A5050592216- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Skin Diseases and Diabetes
- Psoriasis: Treatment and Pathogenesis
- Dermatological and Skeletal Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Contact Dermatitis and Allergies
- Cellular Mechanics and Interactions
- Cancer Diagnosis and Treatment
- Genetic and rare skin diseases.
- Inflammatory Myopathies and Dermatomyositis
- Drug-Induced Adverse Reactions
- Hair Growth and Disorders
- RNA regulation and disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Medicine, History, and Philosophy
- Poxvirus research and outbreaks
- Dermatologic Treatments and Research
- Nonmelanoma Skin Cancer Studies
- Eosinophilic Disorders and Syndromes
- Tattoo and Body Piercing Complications
University of Jordan
2018-2025
Jordan Hospital
2018
Guy's and St Thomas' NHS Foundation Trust
2010-2013
St. John's University
2012
King's College London
2008-2011
St Thomas' Hospital
2010
University College London
2010
St. John's School
2010
University of London
2010
King's College - North Carolina
2010
Autosomal dominant and recessive forms of dystrophic epidermolysis bullosa (DEB) result from mutations in the type VII collagen gene (COL7A1). Although paradigms have emerged for genotype/phenotype correlation DEB, some pathogenic COL7A1, notably glycine substitutions within triple helix, may lead to diagnostic difficulties, since certain can either or mutant alleles. Delineation substitution into two discrete groups, however, is made difficult by observations that, particular collagen, same...
To translate the topical corticosteroid phobia (TOPICOP) scale into Arabic and assess its validity, reliability, feasibility. A cross-sectional study was carried out at Jordan University Hospital, Amman, Jordan, in 2 phases. Phase one involved translation of TOPICOP using a 2-step process, followed by pilot testing content validation 6 bilingual dermatologists. subsequent feasibility on larger sample 145 participants. administered twice for test-retest analysis. Calculated validity indices...
Abstract Body Dysmorphic Disorder (BDD) is an underexplored psychiatric condition in Middle Eastern countries, particularly patients with dermatologic concerns, where alterations appearance may elevate the risk of BDD. We studied at Jordan University Hospital's general dermatology and cosmetic clinics from July to September 2022, comparing them healthy controls. Patients conditions were evaluated per International Classification Diseases (ICD-10) criteria by trained dermatologists. All...
Epidermolysis bullosa (EB) pruriginosa is an unusual variant of dystrophic EB in which intense itching can lead to striking skin changes resembling acquired disorders such as nodular prurigo or hypertrophic lichen planus. The molecular pathology involves mutations the COL7A1 gene, but nature similar those seen other non-pruritic forms EB. mechanism dramatic phenotypic differences currently unknown. In this study we assessed incidence a common functional polymor-phism matrix...
Please cite this paper as: The molecular skin pathology of familial primary localized cutaneous amyloidosis. Experimental Dermatology 2010; 19: 416–423. Abstract: Familial amyloidosis (FPLCA) is an autosomal dominant disorder associated with chronic itching and lichenification. In lesional skin, there are apoptotic basal keratinocytes deposits amyloid material on degenerate keratin filaments in the upper dermis. genetic basis FPLCA involves mutations OSMR IL31RA genes but disease...
Skin cancers are among the commonest worldwide, and incidence of melanoma non-melanoma skin cancer (NMSC) continues to rise worldwide. However, there no comprehensive reports on in Jordan during past two decades. This report investigates Jordan, particular their time trends for period 2000-2016.Data malignant melanomas (MMs), squamous cells carcinomas (SCCs), basal cell (BCCs) were extracted from Cancer Registry between 2000 2016. Age-specific overall age-standardized rates (ASIRs)...
Epidermolysis bullosa (EB) encompasses a heterogeneous group of inherited skin disorders associated with trauma-induced blistering. The junctional forms EB (JEB), Herlitz JEB, non-Herlitz JEB and pyloric atresia have all been attributed to autosomal recessive inheritance. We describe 7-year-old girl defective dental enamel, blistering subsequent scarring. Her mother, carrier the mutation p.G627V in collagen XVII gene (COL17A1) had evidence hypoplastic enamel without grandmother as result...
