This was a retrospective study examining the psychosocial morbidity of patients before and after ear reconstruction. Semistructured questionnaires were sent to 90 patents with significant congenital or acquired auricular deformity 2.2 years (range 3 months 5 years) following autogenous osteointegrated Sixty-two (69%) responded. Twenty-two below 12 years, who had undergone reconstructive surgery, also completed Childhood Experience Questionnaire. These compared cohort 362 normal patients....

BackgroundEven though the benefit of free tissue transfer is uncontested in complex reconstructive cases, vascular compromise and/or flap failure remain a challenge for surgeon and identification possible risk factors can aid preoperative planning. The aim this study was to identify individual leading transfers single institution over period 10 years create an index predicting these problems, as well finding predictors other postoperative complications.MethodsData from all patients...

It is perceived that fuller lips are more attractive, and hence lip augmentation has become common in esthetic plastic surgery. Numerous materials have been used, including collagen, autologous adipocytes, recently Restylane; however, little data exist on what comprises esthetically beautiful lips. Photographs of 28 models from fashion magazines were scanned to obtain digital images. These selected strictly, using only exactly anterior-facing pictures. Using image analysis software, a range...

Mechanisms behind the onset and progression of Dupuytren’s disease are poorly understood. Both myofibroblasts transforming growth factor beta 1 (TGF-β ) have been implicated. We studied fibroblast cultures derived from nodules or cords contracture tissue to determine proportion present in comparison with flexor retinaculum cultures. identified by immunohistochemical staining for α-SMA. then investigated effects TGF-β stimulation on these fibroblasts. Basal myofibroblast/fibroblast...

Velopharyngeal incompetence occurs in approximately 25% of cases after primary palatoplasty. There is controversy regarding the best method surgical management velopharyngeal incompetence. Between 1986 and 1993, 13 children with palatoplasty underwent Furlow Z-plasty repair. All were assessed by a speech therapist videofluoroscopy pre- postoperatively. The was performed at mean age 7.8 years (range, 4–12 years). Eleven achieved normal resonance, all demonstrated improved function on...

ABSTRACT The multipotent growth factor transforming (TGF)‐β1 is consistently linked with fibrosis and scarring. perfect (scarless) healing of cutaneous wounds in early gestational age fetuses proposed to be due this tissue's predominance the TGF‐β3 isoform over profibrotic TGF‐β1 2. Nevertheless, present during wound fetus recently we demonstrated that relevant intracellular signaling pathways are activated (albeit transiently) on TGF‐β1stimulation. This study aimed determine whether has...

Giant cell tumours of tendon sheath vary from solitary nodules to a multinodular variety that exhibits local infiltration. Recent advances in molecular oncology have defined gene, nm23, expressed normal cells which is responsible for inhibiting The aim this study was investigate the expression nm23 series 52 giant using immunohistochemistry and assess its prognostic potential, absent 21% associated with highly significant risk recurrence ( P<0.0001). Multivariate analysis outcome showed...

Background: Fibroproliferative disorders, such as Dupuytren’s contracture of the hand, are characterized by excessive production collagen. 5-Fluorouracil has been used to treat fibroproliferative disorders eye and skin is thought inhibit thymidylate synthetase blocking DNA replication. shown down-regulate fibroblast proliferation differentiation in vitro. Methods: This study investigated dose-dependent effect 5-fluorouracil on extracellular matrix production. Fibroblasts were derived from...

Flexor tendon injuries in adults differ from those children. 38 children (22 male and 16 female) with a mean age of 6.7 years were treated for flexor by primary suture controlled mobilization between 1985 1992. 53 tendons injured (average 1.5 digits per patient) the injury most commonly affected little finger (23 patients). 60% occurred zone 2. Using Lister’s criteria, 82% achieved excellent or good results. Repair both FDS FDP was better than repair alone, even There three ruptures (all...