A5010708576- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Magnetism in coordination complexes
- Supramolecular Self-Assembly in Materials
- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Polydiacetylene-based materials and applications
- Metal complexes synthesis and properties
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Organic and Molecular Conductors Research
- Proteoglycans and glycosaminoglycans research
- Covalent Organic Framework Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Peptidase Inhibition and Analysis
- Hydrogels: synthesis, properties, applications
- Cancer therapeutics and mechanisms
- Nanocluster Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Metalloenzymes and iron-sulfur proteins
- Bioactive Compounds and Antitumor Agents
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Polymer composites and self-healing
- Silk-based biomaterials and applications
Indian Institute of Science Education and Research, Bhopal
2019-2025
Bhopal Memorial Hospital & Research Centre
2020
Indian Institute of Science Education and Research Berhampur
2020
In this research article, two multicopper [Cu3] and [Cu6] clusters, [Cu3(cpdp)(μ3-SO4)(Cl)(H2O)2]·3H2O (1) [Cu6(cpdp)2(μ2-O)(Cl)2(H2O)4]·2Cl (2) (H3cpdp = N,N′-bis[2-carboxybenzomethyl]-N,N′-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol), have been explored as potent antibacterial antibiofilm agents. Their molecular structures determined by a single-crystal X-ray diffraction study, the compositions established thermal elemental analyses, including electrospray ionization mass spectrometry....
Spin crossover (SCO) in metal-organic cages (MOCs) remains underexplored despite their potential for fascinating applications molecular switches and sensors. The interplay between the structural flexibility of MOCs spin state switching offers a promising avenue tuning magnetic properties controlled environment. Herein, we report how varying diastereomeric ratios, influenced by magnetically inequivalent protons, alter ligand field strength result distinct SCO profiles. Three FeII4L6...
Inflammations are innate and adaptive immune responses, that get instigated in reciprocation to infection. However, when allowed continue unchecked, poses a formidable challenge clinical settings. In search of...
Spin crossover (SCO) in metal‐organic cages (MOCs) remains underexplored despite their potential for fascinating applications molecular switches and sensors. The interplay between the structural flexibility of MOCs spin state switching offers a promising avenue tuning magnetic properties controlled environment. Herein, we report how varying diastereomeric ratios, influenced by magnetically inequivalent protons, alter ligand field strength result distinct SCO profiles. Three FeII4L6...
A two-dimensional coordination polymer [Co(pyz)(CA)]n (complex 1) was synthesized and structurally characterized. Solid-state dc magnetic susceptibility revealed overall antiferromagnetic interactions in the complex with an ordering below 7 K...
In this perspective, cluster-based molecular systems in which composition can be compared with electrocatalytic activity remain under-explored primarily because of the synthetic challenges. Thus, exploring novel electrocatalysts for water splitting...
Spin crossover (SCO) in metal-organic cages (MOCs) remains underexplored despite their potential for fascinating applications molecular switches and sensors. The interplay between the structural flexibility of MOCs spin state switching offers a promising avenue tuning magnetic properties controlled environment. Herein, we report how varying diastereomeric ratios, influenced by magnetically inequivalent protons, alter ligand field strength result distinct SCO profiles. Three FeII4L6...
Studies of proton conductivity in crystalline porous materials (CPMs), mainly metal–organic frameworks (MOFs) and coordination polymers (CPs), have received enormous attention due to their potential application fuel cell membranes. These well-defined structural features, easy synthetic routes, functionalizable channels. factors provide an added advantage targeted synthesis control framework–carrier interactions that eventually determine the orderly arrangement, mobility, density carriers....
The wound recovery phenomenon remains as one of the long challenging concerns worldwide. In search user-friendly dressing materials, in this report, we fabricated a rational combinatorial strategy utilizing stereogenic harmony triphenylalanine fragment and appending it to δ-amino valeric acid at N-terminus (hydrogelators
Deciphering the most promising strategy for evolution of microbial infection and inflammation-based therapeutics is one challenging affairs to date. Development peptide-based smart supergelators with innate antimicrobial anti-inflammatory activities an appealing way out. In this work, hydrogelators Boc-δ-Ava-(X)-Phe-(Y)-Phe-OH (I: X = Y L; II: D; III: IV: D, Ava: δ-amino valeric acid) have been designed fabricated by strategic chiral tuning investigate effect alternation configuration(s) Phe...
