A5102996313- Tea Polyphenols and Effects
- Biochemical Analysis and Sensing Techniques
- Fatty Acid Research and Health
- Neonatal Respiratory Health Research
- Regulation of Appetite and Obesity
- Proteins in Food Systems
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Virtual Reality Applications and Impacts
- Chromatography in Natural Products
- Tryptophan and brain disorders
- Tannin, Tannase and Anticancer Activities
- Mind wandering and attention
- Phytase and its Applications
- Cancer, Hypoxia, and Metabolism
- Diet, Metabolism, and Disease
- Polyamine Metabolism and Applications
- Polysaccharides Composition and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Phytoestrogen effects and research
- Innovative Human-Technology Interaction
- Technology Use by Older Adults
University of Liverpool
2025
Texas Children's Hospital
2021-2024
Baylor College of Medicine
2019-2024
Third People's Hospital of Yunnan Province
2024
Children's Nutrition Research Center at Baylor College of Medicine
2018-2021
China Railway Group (China)
2020
Zhejiang University
2013-2018
Shanghai Ocean University
2011
Chinese Academy of Fishery Sciences
2011
Abstract The high comorbidity between obesity and mental disorders, such as depression anxiety, often exacerbates metabolic neurological symptoms significantly. However, neural mechanisms that underlie reciprocal control of feeding states are largely elusive. Here we report melanocortin 4 receptor (MC4R) neurons located in the dorsal bed nucleus stria terminus (dBNST) engage regulation mentally associated weight gain by receiving GABAergic projections from hypothalamic AgRP onto...
Contrasting to the established role of hypothalamic agouti-related protein (AgRP) neurons in feeding regulation, neural circuit and signaling mechanisms by which they control energy expenditure remains unclear. Here, we report that is regulated a subgroup AgRP send non-collateral projections within dorsal lateral part raphe nucleus (dlDRN) expressing melanocortin 4 receptor (MC4R), turn innervate nearby serotonergic (5-HT) neurons. Genetic manipulations reveal bi-directional this without...
Low bioavailability and stability of 7,8-dihydroxyflavone (7,8-DHF) hinder its potential application in prevention humans' disease. 7,8-DHF loaded nanoliposomes decorated by original, crosslinked glycosylated lactoferrin (LF) were fabricated. The mean particle size spherical LF coating liposomes larger than uncoated with a low polydispersity index, the former had higher encapsulation efficiency (Above 98%). Crosslinked antioxidant activity, storage stability, slow-release ability,...
Comparison of DHF-Z-S and DHF-Z/S nanoparticles with respect to their formation, structural characterization, storage stability <italic>in vitro</italic> bioaccessibility.
A dopaminergic neural circuit projecting from the VTA to hindbrain regulates feeding by transducing meal satiation signals.
In this work, the lactoferrin (LF) was glycosylated by dextran (molecular weight 10, 40, and 70 kDa, LF 10K, 40K, 70K) via Maillard reaction as a stabilizer to establish zein/glycosylated nanoparticles encapsulate 7,8-dihydroxyflavone (7,8-DHF). Three (79.27-87.24 nm) with low turbidity (<0.220) polydispersity index (PDI) (<0.230) were successfully established hydrophobic interactions hydrogen bonding. Compared zein/LF nanoparticles, further increased stability ionic strength (0-500 mM NaCl)...
7,8-DHF was transported across Caco-2 cell monolayers by passive transport with carrier-mediated influx and efflux transporters.
In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) (CMC/S/Z) nanoparticles encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size turbidity, but higher zeta potential, encapsulation efficiency loading capacity...
Oxygen supplementation is life saving for premature infants and COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. Murine studies showed that CYP1B1 enhances, while CYP1A1 CYP1A2 protect from, hyperoxic lung injury. In this study we tested the hypothesis Cyp1b1-null mice would revert hyperoxia-induced transcriptomic changes observed in WT at transcript pathway level. Wild type (WT) C57BL/6J...
Abstract 7,8‐dihydroxyflavone (7,8‐DHF) is a biologically active flavone with various physiological activities, including neuroprotection, anti‐inflammation, and weight loss. Previous studies have found that the efflux protein P‐glycoprotein (P‐gp) significantly affects transepithelial transport of 7,8‐DHF in intestine, resulting its low oral bioavailability. Based on this, this study, Caco‐2 monolayer cell model was used to investigate 14 dietary plant flavonoids as potential P‐gp...
Numerous human and animal studies have reported positive correlation between carcinogen-DNA adduct levels cancer occurrence. Therefore, attenuation of DNA would be expected to suppress tumorigenesis. In this investigation, we report that the antioxidants omega 3-fatty acids, which are constituents fish oil (FO), significantly decreased formation by polycyclic aromatic hydrocarbons (PAHs). B6C3F1 male mice were fed an FO or corn (CO) diet, A/J pre-fed with omega-3 fatty acids eicosapentaenoic...
Lung cancer is the leading cause of death worldwide. Polycyclic aromatic hydrocarbons (PAHs) are metabolized by cytochrome P450 (CYP)1A and 1B1 to DNA-reactive metabolites, which could lead mutations in critical genes, eventually resulting cancer. Omega-3 fatty acids, such as eicosapentaenoic acid (EPA) docosahexaenoic (DHA), beneficial against cancers. In this investigation, we elucidated mechanisms omega-3 acids EPA DHA will attenuate PAH-DNA adducts lung carcinogenesis tumorigenesis...
Obese subjects often exhibit hypersomnia accompanied by severe sleep fragmentation, while emerging evidence suggests that poor quality promotes overeating and exacerbates diet-induced obesity (DIO). However, the neural circuit signaling mechanism underlying reciprocal control of appetite is yet not elucidated. Here, we report a where prokineticin receptor 2 (PROKR2)-expressing neurons within parabrachial nucleus (PBN) brainstem received direct projections from neuropeptide Y Y2...
A large scale isolation and purification of theaflavin (TF) epigallocatechin (EGC) has been successfully developed by tannase-mediated biotransformation combining high-speed countercurrent chromatography. After tannase hydrolysis a commercially available theaflavins extract (TE), the content TF EGC in product (TBP) achieved approximately 3 times enrichment. SEM studies revealed smooth possibility recovery tannase. single 1.5 hours' HSCCC separation for employing two-phase solvent system...
Objectives Exposure to high altitude can affect human health, including the development of adverse cardiovascular effects. This study aimed investigate alterations in cardiac morphology and function high-altitude workers identify risk factors associated with abnormalities. Methods A retrospective cohort was conducted 286 Qinghai-Tibetan Railroad maintenance workers. Participant data were collected from company personnel records. Data on echocardiography diagnosis abnormalities extracted...