A5057440460- Genomic variations and chromosomal abnormalities
- Chromosomal and Genetic Variations
- Prenatal Screening and Diagnostics
- Genetic diversity and population structure
- Jewish and Middle Eastern Studies
- Bat Biology and Ecology Studies
- Acute Myeloid Leukemia Research
- Animal Ecology and Behavior Studies
- Animal Diversity and Health Studies
- Acute Lymphoblastic Leukemia research
- Middle East Politics and Society
- Evolution and Paleontology Studies
- Environmental and Biological Research in Conflict Zones
- Transboundary Water Resource Management
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Chromatin Dynamics
- Lymphoma Diagnosis and Treatment
- Species Distribution and Climate Change
- Genetic Syndromes and Imprinting
- Renal and related cancers
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Conservation, Biodiversity, and Resource Management
- Wildlife Ecology and Conservation
- Genomics and Rare Diseases
Bethlehem University
2014-2024
Institute for Biodiversity
2021-2024
Oregon Department of Environmental Quality
2022
Cornell University
2020
Birzeit University
2014
University of Southampton
2011
Duke University
1992-2006
John B. Pierce Laboratory
2006
Yale University
2000-2006
Dana-Farber Cancer Institute
1999-2006
PURPOSE: To examine the effect of single compared with repetitive (at least three) cycles high-dose cytarabine after induction therapy for patients acute myeloid leukemia (AML) who have t(8;21)(q22;q22) karyotype. PATIENTS AND METHODS: Patients entered onto study had AML and t(8;21) attained a complete remission on four successive Cancer Leukemia Group B studies. In these studies, either ≥ three or one cycle was administered, followed by sequential cyclophosphamide/etoposide...
Obtaining primary human endometrial stromal cells (HESCs) for in vitro studies is limited by the scarcity of adequate material and inability to passage these culture long periods. Immortalization would greatly facilitate studies; however, process immortalization often results abnormal karyotypes aberrant functional characteristics. To meet this need, we have introduced telomerase into cultured HESCs prevent normal shortening telomeres observed adult somatic during mitosis. We now developed...
PURPOSE To examine the prognostic significance of extramedullary leukemia (EML) at presentation in patients with t(8;21)(q22;q22) karyotype. PATIENTS AND METHODS Consecutive t(8;21) treated on Cancer and Leukemia Group B de novo acute myeloid (AML) treatment studies were examined for presence EML (granulocytic sarcoma, subcutaneous nodules, cutis, or meningeal leukemia) initial presentation. Clinical features outcome without compared. RESULTS Of 84 t(8;21), eight (9.5%) had manifesting as...
RET/papillary thyroid cancer (PTC) is a marker for papillary carcinoma, but its specificity has been questioned because of the disputed identification RET/PTC in Hashimoto's thyroiditis (HT), oncocytic tumors, and other lesions.The objective this study was to determine 1) whether occurs nonneoplastic follicular cells HT, 2) recombination rate tumors.Forty-three samples from 31 cases HT were examined using interphase fluorescence situ hybridization (FISH) with RET probes spanning breakpoint...
Distributional and ecological data were given to all rodents of Jordan. The rodent fauna Jordan consists 28 species with 20 genera in eight families (Cricetidae, Dipodidae, Gliridae, Hystricidae, Muridae, Myocastoridae, Sciuridae,and Spalacidae), including four introduced species.Keys for provided, along diagnosis each cranial illustrations most species. Habitat preference zoogeographic affinities wereanalyzed, as well their status conservation.Threat categories causes threats on the also...
Many conflicts in Western Asia over the past 75 years left devastation and refugees last war on Gaza Strip is a good example. Our interests as environmentalists are effects of conflict (including active conflict, pre-conflict activities, post-conflict impact). Here, we review impacts Palestinian environment activities since 1948 (establishment state Israel): (such training sites, military bases, installation), during (use different munitions, pollution, altering habitats), post-conflicts...
Cytogenetic analysis of spontaneous abortion samples can be limited by culture failure. Failure to grow in vitro has traditionally been suspected due vivo death tissue associated with (SAB) or simply technical factors growth culture.We used array comparative genomic hybridization (array CGH) investigate chromosomal imbalances products conception that failed vitro.Our data on 26 cases SABs are compared and contrasted published cytogenetic findings following culture. The results revealed...
Preface 1 Introduction Chapter 2 What we want: Plurality, Justice, Human Rights 3 The Logic of Popular Resistance 4 Local Context 5 during the Ottoman Rule 6 Balfour, Buraq, and Zionist Buildup (1917-1935) 7 Great Revolt 1936-1939 8 Devastation to Nakba 1939-1948 9 From Naksa 1948-1967 10 One State Oppression 1967-1986 11 Intifadat AlHijara 1987-1993 12 Oslo Years AlAqsa Intifada 13 Boycotts, Divestments Sanctions 14 Conclusions Outlook Future Appendix. Examples local popular resistance...
We surveyed and identified species of lady beetles from the West Bank to document their geographic distribution understand ecological significance. This study documents presence 35 Coccinellidae in 19 genera belonging 10 tribes 6 subfamilies. Seven (mostly very rare), out documented, are recorded for first time area studied. These Nephus (Bipunctatus) bipunctatus, N. crucifer, Scymnus (Scymnus) interruptus, S. (Parapullus) abietis, (Neopullus) limbatus, nigropictus, (Pullus) suturalis....
Genetic defects of the zygote, such as chromosome aberrations, are most frequent causes abnormal embryonic development and spontaneous abortion. However, underlying mechanisms remain unknown. Chromosome aberrations likely cause changes in placental morphology function (such size, shape, vascularity, presence trophoblastic inclusion). We postulated that may affect rates cell proliferation or programmed death (apoptosis) during differentiation chorionic villi. To address these questions, we...
The p53 tumor suppressor is activated in response to a variety of cellular stress signals, although specific vivo signals that trigger suppression are unknown. In mouse thymocytes, where inactivation leads tumorigenesis, several observations suggest V(D)J recombination T-cell receptor (TCR) loci could provide DNA damage signal triggering p53-dependent apoptosis and suppression. Inactivation would allow driven mutation additional cancer genes, facilitating tumorigenesis. Here, we show mice...
The Cancer and Leukemia Group B has performed central review of karyotypes submitted by institutional cytogenetics laboratories from patients with acute myeloid (AML) lymphoblastic (ALL) leukemia since 1986. We assessed the role karyotype in maintaining accurate, high quality cytogenetic data for clinical translational studies using two criteria: proportion rejected (i.e. inadequate), and, among accepted adequate) cases, whose interpretation was changed on review. compared first four years...
Over 110 species of mammals roamed the forests, mountains, and deserts this ancient Land Canaan Jordan, Israel, Syria, Lebanon, Palestine. Their impact on humans can be seen in cave drawings made by Neanderthal inhabitants northern Palestine some 200,000 years ago gleaned from writings all Near Eastern civilizations.In recent centuries, encroachment an increasing human population has resulted extinction several aurochs (wild ox), red deer, onagers, Syrian wild asses roebucks (roe deer),...