Spin–Spin interactions between unpaired electrons in organic radicals are of utter importance from the viewpoint molecular magnetism and development smart materials. The diamagnetic to paramagnetic phase transition observed some often leads "magnetic bistability," sometimes associated with a thermally accessible structural transition. noncovalent determining solid-state packing arrangement highly susceptible external stimuli (temperature, pressure, light, electric field, etc.) allow respond...
A proteolytically stable, biocompatible hydrogel has been developed with a heterochiral diphenylalanine auxin derivative that displayed excellent mechanical integrity & pharmacological properties at room temperature physiological pH.
Herein, three dinuclear iron(II) helicates bearing the molecular formula [Fe2 (L1)3 ](ClO4 )4 ⋅ 2CH3 OH 3H2 O (complex 1), (L2)3 6CH3 CN 2), and (L3)3 0.5H2 3) have been synthesized using imidazole pyridine-imine-based ligands having fluorene moiety in backbone. A change ligand field strength by terminal modulation led to a spin-transition behaviour from incomplete, multi-step complete, around room temperature solid state. Spin transition has also observed solution phase characterized...
Two novel isostructural cyanide-bridged hexadecanuclear complexes with the general formula {[Fe(CN)
Inspired by the prolonged metabolism displayed para substituted fluorinated drugs, we intended to design two isomers Fmoc-(4F)-Phe-Phe-OH (hydrogelator I) & Fmoc-(3F)-Phe-Phe-OH II) explore propensity of fluorine substitution in aromatic ring phenylalanine, assisting or disrupting gelation phenomena. However, our experimental observation reveals that hydrogelator I and II containing fluorines core illustrates excellent hydrogelation ability comparison unsubstituted analogue, accordance with...
The profound effect of chirality in the peptide sequence driving gelation strength, antimicrobial/anti-inflammatory potency, and selectivity is underpinned.
12-Hydroxy stearic acid appended with various aromatic C-terminal residues serves as a new amphiphilic scaffold for selective halide capture.
Abstract Three complexes bearing the molecular formula [Fe(X‐OMe‐SalEen) 2 ]NCY⋅nH O; X=6, Y=S, n=0 ( 1 ); X=5, n=1.5 H O ) and X=4, Y=Se, 3 ), where 6‐OMe‐SalEen=2‐((E)‐(2‐(ethylamino)ethylimino)methyl)‐6‐methoxyphenol, 5‐OMe‐SalEen=2‐((E)‐(2‐(ethylamino)ethylimino)methyl)‐5‐methoxyphenol, 4‐OMe‐SalEen=2‐((E)‐(2‐(ethylamino)ethylimino)methyl)‐4‐methoxyphenol, have been synthesized, characterized their spin crossover behavior has studied. The ligands differ in position of methoxy group...
Abstract Untangling the most selective kinase inhibitors via pharmacological intervention remains one of challenging affairs to date. In accordance this drift, herein we describe design and synthesis a set new heterocyclic analogs consisting 6,7‐dimethyl Quinoxaline, appended connector, employing Schiff base strategy (Compounds I – IX ). The compounds were characterized by various spectroscopic techniques inhibition assay performed on few prime members CMGC family namely GSK3β, DYRK1A CLK1...
Three heterometallic hexanuclear 3d-4f complexes bearing the formula [Cu2 (L)2 Ln4 (L)4 (o-van)2 ] [L=2-((E)-((2-hydroxyphenyl)imino]methyl)phenol; o-van=ortho-vanillin] (LnIII =GdIII (1), DyIII (2), and TbIII (3)) have been synthesized characterized. DC magnetic susceptibility measurements reveal overall antiferromagnetic interactions in 1 3, whereas co-existence of ferro- as well were observed 2. The magnetocaloric effect has for with an entropy change (-ΔSm ) 22.3 J kg-1 K-1 at 3 K 7 T....
The amphiphilic derivatives comprising of non-heterocyclic, hydrophobic amino acids at the C-terminal end, not only displayed excellent gelation ability but also high mechanical integrity in comparison to heterocyclic analogues.
A set of new heterocyclic analogs (Compounds I-IX), comprising 6,7 dimethyl Quinoxalines were found to be active against the receptor GSK3β IV-V) (Chem. Biodiversity 2021, 18, e2100364). In an effort modulate effective CDK5 inhibitors herein our hypothesis underpinned fish out appropriate derivative from same quinoxaline series, as these two targets and shared structural resemblance with each other. Aligned goal we have synthesized Compounds I-IX, characterized them using a combination...