A5073167890- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Skin and Cellular Biology Research
- Hedgehog Signaling Pathway Studies
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Esophageal and GI Pathology
- Chemotherapy-related skin toxicity
- Cancer Diagnosis and Treatment
- Acne and Rosacea Treatments and Effects
- Cardiac tumors and thrombi
- Contact Dermatitis and Allergies
- Erythrocyte Function and Pathophysiology
- Skin Protection and Aging
- Intestinal Malrotation and Obstruction Disorders
- Congenital limb and hand anomalies
- Fibroblast Growth Factor Research
- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobin structure and function
- Pediatric Hepatobiliary Diseases and Treatments
- Dermatology and Skin Diseases
- Hair Growth and Disorders
- Insect and Pesticide Research
- Polyomavirus and related diseases
- Skin Diseases and Diabetes
Keio University
2019-2024
Keio University Hospital
2021-2024
RIKEN Center for Integrative Medical Sciences
2022-2023
Clinical Research Management
2022
Nerima General Hospital
2017
Immune checkpoint inhibitors (ICIs), such as pembrolizumab (PEM), are widely recognized for their antitumor efficacy, but they can also lead to various cutaneous adverse events (CAEs). While most CAEs be managed with topical corticosteroids, severe cases may necessitate halting immunotherapy. The incidence of is notably higher in combination therapies involving ICIs than monotherapies, emphasizing the need stringent, long-term management strategies. This includes potential modifications or...
A prenatal second-hit genetic change that occurs on the wild-type allele in an embryo with a congenital pathogenic variant results mosaicism of monoallelic and biallelic defect gene, which is called superimposed mosaicism. Superimposed Hailey-Hailey disease (HHD) has been demonstrated one familial case. Here, we report two unrelated HHD cases mosaicism: ATP2C1, followed by postzygotic copy-neutral loss heterozygosity. Uniquely, neither patient had family history at time presentation. In...
The epidermis, the keratinized stratified squamous epithelium surrounding body surface, offers a valuable framework to investigate how terrestrial animals overcome environmental stresses. However, mechanisms underlying epidermal barrier function remain nebulous. In this study, we examined genes highly expressed in human and mouse upper outer frontier that induces various barrier-related genes. Transcriptome analysis revealed messenger RNA level of hemoglobin α (HBA), an oxygen carrier...
Extramammary Paget disease (EMPD) is an intraepithelial adenocarcinoma that primarily affects the genital and axillary areas in older individuals. A limited number of paired patients with familial EMPD (i.e. parent-offspring, siblings) have been reported but genetics not yet adequately studied. We report, to best our knowledge, first cases involving three affected siblings. The tumour-only multigene panel testing using surgical specimens revealed a heterozygous c.2997A>C (p.Glu999Asp)...
An 81-year-old man who had been diagnosed as having situs inversus totalis and suffered from repeated episodes of sigmoid volvulus was admitted with a history right upper quadrant abdominal pain. Physical examination showed no evidence peritoneal irritation. A plain radiograph the abdomen markedly dilated colon an inverted U-shaped appearance. Abdominal CT totalis, free air, ascites, whorled appearance mesentery, bowel loops. Based on these findings, patient recurrence volvulus. Colonoscopy...