A5101845820- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Food composition and properties
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Ocular Diseases and Behçet’s Syndrome
- Peroxisome Proliferator-Activated Receptors
- Microencapsulation and Drying Processes
- Medical Image Segmentation Techniques
- Food Chemistry and Fat Analysis
- Natural Antidiabetic Agents Studies
- AI in cancer detection
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Proteins in Food Systems
- Retinal and Optic Conditions
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Surgical Sutures and Adhesives
Wenzhou Medical University
2016-2025
Affiliated Eye Hospital of Wenzhou Medical College
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2023
University of Pittsburgh
2023
Creative Commons
2023
University of South China
2022
Ministry of Agriculture and Rural Affairs
2020-2021
Shandong Academy of Agricultural Sciences
2020-2021
Qingdao Agricultural University
2019-2020
Shandong University of Finance and Economics
2020
Abstract Ocular injuries and their complications represent the most common causes of visual impairment. For ocular surgery, there is an unmet need for highly transparent bioadhesives with superior adhesion, biocompatibility, regenerative properties. Herein, a novel high‐transparent bioadhesive hydrogel composed gelatin methacryloyl (GelMA) dopamine methacrylamide (DMA) developed by in situ oxidative free‐radical polymerization. This overcomes fundamental weakness mussel‐inspired adhesive...
To assess the incidence, cause and risk factors for unplanned readmission within 90 days after deep anterior lamellar keratoplasty (DALK). A multicentre cross-sectional study of 3603 eyes 3588 patients between January 1st, 2019, September 30th, 2021 in 16 hospitals across China was performed. The demographic clinical features DALK with 90-day those who did not have been compared. were identified by a multivariable Cox regression model. Among 873 (878 eyes) DALK, primary indications keratitis...
Automatic and accurate semantic segmentation of pathological structures in medical images is challenging because noisy disturbance, deformable shapes pathology, low contrast between soft tissues. Classical superpixel-based classification algorithms suffer from edge leakage due to complexity heterogeneity inherent images. Therefore, we propose a deep U-Net with superpixel region merging processing incorporated for enhancement facilitate optimize segmentation. Our approach combines three...
Acanthamoeba keratitis (AK) is an intractable infection of the cornea. Penetrating keratoplasty widely used for management severe AK but suffers from complications like graft rejection, endophthalmitis, and glaucoma. Herein, we aimed to describe surgical technique results elliptical deep anterior lamellar (eDALK) AK. In this retrospective case series, records consecutive patients with poorly responsive medical treatment who underwent eDALK January 2012 May 2020 were reviewed. The largest...
Purpose: To report the indications, surgical techniques, and outcomes of repeat keratoplasty evaluate risk factors for graft failure in Chinese population. Methods: The medical records 216 patients (243 cases) who underwent at least two keratoplasties a leading eye hospital southern China between 2011 2020 were retrospectively reviewed. Indications procedures corneal transplantation analyzed. Kaplan–Meier survival analysis was used to determine rate after keratoplasty. A multivariable model...
To evaluate the long-term outcomes of deep anterior lamellar keratoplasty for management stromal corneal opacities after herpes simplex keratitis (HSK) infection.Case records patients who underwent between January 2006 and June 2012 to treat HSK-related scars were retrospectively analyzed. The cases divided into folds-on, folds-off, no-folds groups based on presence folds intraoperatively. main outcome measures best-corrected visual acuity, endothelial cell density, complications.A total 89...
Purpose: To determine the factors associated with formation of different types big bubble (BB) during DALK.Methods: In this retrospective study, 322 consecutive eyes 307 patients corneal stromal disorders who underwent DALK between January 2014 and June 2017 were included. Age, sex, pathology, visual acuity, curvature, thickness, adverse events recorded. The main outcome measure was success BB respect to pathology.Results: Type-1 achieved in 147 (45.7%), whereas type-2 formed 109 (33.9%)....
Abstract Purpose To evaluate the effects of deep anterior lamellar keratoplasty (DALK) with cross‐linked acellular porcine corneal stroma (APCS) and post‐operative topical tacrolimus treatment in patients fungal keratitis. Methods This multicenter prospective study involved 25 cases keratitis that were treated by DALK APCSs from December 2013 to November 2014 at Wenzhou Eye Hospital Henan provincial Hospital. Signs inflammation, reepithelialization, neovascularization, graft rejection...
To reveal the effects of Oldenlandia diffusa (OD) on relieving progression and development gestational diabetes mellitus (GDM), explore underlying mechanism. A rat model GDM was established by streptozotocin injection. The OD rats were evaluated measuring levels fasting blood glucose (FBG), insulin, hemoglobin A1c (HbA1c), exposing to oral tolerance test (OGTT) histological evaluation pancreas. insulin inflammation response-related factors (tumor necrosis factor [TNF]-α, Interleukin [IL]-6...
Our study aimed to detect the effects of polyphyllin I (PPI) on relieving gestational diabetes mellitus (GDM), and possible mechanism. A mouse model GDM was constructed. The PPI mice were evaluated by detecting blood glucose, insulin level, glucose tolerance test, test. inflammation response in GDM+PPI group enzyme-linked immunosorbent assay (ELISA). effect offspring analyzed. In addition, immunoblot assays performed investigate AMPK pathway. We found that improved diabetes-related symptoms...
Purpose: To report the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed in iridocorneal (ICE) syndrome patients using intraocular lens injector (injector), comparison with those Busin glide. Methods: In this retrospective, interventional comparative study, we evaluated DSAEK (n = 12) or glide for ICE syndrome. Their graft position and postoperative complications were recorded. best-corrected visual acuity (BCVA) cell loss (ECL) monitored over a 12-month...
Resistant starch (RS) has significant effects on patients with type 2 diabetes (T2DM), but there are no published studies of its effect persons at risk for T2DM. Randomized controlled trials were searched using the PubMed, Embase, and Cochrane Library databases. This meta-analysis compared regulatory RS placebo dietary interventions fasting plasma glucose (FPG), insulin (FIN), resistance (HOMA-IR), glycosylated hemoglobin (HbA1c) in diagnosed T2DM those risk. Of 1,144 retrieved, 15 met...
Purpose: The purpose of this study was to report the characteristics new-onset endotheliitis after cataract surgery and identify contributing risk factors. Methods: In single-center study, we retrospectively reviewed clinical records all patients who underwent uneventful in Eye Hospital Wenzhou Medical University between January 2015 December 2016. Postoperative cases were identified by screening keywords individually verified a cornea specialist. Endotheliitis rates 95% confidence intervals...
To investigate the effect of montelukast sodium (singulair) combined with ketotifen fumarate on acute exacerbation chronic obstructive pulmonary disease (AECOPD) airway hyperresponsiveness (AHR) and its helper T cells 17 (Th17)/regulator (Treg).168 patients AECOPD AHR diagnosed in our hospital from February 2018 to December 2019 were selected, divided into observation group (n = 84) control 84). Both groups given anti infection, bronchodilator, glucocorticoid, phosphodiesterase inhibitor,...
Abstract Purpose: To report the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed in iridocorneal (ICE) syndrome patients using intraocular lens injector (injector), which was compared with those Busin glide. Methods: In this retrospective, case-control study, we evaluated DSAEK (n=7) or glide for ICE syndrome. Graft position and postoperative complications were recorded. Best-corrected visual acuity (BCVA) cell loss (ECL) monitored over a 12-month follow-up...