This case report describes two severe antiretroviral drug adverse reactions that occurred in the same patient. A 55-year-old HIV-positive African woman received a single epidural triamcinolone injection for pain relief of postherpetic neuralgia. Forty-one days later, she developed iatrogenic Cushing’s syndrome due to drug–drug interaction between and her boosted protease inhibitor therapy. The patient’s regimen was thus changed replace with integrase raltegravir. Shortly after commencing...
Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by sudden onset of pruritic and erythematous macules, urticarial papules, plaques that may coalesce to form reticulated pattern. Lesions typically heal within weeks leaving mottled postinflammatory hyperpigmentation. The majority reported cases originate from Japan with much fewer described worldwide without predominant ethnicity. histopathological features prurigo can be nonspecific; however, distinct exist for...
Journal Article The relevance of patch testing in peristomal dermatitis Get access F. Al‐Niaimi, Al‐Niaimi Department Dermatology, Salford Royal Foundation Trust, Manchester, U.K Firas Al‐Niaimi. E‐mail: firas55@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar M. Beck, Beck N. Almaani, Almaani St John’s Institute London, V. Samarasinghe, Samarasinghe J. Williams, Williams C. Lyon York Hospital, York, British Volume 167, Issue 1, 1 July 2012, Pages 103–109,...
Summary Erythema gyratum repens (EGR) is a rare cutaneous eruption characterized by serpiginous morphology and migrating scaly border. It one of the most specific paraneoplastic phenomena, associated with malignancy in cases. We report 46-year-old Afro-Caribbean man unequivocal clinical histological features pityriasis rubra pilaris (PRP). However, despite improvement on oral acitretin, evolved into striking rash EGR. The histology findings, although nonspecific, were keeping diagnosis No...
Conflict of interest: none declared. A 39‐year‐old man was referred in August 2007 with a 6‐month history an asymptomatic, widespread rash that had appeared 3 days after starting prophylactic azithromycin for Mycobacterium avium intracellulare. He been diagnosed human immunodeficiency virus (HIV) type 1 1994, and at the time presentation he on highly active antiretroviral treatment (HAART) tenofovir/emtricitabene (Truvada®; Gilead Sciences Ltd, Cambridge, UK) lopinavir/ritonavir (Kaletra®;...
Epidermolysis bullosa pruriginosa (EBP) is a clinical variant of dominant or occasionally recessive, dystrophic epidermolysis (EB). Clinically, intense pruritus on background inherited skin fragility often leads to signs that resemble acquired inflammatory disorders such as hypertrophic lichen planus (LP) nodular prurigo. Moreover, symptoms and may not appear until adult life, further compounding difficulties in distinguishing between pathology. We describe 61-year-old white British woman...
The morphologic changes in early-stage mycosis fungoides (MF) might overlap with benign inflammatory dermatitis (BID). Previous studies have described altered expression patterns of several proteins MF, but their diagnostic significance is uncertain. This study aims at examining the frequency CD45RO, NFkB-p105/p50, JAK3, TOX, and IL-17 by immunohistochemistry. cohorts included 21 patients MF 19 BID as a control group. CD45RO was positive all BID. NFkB-p105/p50 showed normal cytoplasmic...
A 56-year-old man with lifelong trauma-induced blisters, nail dystrophy and dental enamel hypoplasia presented a new spontaneous blistering eruption. Clinicopathologically, he had evidence of both an inherited acquired disorder: non-Herlitz junctional epidermolysis bullosa (nHJEB) bullous pemphigoid (BP). HIstological examination skin biopsy found reduced (but not absent) collagen XVII in nonlesional skin, vivo bound anticollagen antibodies perilesional prominent eosinophils lesional...
7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK