A5030745767- Connective Tissue Growth Factor Research
- Nitric Oxide and Endothelin Effects
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Systemic Sclerosis and Related Diseases
- Biomedical Research and Pathophysiology
- Celiac Disease Research and Management
- Chronic Myeloid Leukemia Treatments
- Connective tissue disorders research
- Renin-Angiotensin System Studies
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Rheumatoid Arthritis Research and Therapies
- Cardiac and Coronary Surgery Techniques
- Pancreatic function and diabetes
- Autoimmune Bullous Skin Diseases
- Trypanosoma species research and implications
- Dupuytren's Contracture and Treatments
- Metabolism, Diabetes, and Cancer
- Pregnancy and Medication Impact
- Monoclonal and Polyclonal Antibodies Research
- Angiogenesis and VEGF in Cancer
- Cardiac Ischemia and Reperfusion
- Inflammatory Myopathies and Dermatomyositis
- Metabolism and Genetic Disorders
Pfizer (United States)
2016-2025
Ibero American University
2016
Medizinische Hochschule Hannover
1987-2015
AstraZeneca (United Kingdom)
2014
AstraZeneca (United States)
2013
Eli Lilly (United States)
2007
University of Iowa
2007
Monash University
2007
Hospital Universitari Germans Trias i Pujol
2007
University of British Columbia
2007
Rationale: Evidence suggests that tumor necrosis factor (TNF)-α plays an important role in the pathophysiology of sarcoidosis.Objectives: To assess efficacy infliximab sarcoidosis.Methods: A phase 2, multicenter, randomized, double-blind, placebo-controlled study was conducted 138 patients with chronic pulmonary sarcoidosis. Patients were randomized to receive intravenous infusions (3 or 5 mg/kg) placebo at Weeks 0, 6, 12, 18, and 24 followed through Week 52.Measurements Main Results: The...
Endothelin (ET)-1 has potent vascular effects. Two endothelin receptors have been cloned, namely, the ETA receptor, which preferentially binds ET-1, and ETB equally ET-1 ET-3 sarafotoxin S6c. We characterized receptor subtypes on smooth muscle endothelium of isolated human internal mammary artery (IMA) vein (IMV) porcine coronary (PCA) using antagonists FR139317 BQ-123, ligand S6c, ETA/ETB antagonist Ro 47-0203 (bosentan).In endothelium-denuded IMA PCA less so in IMV, BQ-123 (in only)...
Background —NO regulates vascular tone and structure, platelets, monocytes. NO is synthesized by endothelial synthase (eNOS). Endothelial dysfunction occurs in atherosclerosis. Methods Results —With a porphyrinic microsensor, release was measured atherosclerotic human carotid arteries normal mammary obtained during surgery. eNOS protein expression analyzed immunohistochemistry. In arteries, the initial rate of after stimulation with calcium ionophore A23187 (10 μmol/L) 0.42±0.05 (μmol/L)/s...
Background and Purpose— A previous randomized, placebo-controlled, double-blind study suggested that abciximab may be safe effective in treatment of acute ischemic stroke. The current phase 3 was planned to test the relative efficacy safety patients with stroke within 5 hours since symptoms onset. Methods— An international, trial tested intravenous administration 2 cohorts using stratification variables time onset severity. enrollment 1800 patients. primary cohort enrolled those who could...
Background Atherosclerosis affects certain but not all vascular beds of the human circulation. Its molecular mechanisms are only partially understood. Human connective tissue growth factor (hCTGF) is a novel cysteine-rich, secreted polypeptide. hCTGF implicated in formation, which may play an important role atherosclerosis. Methods and Results By using differential cloning technique, we isolated cDNA clone from aorta library, identical to hCTGF. Northern analysis shows that mRNA was...
Abstract There is increasing evidence that oxidative stress of pathophysiological importance in cardiovascular disease. Mechanical forces such as pulsatility may also contribute. Using human coronary artery smooth muscle cells (HCAS), we tested the hypothesis stretch-induced cell proliferation associated with stress. Stretch induced DNA synthesis HCAS, and this was prevented by antioxidants N -acetylcysteine pyrrolidinedithiocarbamate (PDTC). Pulsatile stretch increased superoxide production...
