LncRNA NEAT1 functions as an oncogene in multiple human cancers. However, its expression and role fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) remain unclear. Thus, we investigated the of synovial tissues FLSs RA, to determine development RA. Quantitative real-time polymerase chain reaction was used measure NEAT1. FLS proliferation evaluated using cell assays. Flow cytometry analyze cycle progression apoptosis FLSs. Binding between miR-410-3p demonstrated...

Accumulating evidence suggests that miR-483−3p is implicated in maintaining biological properties human cancers. However, its roles rheumatoid arthritis (RA) remain unknown. levels synovial tissue samples and fibroblast-like synoviocytes (FLSs) were determined using quantitative real-time PCR. The CCK-8 assay EdU staining performed to assess cell proliferation RA FLSs after transfection with mimics or inhibitor. Flow cytometry Annexin V-FITC PI was apoptosis cycle progression FLSs,...

This paper aims to investigate the function of structural maintenance chromosome 4 (SMC4) in progression hepatocellular carcinoma (HCC) under hypoxic condition. In this study, we found that suppression SMC4 could inhibit proliferation and migration HCC cells through inducing G1 phase arrest affecting process epithelial-mesenchymal transition (EMT) Moreover, demonstrated was transcriptionally regulated by hypoxia-inducible factor-1 (HIF-1) As SMC has been shown be a target gene miR-219,...

Abstract Background miR-431-5p is dysregulated in various cancers and plays an important function the development of cancer. However, its role fibroblast-like synoviocytes (FLSs) patients with rheumatoid arthritis (RA) remains to be understood. Methods Quantitative real-time polymerase chain reaction was used detect relative expression synovial tissues FLSs. Cell proliferation assays helped examine RA FLS proliferation. Flow cytometry performed determine apoptosis cell cycle progression We...

Biomaterial mediated bone regeneration is an attractive strategy for defect treatment. Organic/inorganic composites have been well established as effective graft. Here, the regenerative effect of made from tannic acid (TA) modified hydroxyapatite (HA) (THA) or TA & silver nanoparticles (Ag NPs) HA (Ag-THA) and polyurethane (PU) was evaluated on critical-sized calvarial defects in rats. The vivo study indicates that PU/THA PU/Ag-THA scaffolds exhibited acceptable biocompatibility induced...

A flexible and efficient resistive sheet boundary condition (RSBC)-based hybrid finite element-boundary integral-multilevel fast multipole algorithm (FE-BI-MLFMA) is presented for computing electromagnetic scattering from inhomogeneous objects with microwave-absorbing honeycomb structures. In the proposed algorithm, each nonmagnetic high lossy material coated unit cell wall of first approximated by multilayered RSBC as a zero-thickness to eliminate computational burden due extremely thin...

Citrate-based mussel-inspired magnesium whitlockite composite adhesives were developed to augment bone-to-tendon healing, by providing interface adhesion, promoting bony inward growth from the bone tunnel, and enhancing chondrogenesis osteogenesis of bone–tendon interface.

Schematic representation of the structure and functioning mechanism DD particles.

Microparticles (MPs) exhibit fast dissolution, characterized by a burst drug release pattern. In the present work, we prepared core-shell MPs of simvastatin (SIM) and zein with chitosan (CS) nano-hydroxyapatite (nHA) as carrier using coaxial electrospray deposition method. The morphology, formation in vitro osteogenic differentiation these were studied. synthetic have diameter about 1 μm they are composed non-toxic natural materials. They provide an effective way to enable long-term...

Tomato is a model system for studying fleshy fruit development. After fertilization, cell division and expansion in the pericarp are crucial development determine final size. TKN3 was found to be expressed tomato ovary wall/pericarp of zero two days post-anthesis fruits as KNOX I class member, but its function elusive. Here, we that mutations by CRISPR/Cas9 caused developmental defects, weight dramatically reduced tkn3cr mutant. Histological observation pericarps revealed mutation repressed...

