A5019435986- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Lipid Membrane Structure and Behavior
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Protein purification and stability
- Advanced Biosensing Techniques and Applications
- Acute Kidney Injury Research
- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- IL-33, ST2, and ILC Pathways
- Cardiac Arrest and Resuscitation
- Fatty Acid Research and Health
- Lipoproteins and Cardiovascular Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Eosinophilic Esophagitis
- Healthcare Systems and Public Health
- Cardiac Arrhythmias and Treatments
National Medical Research Center of Cardiology
2019-2024
Institute of Experimental Cardiology
2013-2018
Moscow State University of Medicine and Dentistry
2016
Lomonosov Moscow State University
2003
Moscow State University of Fine Chemical Technologies
2001
Moscow Architectural Institute
2001
Alterations of heart rhythm are a common clinical event. They can be caused by almost any kind disorder. Atrial fibrillation (AF) is the most type abnormal rhythm. Prevalence AF in general population 1-2%, and given that incidence rate continues to increase it predicted number patients will doubled within next 50 years. This review provides recent diagnostic treatment methods, including both unique domestic antiarrhythmic drugs non - drug methods for which were developed implemented practice...
To study the possibilities of previously diagnosing acute renal damage in patients with decompensation chronic heart failure reduced systolic function using biomarkers injury.The included 60 (62.0±11.1 years) HADS (BNP >500 pg/ml) and a left ventricular ejection fraction (LV 27.05% [23.25; 32.75], c FC III-IV NYHA). The level creatinine, urea, uric acid, albumin serum was determined all patients, as well number biomarkers: lipocalin associated neutrophil gelatinase (NGAL) cystatin C...
The interactions of a water-soluble nonmembrane protein aprotinin with multilamellar vesicles (MLV) and small unilamellar (SUV) from soybean phospholipids were studied using Sephadex G-75 gel chromatography combined different methods the analysis eluate fractions (fluorescence, light-scattering, turbidity; 31P NMR spectroscopy). composition liposomes mainly containing phosphatidylcholine (PC) was varied by addition phosphatidylethanolamine (PE), phosphatidylinositol (PI)...
This study aimed to assess the level of anti-1-adrenergic receptor autoantibodies in patients with ventricular arrhythmias no signs organic heart disease and presence cardiovascular pathology comparison a group healthy volunteers.The included 44 ("idiopathic"), 34 diagnosed dilated cardiomyopathy (DCM) inflammatory origin, 35 coronary arrhythmias, 12patients 19 volunteers (control group). The against 1-adrenergic was determined by developed competitive cell-based enzyme-linked immunosorbent...
To evaluate the effect of Sacubitril/Valsartan (S/V) on functional status, systolic and diastolic function left ventricle (LV), tolerability therapy to determine predictors its effectiveness in patients with cancer therapy-related heart failure (СTRHF). Forty 58 [46; 65.5] years age HF associated anthracycline-containing were enrolled. Clinical examination, echocardiography, assessment potassium creatinine levels performed at baseline after 6 months S/V therapy. NYHA class (FC) improvement...
The detection of autoantibodies against the β1-adrenergic receptor (ADRB1 Ab) in blood patients and monitoring levels these antibodies is an urgent need clinical practice. solid-phase enzyme-linked immunosorbent assay (ELISA), using ADRB1 native conformation as antigen, seems to be most suitable for this task. We have previously tested various amphipathic polymers their ability solubilize form nanodiscs so that retains its antigenic properties. aim present work was investigate ligand binding...
We aimed to assess autoantibodies M2-cholinoceptors (M2-CR) in patients with paroxysmal lone atrial fibrillation (AF) and AF arterial hypertension (AH).100 84 AH were included. Patients underwent clinical blood urinalysis, assessment of biochemistry panel, 12-lead ECG, 24-hour Holter monitoring, echocardiography stress - testing (treadmill or echocardiography). Assessment IgM IgG M2-CR was performed by indirect immunoenzyme assay. The following peptide molecules used as epitopes for...
The development of a reliable and easily used diagnostic test for measuring autoantibodies to ?1-adrenergic receptor (?1ADR Ab) in patient blood is an unmet clinical need. enzyme-linked immunosorbent assay (ELISA) considered as the most appropriate method this task. In ELISA, use peptides corresponding various fragments amino acid sequence ?1ADR antigens leads inadequate results β1ADR Ab appear recognize conformationally dependent epitopes that are generated during formation unique tertiary...
Background: According to numerous studies, from 30% 50% of patients with chronic heart failure (CHF) are resistant cardiac resynchronization therapy (CRT) and contractility modulation (CCM), despite their careful selection in accordance current guidelines. It is interest study neurohormones characterizing myocardial (NT-proBNP) fibrosis (sST2) as potential additional markers CHF patients' “response” CRT CCM. Aim: To evaluate the use NT-proBNP sST2 biomarkers combined transthoracic...
В статье приведены два клинических примера лечения пациентов после перенесенной острой декомпенсации сердечной недостаточности с использованием мониторирования концентрации нового биомаркера (СН) — растворимого sST2-рецептора. Обсуждены преимущества этого перед натрийуретическими пептидами, которые позволили достичь успеха в лечении СН высокого риска In article presents 2 clinical cases of patient’s treatment after acute decompensated heart failure using concentration monitoring a new...
Adipose tissue is considered as an endocrine organ that affects the metabolic health of a person. Unified quantitative indicators fat depots according to computed tomography have not been determined. Determination critical level intraabdominal, subcutaneous, epicardial, perivascular associated with syndrome in young adults scientific and practical interest. The aim study was evaluate distribution relationship profile different phenotypes, determine (MS). M aterials methods: included 132...
Aim To study the effectiveness of a treatment based on monitoring soluble ST2 receptor (sST2) concentration in patients with chronic heart failure (CHF) reduced left ventricular ejection fraction (LVEF) after acute decompensated (ADHF). Material and methods The included 37 hospitalized for ADHF LVEF ≤40% sST2 ≥37.8 ng/ml at time discharge from hospital. Patients were randomized into two groups: (sST2M) group (19 patients) standard therapy (ST) (18 patients). follow-up period was 12 months....
Abstract Introduction Atrial fibrillation (AFib) is the most frequenly encountered arrhythmia. In majority of cases AFib occurs in patients with cardiovascular diseases such as arterial hypertension (AH). 10–15% absense comorbidities structurally normal heart. It reffered to “lone AFib” and cause this arrhythmia remains unknown. Activation cardiac M2-actylcholinoreceptors (M2-CR) leads decrease duration atrial refractory periods that may contribute development AFib. Autoantibodies against...
Autoantibodies to 1-adrenergic receptor may play a role in the development of certain cardiovascular system diseases.Synthetic peptide-based enzyme-linked immunosorbent assay (eliSA), traditionally used for detection such antibodies, does not allow obtain adequate data, probably due poor similarity peptide conformations spatial structure extracellular regions.Aim study: improve eliSA method autoantibodies 1 adrenergic by separate determination igG1, igG2, igG3, igG4, igM and igA autoantibody...
Aim . To study the changes in N-terminal pro-brain natriuretic peptide (NT-proBNP) and growth stimulation gene-2 (sST2) to predict isolated episodes of ventricular tachyarrhythmias (VTA) electrical storm (ES) patients with systolic heart failure implanted cardioverter-defibrillators, cardiac resynchronization therapy (CRT) defibrillators, as well contractility modulation (CCM) devices. Material methods The included 69 (mean, 59; women, 10; mean age, 59±13 years) class I-III HF ischemic...