A5084155931- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- interferon and immune responses
University of Chinese Academy of Sciences
2022-2025
Shanghai Institute of Nutrition and Health
2022-2025
Binzhou Medical University
2024
Binzhou University
2024
Soochow University
2022
The First People's Hospital of Changzhou
2022
Abstract Macrophages that acquire an immunosuppressive phenotype play a crucial role in establishing the pre-metastatic niche (PMN), which is essential for facilitating breast cancer metastasis to distant organs. Our study showed increased activity of aryl hydrocarbon receptor (AHR) lung macrophages plays PMN cancer. Specifically, AHR activation led high expression PD-L1 on by directly binding promoter Pdl1 . This upregulation promoted differentiation regulatory T cells (Tregs) within PMN,...