A5028828438- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Magnesium Alloys: Properties and Applications
- Ubiquitin and proteasome pathways
- Atherosclerosis and Cardiovascular Diseases
- melanin and skin pigmentation
- Sulfur Compounds in Biology
- dental development and anomalies
- Neuropeptides and Animal Physiology
- Aluminum Alloys Composites Properties
- Glycosylation and Glycoproteins Research
- Hair Growth and Disorders
- Platelet Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Heat shock proteins research
- Analytical Chemistry and Sensors
- Proteoglycans and glycosaminoglycans research
- Mitochondrial Function and Pathology
- Apelin-related biomedical research
- Bone Tissue Engineering Materials
- Non-Invasive Vital Sign Monitoring
- Neuroinflammation and Neurodegeneration Mechanisms
Jilin University
2014-2025
Jilin Medical University
2025
Shanghai Institute of Nutrition and Health
2022-2024
University of Chinese Academy of Sciences
2022-2024
Stomatology Hospital
2014-2023
Soochow University
2018
Autologous platelet concentrates (APC) represent a class of personalized regenerative materials for vascularized tissue regeneration. However, shortcomings including poor controllability gel formation, lack reactive oxygen species (ROS) scavenging ability, and deficient anti-inflammatory capacity restrict the healing outcomes APC. This study proposes an APC-based synergistic platform (CurCDs@iPRF-MA) treatment chronic wounds in diabetes. Such is composed injectable platelet-rich fibrin...
Abstract Cerebral ischemia/reperfusion (I/R) injury is an obstacle in treating ischemic stroke effectively. miR-98-5p has been reported to have the ability of reducing myocardial I/R injury. To explore function cerebral I/R, we established mice model middle artery occlusion and reperfusion (MCAO/R). The level was found be downregulated serum patients brain tissues MCAO/R mice. Examination indicated that upregulating alleviated infarction Moreover, upregulation reduced reactive oxygen species...
Cartilage defects are some of the most common causes arthritis. lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized extracellular matrix (ECM) derived from autologous, allogenic, xenogeneic mesenchymal stromal cells (MSCs) can effectively restore integrity.
Abstract The destruction of periodontal alveolar bone (AB) caused by periodontitis is regarded as one the major reasons for tooth loss. inhibition resorption and regeneration lost AB are desirable outcomes in clinical practice but remain challenge. use mesenchymal stem cells (MSCs) current approach achieving true restoration defects (ABD). Antler (AnSC) capable renewing a huge mammalian bony appendage, deer antler, suggesting an unparalleled potential regeneration. Herein, we investigated...
Background: Dietary tyrosine regulating melanoma progression has been well-recognized. However, whether tyrosine-based melanin anabolism contributes to pulmonary and cerebral organotropic colonization of remains elusive. Furthermore, approaches based on targeting tyrosinase activity inhibiting multi-organ metastasis cells need be designed validated. Methods: Patients derived mouse B16 with different pigmentation were employed in this investigation. Tyrosine content dynamics tumors multiple...
Niche for stem cells profoundly influences their maintenance and fate during tissue homeostasis pathological disorders; however, the underlying mechanisms tissue-specific features remain poorly understood. Here, it is reported that fatty acid desaturation catabolized by stearoyl-coenzyme A desaturase 1 (SCD1) regulates hair follicle (HFSCs) growth maintaining bulge, niche HFSCs. Scd1 deletion in mice results abnormal growth, an effect exerted directly on keratin K14
Abstract Macrophages that acquire an immunosuppressive phenotype play a crucial role in establishing the pre-metastatic niche (PMN), which is essential for facilitating breast cancer metastasis to distant organs. Our study showed increased activity of aryl hydrocarbon receptor (AHR) lung macrophages plays PMN cancer. Specifically, AHR activation led high expression PD-L1 on by directly binding promoter Pdl1 . This upregulation promoted differentiation regulatory T cells (Tregs) within PMN,...
As a rare hematological malignancy, T‑cell prolymphocytic leukemia (T‑PLL) has high mortality rate. However, the comprehensive mechanisms of underlying pathogenesis T‑PLL are unknown. The purpose present study was to investigate based on bioinformatics analysis. differentially expressed genes (DEGs) between blood cell samples and normal peripheral were investigated using GSE5788 Affymetrix microarray data from Gene Expression Omnibus database. To functional changes associated with tumor...
This paper tackles the problem of noise suppression during vital sign signal monitoring. Physiological monitoring is a significant and promising medical method, wearable devices based on piezoelectric polymer sensors are trending way for their advantages being flexible in shape, portable to use, comfortable wear. However, this raises question that measured contains much more components. To avoid following shortcoming low ratio (SNR), method improved wavelet threshold empirical mode...
Deer antlers are male secondary sexual characters that develop to become bone; they unique appendages that, once lost, can fully regenerate from the permanent bony protuberances or pedicles. Pedicle periosteum (PP) is tissue gives rise regenerating with three differentiation stages, namely, dormant (DoPP), potentiated (PoPP), and activated (AcPP). Thus far, transition PoPP AcPP has not been studied. Our results showed cells maintained their original stem cell features by expressing...
To discover the populations of mesenchymal stem cells (MSCs) derived from different layers human maxillary sinus membrane (hMSM) and evaluate their osteogenic capability.
In this study, a kind of Mg-4Zn-3HA alloy was investigated as biodegradable material. Magnesium alloys can be totally degraded in the body, and their corrosion products are not deleterious to surrounding tissues. We conducted comprehensive investigation microstructure, mechanical properties, vitro degradation assessments, cytotoxicity evaluations alloy. Our observations microstructure show that is porous, its structural characteristic resembling nature bone make suitable for use implants....