A5036654130- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Steroid Chemistry and Biochemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Chromatography
- Biofuel production and bioconversion
- Pharmacogenetics and Drug Metabolism
- Chemical Synthesis and Analysis
- Microbial metabolism and enzyme function
- Carbohydrate Chemistry and Synthesis
- Asymmetric Hydrogenation and Catalysis
- Enzyme Production and Characterization
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Biochemical Acid Research Studies
- Plant biochemistry and biosynthesis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Biochemical and biochemical processes
- Microbial Metabolites in Food Biotechnology
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Catalysis for Biomass Conversion
- Chemistry and Chemical Engineering
- Protein Hydrolysis and Bioactive Peptides
University of Milan
2016-2025
University of Messina
2023-2024
University of Padua
2022
IMT School for Advanced Studies Lucca
2022
Tampere University
2022
Universidade Federal do Paraná
2022
Mylan (Switzerland)
2016-2019
Ministerio de Defensa
2016-2019
Mylan (South Africa)
2016
Sapienza University of Rome
2011
The development of efficient syntheses for enantiomerically enriched alpha-hydroxy ketones is an important research focus in the pharmaceutical industry. For example, are found antidepressants, selective inhibitors amyloid-beta protein production (used treatment Alzheimer's), farnesyl transferase (Kurasoin A and B), antitumor antibiotics (Olivomycin Chromomycin A3). Moreover, particular value as fine chemicals because their utility building blocks larger molecules. They can also be used...
The continuous flow synthesis of a series amines was successfully achieved by exploiting the enhanced stability and broad substrate scope an immobilised transaminase from <italic>Halomonas elongata</italic> (HEWT).
To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate reliability enzyme-based methodologies directly applied production high value products.
Winning the primaries: Oxidation of primary and secondary alcohols, to their corresponding aldehydes or carboxylic acids ketones respectively, are among most important reactions in organic synthesis. In this Minireview we cover oxidation alcohols by biotransformation.
Abstract A straightforward one‐step biocatalyzed synthesis of different N ‐acyl amides in water was accomplished using the versatile and chemoselective acyltransferase from Mycobacterium smegmatis (MsAcT). Acetylation primary arylalkyl amines achieved with a range acetyl donors biphasic systems within 1 hour at room temperature. Vinyl acetate best donor which could be employed ‐acetylation large excellent yields (85–99%) after just 20 minutes. Other acyl (including formyl‐, propionyl‐,...
Endocrine disruptors (EDs) pose significant risks to human and environmental health, with potential implications for neurotoxicity. This study investigates the synergistic neurotoxic effects of perfluorooctane sulfonate (PFOS) glyphosate (GLY), two ubiquitous EDs, using SHSY5Y neuronal C6 astrocytic cell lines. While individual exposures PFOS at non-toxic concentrations did not induce changes, their combination resulted in a marked increase oxidative stress neuroinflammatory responses....
Soybean is one of the most important crops worldwide, being placed ninth on chart cultivated species. Its high level production correlates with a huge amount waste produced. These residues could be great interest due to presence high-value-added molecules, including some glycosides (i.e., daidzin, genistin, glycitin) widely studied for their potent antioxidant properties. Due low bioavailability and limited solubility in lipidic media, lipophilization strategies have recently gained momentum...
Contamination of wine by Dekkera/Brettanomyces bruxellensis is mostly due to the production off-flavours identified as vinyl- and especially ethyl-phenols, but these yeasts can also produce several other spoiling metabolites, such acetic acid biogenic amines. Little information available about correlation between growth, viability off-flavour amine production. In present work, five strains Dekkera isolated from were analysed over 3 months in wine-like environment for cell survival, carbon...
Abstract The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. first step heterogeneous biocatalyzed regio‐ stereoselective oxidation cheap prochiral 2‐methyl‐1,3‐propandiol, performed in using immobilized whole cells Acetobacter aceti MIM 2000/28, thus avoiding the use aggressive environmentally harmful chemical oxidants. isolation highly hydrophilic...
Abstract A new mild and efficient process for the aqueous preparation of aldehydes, which are employed as flavour fragrance components in food, beverage, cosmetics, well pharmaceuticals, was developed using a continuous‐flow approach based on an immobilised pure transaminase‐packed bed reactor. HEWT, ω‐transaminase from haloadapted bacterium Halomonas elongata, has been selected its excellent stability substrate scope. Sixteen different amines were rapidly (3–15 min) oxidised to...
A straightforward biocatalytic method for the enzymatic preparation of different flavor esters starting from primary alcohols (e.g., isoamyl, n-hexyl, geranyl, cinnamyl, 2-phenethyl, and benzyl alcohols) naturally available ethyl formate, acetate, propionate, butyrate) was developed. The biotransformations are catalyzed by an acyltransferase Mycobacterium smegmatis (MsAcT) proceeded with excellent yields (80–97%) short reaction times (30–120 min), even when high substrate concentrations (up...
With the aim of developing bioprocesses for waste valorization and a reduced water footprint, we optimized two-step fermentation process that employs oleaginous yeast Cutaneotrichosporon oleaginosus production oil from liquid cheese whey permeate. For first step, addition urea as cost-effective nitrogen source allowed an increase in biomass production. In second syrup candied fruit processing, another food supplied carbon feeding, triggered lipid accumulation. Consequently, lipids were...