij male Old were untreated or treated for 3 months...
Chronic treatment with angiotensin receptor blockers is largely accepted for protecting cerebral circulation during hypertension, but beneficial effects of short-term treatments are questionable, as highlighted by the recent SCAST trial. We compared impact 10 days candesartan (as SCAST) versus telmisartan (previously described to reverse arteriolar remodeling, chronic treatment) on pial arterioles spontaneously hypertensive rats (SHR). explored whether PPAR-gamma agonist activity or AT1...
Angiotensin II (AngII) and NO regulate the cerebral circulation. AngII AT1 receptors exert ligand-dependent ligand-independent (myogenic tone [MT]) vasoconstriction of vessels. induces post-translational modifications proteins such as S-nitrosation (redox modification cysteine residues). In cultured cells, decreases AngII's affinity for receptor. The present work evaluated functional consequences on both AngII-dependent AngII-independent cerebrovascular responses.S-Nitrosation was induced in...
We examined cerebral arteriolar structure and autoregulation of blood flow (CBF) in control ( n = 8), sham-operated pinealectomized 10), plus melatonin-treated (0.51 ± 0.01 mg · kg −1 day drinking water, 9) young Wistar rats. The lower limit CBF (LLCBF) was determined by measurement (in arbitrary units, laser Doppler) during stepwise hypotensive hemorrhage; the internal diameter (ID; μm, cranial window) also measured. Measurements ID were repeated a second hypotension after smooth muscle...
Cet article décrit la méthodologie d'adaptation et de validation d'instruments mesure portant sur le stress capacité résolution problèmes sociaux. Nous présentons également quelques balises théoriques, d'autres modèles du sociaux ainsi que les résultats des analyses d'items deux instruments mesure. tentons répondre aux questions recherche suivantes: quelles sont caractéristiques psychométriques indicateurs chez stagiaire en enseignement? Quelles outre d'analyses factorielles. La ces a...
Background/Objectives: French community pharmacists have been given new missions on vaccination since 2019, with now the ability to administer and prescribe vaccines people aged 11 over.The main objective of study was assess perceptions attitudes pharmacy students in vaccination.Methods: We conducted a national survey using self-administered questionnaire targeting final-year from 24 faculties France, September 5th December 1st, 2023.Three themes were explored: general, initial training...
During the dispensing process of medical orders (MOs), community pharmacists (CPs) can manage drug-related problems (DRPs) by performing pharmacist interventions (PIs). There is little evidence that PI rate higher with MOs from hospitals (MOHs) than ambulatory (MOAs) settings, and their impact on patient pharmacy unknown. The primary objective this study was to compare MOH MOA rates. secondary describe PIs clinical organizational impacts workflow. A total 120 CPs participated in a...
<h3>Background</h3> Stroke is the second cause of premature mortality and sudden death in rheumatoid arthritis (RA) after myocardial infarction<sup>1</sup>. The mechanisms involved high risk stroke are currently unknown, but data from general population argue for a contribution cerebrovascular dysfunction. <h3>Objectives</h3> aim our study was to investigate function rat adjuvant-induced (AIA) model unravel involved, with special emphasis on pathways regulating nitric oxide (NO) vascular...