A5039978139- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
Martin Luther University Halle-Wittenberg
2011-2014
Betulinic acid (BA) is a novel antineoplastic agent under evaluation for tumor therapy. Because of the selective cytotoxic effects BA in cells (including gliomas), combination this with conservative therapies (such as radiotherapy and chemotherapy) may be useful. Previously, irradiation hypoxic conditions had never been studied. In study, 3 to 30 μM on cytotoxicity, migration, protein expression PARP, survivin HIF-1α, well radiosensitivity normoxic were analyzed human malignant glioma cell...
Betulinic acid (BA), a pentacyclic triterpene, represents new therapeutic substance that has potential benefits for treating glioblastoma. Recently, strategies producing BA derivatives with improved properties have evolved. However, few studies examined the combination of or using radiotherapy. The effects two derivatives, NVX-207 and B10, on cellular radiobiological behavior were analyzed glioblastoma cell lines (U251MG, U343MG LN229). Based IC50 values under normoxic conditions, we...