A passive vibration isolator with broad frequency field (zero dynamic stiffness system) is designed in this paper, whose mathematics model built applying a method. Then the static and analysis of conducted ADAMS software. The zero system developed based on theoretic study simulation analysis. Moreover, experimental validation modal acquired. experiment shows that natural has dropped from 11.715 Hz to 2.5421 because importing negative mechanism. result better reduction effect between 3 100 Hz.

The layered structure graphitic carbon nitride (g-C3N4) makes it possible to form good interfacial contact with metal oxide nanoparticles. In this paper, we obtain the TiO2/g-C3N4 (TC) composite via ultra-sonication and apply as photoanode materials in dye-sensitized solar cells (DSSCs). TC photoanodes decrease energy barrier of electron transport improve injection efficiency photo-generated electrons. Moreover, g-C3N4 broadens absorption spectrum TiO2 based visible region enhances light...

We present in this letter an efficient numerical method for the analysis of electromagnetic scattering by inhomogeneous objects with arbitrarily oriented honeycomb radar absorbing structures. In method, each cellular structure is first homogenized as a diagonal anisotropic medium local coordinate system using new hybrid Hashin–Shtrikman and Mori–Tanaka formula. Then, Euler rotation matrix employed describing arbitrary orientation global transforming tensor into general 3 × tensor. Finally,...

This paper presents a type of NEMS (Nano-Electromechanical System) double Si3N4 resonant beams pressure sensor. The mathematical models are established in allusion to the and sensitive diaphragm. distribution state stress has been analyzed theoretically based on model diaphragm; from analysis result, position above diaphragm was optimized then dominance observed after adopted is illustrated. From optimized, illustrating advantages adoption beams. capability sensor generally using ANSYS...

A structure of TiN double resonant beams pressure sensor is presented, the measured through relation between frequency and pressure. In this paper, maths model sensitive structures established, analysis numeration from theory, simulation by ANSYS software, varied extension length optimization are educed optimal position beam on membrane confirmed. BACKGROUND

This paper takes the VHF band radio interference array antenna of Yunnan observatory site as an example. The influence different ground on radiation characteristics is simulated by HFSS (High Frequency Simulator Structure) electromagnetic simulation software, and after adding network below are simulated. Simultaneously, structure parameters single screen in 30-70 MHz frequency obtained. Without screen, gain dry grounds 3.06 dB 1.435 dB, moist 4.327 4.246 dB. After placing 4.869 4.971 4.286...

In this paper, we present a fast and accurate method for solving electromagnetic scattering from complex objects with honeycomb radar absorbing structures based on the hybrid finite element-boundary integral-multilevel multipole algorithm (FE-BI-MLFMA). method, extremely thin walls of dielectric are approximated by impedance boundary conditions (IBC) then reduced to zero-thickness resistive sheets, thus main computation burden computing field interaction structure is eliminated. Then, it...

We propose in this paper a novel hybrid numerical modeling method for computing electromagnetic scattering from inhomogeneous targets containing honeycomb structures. In the proposed approach, whole structure is divided into inner and outer two subregions. Each thin wall of unit cell subregion replaced by zero-thickness surface, with aid resistive sheet boundary condition (RSBC) to describe electric magnetic field discontinuities across surface. homogenized using Hashin–Shtrikman Mori–Tanaka...

A type of NEMS double Si <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> N xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> resonant beams pressure sensor is presented in this paper. The maths models are established allusion to the and sensitive diaphragm. Based on model beams, relation between frequency key dimensions analyzed. diaphragm, distribution state stress analyzed theoretically, through analysis result, position where placed...

As a two-dimensional (2D) nanostructure, reduced graphene oxide (rGO) has high specific surface area and excellent conductivity.In this paper, we obtain the TiO2/rGO (TG) composite via simple mechanical stirring mixtures of anatase TiO2 nanoparticles (GO) nanosheets followed by calcination process apply it as photoanode material in dye-sensitized solar cells (DSSCs).rGO TG can inhibit charge recombination increase short-circuit current density (Jsc) thus improve power conversion efficiency...