BackgroundHidradenitis suppurativa (HS) is a debilitating, inflammatory skin disease with limited treatment options and partially understood pathophysiology. Using an umbrella trial design, three kinase inhibitor immunomodulators different mechanisms of action were evaluated.MethodsThis phase 2a, double-blind, parallel-group enrolled adults moderate to severe HS who then randomly assigned (1:1:1:1) once-daily brepocitinib 45 mg (a JAK1/TYK2 inhibitor), zimlovisertib 400 (an IRAK4...
Connective tissue growth factor (CTGF) is a member of an emerging CCN gene family that implicated in various diseases associated with fibro-proliferative disorder including scleroderma and atherosclerosis. The function CTGF human cancer largely unknown. We now show induces apoptosis the breast cell line MCF-7. mRNA was completely absent MCF-7 but strongly induced by treatment transforming β (TGF-β). TGF-β itself MCF-7, this effect reversed co-treatment antisense oligonucleotide....
Background —Internal mammary artery (IMA) bypass grafts have a higher patency than saphenous vein (SV) grafts. Intimal hyperplasia of SV is due to smooth muscle cell (SMC) proliferation and migration. We hypothesized that different SMC growth activity exists in IMA SV, which may explain the patencies arterial venous Methods Results —SMCs were isolated from by explant culture stimulated with serum or platelet-derived factor-BB (PDGF-BB). Cell was analyzed outgrowth rate, 3 H-thymidine...
Abstract In a prospective study (Cytotoxic Drug Study II), 18 children with steroid dependent nephrotic syndrome and toxicity were treated cyclophosphamide (2 mg/kg body weight/day) for 12 weeks in combination reducing doses of prednisone (group A). This group was compared retrospectively syndrome, studied as part the Cytotoxic I, who had received eight B). There no differences between groups age at onset entry into study, duration before study. The number relapses during six months...
Connective tissue growth factor (CTGF) is overexpressed in a variety of fibrotic disorders such as renal fibrosis and atherosclerosis. Fibrosis common final pathway diseases diverse etiology, including inflammation, hemodynamics, metabolic injury. Mechanical strains stretch, shear stress, static pressure are possible regulatory elements CTGF expression. In this study, we examined the ability to modulate gene expression cultured human mesangial cells. Low (40–80 mm Hg) stimulated cell...
Connective tissue growth factor (CTGF) is expressed at very high levels particularly in the shoulder of human atherosclerotic lesions but not normal blood vessels. Thus, CTGF may be important regulation vascular smooth muscle cell function atherosclerosis, its precise role remains elusive.Full-length cDNA driven by a cytomegalovirus promoter was transiently transfected into cultured aortic cells (HASCs). Northern and Western analysis demonstrated that overexpressed these 48 hours after...
Mesangial cells are thought to play a central role in the renal complications of diabetes mellitus. Insulin-like growth factor I (IGF-I) has been found promote mesangial cell proliferation and regulate normal function an autocrine and/or paracrine fashion. To gain further insight into potential regulatory IGF-I may diabetes, receptors were analyzed isolated from diabetic mice (db/db) their control littermates (db/m). db/db exhibited higher levels compared db/m mice. Insulin not detectable...
<h3>Objectives</h3> OSKIRA-4 evaluated the efficacy of fostamatinib monotherapy versus placebo on signs and symptoms rheumatoid arthritis over 6 weeks by Disease Activity Score C reactive protein (DAS-28(CRP)) assessed non-inferiority to adalimumab at Week 24 DAS-28(CRP). <h3>Methods</h3> Overall, 279 patients not currently taking disease-modifying antirheumatic drugs were randomised to: (A) 100 mg twice daily for plus injection every 2 (PBOI); (B) 4 weeks, then 150 once up 24, PBOI; (C) (D)...
Lüscher, Thomas F.; Oemar, Barry S.; Boulanger, Chantal M.; Hahn, Alfred W.A. Author Information
The nature of kidney lesions in BD IX rats infected with Trypanosoma brucei was investigated. Proteinuria developed and increased up to 236 +/- 35 mg/24 hr at 7 wk after the infection. Antibodies were found be deposited along glomerular basement membrane (GBM) predominantly a linear fashion, which changed more granular pattern At this stage disease, electron-dense deposits subendothelially GBM. In sera eluates diseased rats, anti-GBM antibodies present. Enzyme-linked immunosorbent assay...