A5083365514- Phagocytosis and Immune Regulation
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Chemokine receptors and signaling
- Radiopharmaceutical Chemistry and Applications
- interferon and immune responses
- Pancreatic and Hepatic Oncology Research
- Enzyme function and inhibition
- Multiple Myeloma Research and Treatments
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Geriatric Care and Nursing Homes
- Cancer Treatment and Pharmacology
- Viral Infections and Vectors
- HER2/EGFR in Cancer Research
- PI3K/AKT/mTOR signaling in cancer
- Mass Spectrometry Techniques and Applications
- Nursing education and management
- Prostate Cancer Treatment and Research
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Retinoids in leukemia and cellular processes
Bristol-Myers Squibb (United States)
2010-2022
Exelixis (United States)
2020-2022
Developmental Studies Hybridoma Bank
2012
Castle Peak Hospital
2004
CXCR4 has been identified as a prognostic marker for acute myeloid leukemia (AML) and other malignancies. We describe the development characterization of fully human antibody to its application therapy AML, non-Hodgkin lymphoma (NHL), chronic lymphoid (CLL), multiple myeloma.Human transgenic mice were immunized with CXCR4-expressing cells, antibodies reactive analyzed apoptosis induction ability interfere CXCL12-induced migration calcium flux. In vivo efficacy was determined in NHL, myeloma...
The identification of agonists the stimulator interferon genes (STING) pathway has been an area intense research due to their potential enhance innate immune response and tumor immunogenicity in context immuno-oncology therapy. Initial efforts identify STING focused on modification 2',3'-cGAMP (1) (an endogenous activator ligand) other closely related cyclic dinucleotides (CDNs). While these have successfully identified novel CDNs that progressed into clinic, utility is currently limited...
The multi-receptor tyrosine kinase inhibitor XL092 has been developed to inhibit the activity of oncogenic targets, including MET, VEGFR2, and TAM family kinases TYRO3, AXL MER. Presented here is a preclinical evaluation XL092. causes significant decrease in tumor MET phosphorylation (P < 0.01) murine Hs 746T xenograft models relative vehicle, 96% inhibition VEGFR2 lungs. Dose-dependent growth with was observed various models, dose-dependent regression seen NCI-H441 model. Tumor enhanced...
Antibody–drug conjugates (ADCs) use antibodies to deliver cytotoxic payloads directly into tumor cells via specifically binding the target cell surface antigens. ADCs can enhance anti-tumor effects of antibodies, and increase delivery cancer with a better therapeutic index. An ADC was prepared potent carbamate-containing tubulysin analogue attached an anti-mesothelin antibody Cit-Val dipeptide linker. aniline functionality in created provide site linker attachment amide bond that would be...
ABSTRACT: Despite the unique cultural characteristics of psychiatric nurses in Hong Kong and Thailand little has been written about them or their caring practices. This study set out to examine practices demographic features working these two countries where development nursing education system distinct similarities, yet culture, career paths qualifications differ. The Caring Attributes Questionnaire (CAQ), previously used general samples, was modified validated for administered 275 227...
Abstract CD19 is an attractive target for immunotherapy. The expression of restricted to B cells and follicular dendritic cells. In cells, initiated at the point lineage commitment continues through pre mature cell differentiation. Expression lost during terminal differentiation plasma in B-lineage that have undergone neoplastic transformation, making it a useful marker diagnosis treatment derived lymphomas leukemias, including non-Hodgkin's lymphoma (NHL), acute lymphocytic leukemia (ALL)...
Abstract Introduction: A method to study biodistribution of adduct forming antibody drug conjugates (ADCs) by LC-MS Description: ADCs are increasingly used deliver cytotoxic payloads tumor cells. While the targeted approach has vastly improved toxicity profiles these drugs, it is still important understand bio-distribution and enhanced localization this offers. Radio-labeled methods most reliable bio-distribution, but may not be able differentiate between that present in tissue from those...
Abstract Background: Cabozantinib, an inhibitor of MET, VEGFR2, AXL, and MER, has shown significant clinical activity in multiple solid tumors, both alone combination with immune checkpoint inhibitors (ICIs). XL092 a similar target profile to cabozantinib but significantly shorter half-life pharmacokinetic properties suitable for once daily oral dosing (Hsu, Eur J Cancer, 2020). In preclinical studies, the anti–PD-1 exhibited greater anti-tumor than either agent alone. Here, we describe...
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