A5047546963- Protein Structure and Dynamics
- Hemoglobin structure and function
- Enzyme Structure and Function
- Alzheimer's disease research and treatments
- RNA and protein synthesis mechanisms
- Proteins in Food Systems
- Erythrocyte Function and Pathophysiology
- Bacterial Genetics and Biotechnology
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Porphyrin Metabolism and Disorders
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Cholinesterase and Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Pharmacological Effects and Assays
- Bioinformatics and Genomic Networks
- Bipolar Disorder and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- RNA Research and Splicing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuropeptides and Animal Physiology
Institute of Protein Research
2010-2024
Russian Academy of Sciences
2008-2011
The Sm and Sm-like proteins are widely distributed among bacteria, archaea eukarya. They participate in many processes related to RNA-processing regulation of gene expression. While the function bacterial Lsm protein Hfq eukaryotic Sm/Lsm is rather well studied, role Archaea investigated poorly. In this work, RNA-binding ability an archaeal Hfq-like from Methanococcus jannaschii has been studied by X-ray crystallography, anisotropy fluorescence surface plasmon resonance. It found that MjaHfq...
Engineering of amyloid structures is one the new perspective areas protein engineering. Studying process formation can help find ways to manage it in interests medicine and biotechnology. One promising candidates for structural basis artificial functional fibrils albebetin (ABB), an engineered under leadership O.B. Ptitsyn. Various aspects this some methods controlling are investigated paper. Four stages by from first non-fibrillar aggregates mature large micron-sized complexes have been...
The creation of new proteins by combining natural domains is a commonly used technique in protein engineering. In this work, we have tested the possibilities and limitations using circular homo-oligomeric Sm-like as basis for attaching other domains. Attachment to such stable base should bring target together keep them correct mutual orientation. We chose homoheptameric from Sulfolobus acidocaldarius backbone apical domain GroEL chaperone study. This itself, separated rest molecule, does not...
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The detection of autoantibodies against the β1-adrenergic receptor (ADRB1 Ab) in blood patients and monitoring levels these antibodies is an urgent need clinical practice. solid-phase enzyme-linked immunosorbent assay (ELISA), using ADRB1 native conformation as antigen, seems to be most suitable for this task. We have previously tested various amphipathic polymers their ability solubilize form nanodiscs so that retains its antigenic properties. aim present work was investigate ligand binding...
The formation of amyloid fibrils is one the variants self-organization polypeptide chains. For aggregation, solution must be oversaturated with proteins. interface liquid (solution) and solid (vessel walls) phases can trigger adsorption protein molecules, resulting oversaturation initiate conformational transitions in them. In any laboratory experiment, we cannot exclude presence surfaces such as walls vessels, cuvettes, etc. However, many works devoted to study formation, this feature not...