A5047426842- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Hormonal Regulation and Hypertension
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Cholesterol and Lipid Metabolism
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Neurogenetic and Muscular Disorders Research
- Estrogen and related hormone effects
- Adipose Tissue and Metabolism
- Lysosomal Storage Disorders Research
- Nuclear Receptors and Signaling
- Phosphodiesterase function and regulation
Universidad de Navarra
2012-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2016-2025
Ikerbasque
2024-2025
Policlínica Gipuzkoa
2024
Universidad Publica de Navarra
2024
Biogipuzkoa Health Research Institute
2016-2024
Instituto de Salud Carlos III
2017-2024
Ministry of Economy, Industry and Competitiveness
2017-2021
Karolinska Institutet
2008-2017
Centro de Investigación Biomédica en Red
2016-2017
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as marker of 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) the Swedish BioFINDER study 1,464). Plasma was significantly increased all cortical amyotrophic lateral sclerosis atypical parkinsonian disorders. We...
Levels of the cyclic nucleotides guanosine 3', 5'-monophosphate (cGMP) or adenosine (cAMP) that play important roles in memory processes are not characterized Alzheimer's disease (AD). The aim this study was to analyse levels these cerebrospinal fluid (CSF) samples from patients diagnosed with clinical and prodromal stages AD expression level enzymes hydrolyzed them [phosphodiesterases (PDEs)] brain vs.For cGMP cAMP CSF analysis, cohort (n = 79) included cognitively normal participants...
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca 2+ influx buffering in early ALS‐affected neurones. This study proposes the modulation of ryanodine receptors (RyRs), key mediators intracellular , as therapeutic target. Experimental Approach A novel class FKBP12 ligands that show activity cytosolic calcium...
In spite of the fact that cholesterol does not pass blood-brain barrier, hypercholesterolemia has been linked to increase Alzheimer's disease (AD) risk. Hypertension is another risk factor and angiotensin converting enzyme (ACE) activity known be increased in AD. Furthermore, a lower incidence AD reported patients taking anti-hypertensive drugs. Here we show levels angiotensinogen (AGT) ACE are cerebrospinal fluid (CSF) with mild cognitive impairment Moreover, CSF positively correlated both...
Summary Several studies support the relation between leptin and Alzheimer's disease ( AD ). We show that levels in CSF are unchanged as subjects progress to . However, hippocampus, signalling was decreased localization shifted, being more abundant reactive astrocytes less neurons. Similar translocation of found brains from Tg2576 apoE4 mice. Moreover, an enhancement receptors hippocampus young mice primary neurons treated with Aβ 1‐42 In contrast, old showed levels. findings those seen were...
Abstract The involvement of the cholinergic system in learning and memory together with cognitive enhancing properties 5‐HT 6 receptor antagonists led us to study relationship between receptors neurotransmission. A selective lesion, induced by injection immunotoxin 192‐IgG‐Saporin into nucleus basalis magnocellularis, failed alter density mRNA or protein expression deafferentated frontal cortex, suggesting that are not located on neurons. antagonist SB‐357134 (0.001–1 µ m ) a...
Growing evidence strongly suggests that high fat diet (HFD) has an important role in some neurodegenerative disorders, including Alzheimer's disease (AD). To identify new cellular pathways linking hypercholesterolemia and neurodegeneration, we analyzed the effects of HFD on gene expression mouse brain. Using cDNA microarrays real time RT-PCR, found a mild, but significant effect several genes. The altered genes include molecules linked to AD pathology others potential interest for...
The present work investigated the involvement of cortisol and its receptors, glucocorticoid receptor (GR) mineralocorticoid (MR), in Alzheimer's disease (AD). Cortisol was measured cerebrospinal fluid (CSF) samples from controls, mild
Previous studies have failed to reach consensus on insulin levels in cerebrospinal fluid of Alzheimer's disease (AD) patients and its relation pathological features. We performed a new analysis at different stages AD, investi
Abstract Chiral micellar electrokinetic chromatography with laser‐induced fluorescence detection (chiral‐MEKC‐LIF) was used to investigate D ‐ and L ‐amino acid contents in cerebrospinal fluid (CSF) samples related different Alzheimer disease (AD) stages. CSF were taken from (i) control subjects (S1 pool), (ii) showing a mild cognitive impairment who remained stable (S2 (iii) an that progressed AD (S3 pool) (iv) diagnosed (S4 pool). The optimized procedure only needed 10 μL of it included...
Inflammation plays an important role in Alzheimer's disease (AD) and other neurodegenerative disorders. Although chronic inflammation later stages of AD is well described, little known about the inflammatory processes preclinical or early prior to plaque deposition. In this study, we report that mediator S100A8 increased with aging mouse brain. It observed as extracellular aggregates, which do not correspond corpora amylacea. aggregation enhanced hippocampi two different models for amyloid-β...
Background and purpose: The beneficial effect of 5‐HT 6 receptor antagonism in cognition remains controversial. This study has been undertaken to reassess the enhancing properties acute vs subchronic treatment with selective antagonist SB‐271046 unimpaired rats, as well against scopolamine (cholinergic‐) or MK‐801 (glutamatergic‐mediated) deficits. Experimental approach: Morris water maze was used, measuring behaviour acquisition retention, swim speed. Other behavioural measures included...
The transgenic Tg2576 mouse is a widely used animal model that develops some of the cognitive and neuropathological deteriorations observed in patients suffering Alzheimer's disease. authors investigated 9-month-old mice with respect to behavioral endocrinological (hypothalamic- pituitary-adrenal [HPA] axis activity) parameters. locomotor activity test revealed moved almost twice as much controls. spent significantly more time visiting open arms performed entries into these than did However,...
Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms trigger synaptic changes memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce impairments different behavioral tasks. However, underlying cholinergic-induced formation remain unclear. The role hippocampal cholinergic denervation on consolidation further acquisition spatial...