A5090478034- Inflammatory mediators and NSAID effects
- Renal cell carcinoma treatment
- Pain Management and Opioid Use
- Pharmacy and Medical Practices
- Pain Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- Mechatronics Education and Applications
- Schizophrenia research and treatment
- Educational Robotics and Engineering
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Urinary Bladder and Prostate Research
- Advanced Welding Techniques Analysis
- PI3K/AKT/mTOR signaling in cancer
- Tuberous Sclerosis Complex Research
- Pharmaceutical Practices and Patient Outcomes
- Cardiac tumors and thrombi
- Dental Anxiety and Anesthesia Techniques
- Safe Handling of Antineoplastic Drugs
- Cardiac Valve Diseases and Treatments
- Vascular Tumors and Angiosarcomas
- Aortic Thrombus and Embolism
- Teaching and Learning Programming
Kobe University Hospital
2018-2025
Wakayama Medical University
2025
Kobe University
2024
Kobe Pharmaceutical University
2024
Nara Medical University
2023
Yokohama City University Hospital
2020
Yokohama City University
2020
Okayama University
2015-2018
Toyokawa City Hospital
2007
Toin University of Yokohama
2005
We describe the clinical effects of short-term lenvatinib administration prior to conventional transarterial chemoembolization (cTACE) on tumor vasculature. Two patients with unresectable hepatocellular carcinoma underwent high-resolution digital subtraction angiography (DSA) and perfusion four-dimensional computed tomography during hepatic arteriography (4D-CTHA) before after treatment. The doses periods were, respectively, 12 mg/day for 7 days 8 4 days. In both cases, DSA revealed a...
This study aimed to determine the effects of pregnancy and ontogeny on risperidone paliperidone pharmacokinetics by assessing their serum concentrations in two subjects constructing a customized physiologically-based pharmacokinetic (PBPK) model. Risperidone were determined pregnant woman her newborn. PBPK models for adults, pediatric, populations developed verified using Simcyp simulator. These then applied our subjects, generating "virtual twins." Effects both drugs examined with fixed...
Introduction In our previous work, we investigated the analgesic effects of ibuprofen gargle after mandibular third molar extractions. However, a subsequent detailed review individual patient data revealed variations in postoperative pain reduction among patients. Consequently, present study was designed to conduct post-hoc subanalyses that identified factors contributing variation response Materials and methods This involved thirty-five Japanese patients from prior randomized, double-blind,...
Crizotinib, an ATP-competitive receptor tyrosine kinase inhibitor of both anaplastic lymphoma (ALK) and the hepatocyte growth factor receptor, commonly causes several adverse events (AEs). The clinical utility measuring plasma concentration crizotinib in patients with non-small-cell lung cancer (NSCLC) has not been fully elucidated. aim this study was to evaluate variability trough its relationship occurrence AEs NSCLC patients.Plasma samples were collected from 9 ALK fusion gene-positive...
Abstract Objective This study was designed to evaluate the postoperative efficacy and safety of using an ibuprofen gargle as a pain management strategy for patients who have undergone mandibular third molar extraction. We also ensured that quality treatment not compromised throughout study. Material Methods Patients were randomized in 1:1 ratio into two groups: ibuprofen–placebo (IP) group placebo–ibuprofen (PI) group. On Day (POD) 1, IP initiated administration, while PI started taking...
Brexpiprazole is a second-generation antipsychotic approved in Japan 2018; however, information on placental passage and breast milk transfer remains limited. In this report, the patient, 30-year-old pregnant woman with schizophrenia, was medicated brexpiprazole, risperidone, quetiapine.
Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 highly polymorphic. average steady-state plasma concentration of risperidone active moiety higher intermediate metabolizers (IMs) compared with that extensive (EMs). An association between drug-induced extrapyramidal symptoms scale (DIEPSS) score and polymorphisms has not been reported to date. This study investigates severity schizophrenia patients receiving therapy.Schizophrenia undergoing...
Hand-foot skin reaction (HFSR) induced by multiple tyrosine kinase inhibitors (TKIs) is a serious side effect that can cause treatment interruption or decreased dosing. This study was conducted to evaluate the safety and efficacy of bis-glyceryl ascorbate (Amitose bis(di)-glyceryl [DGA])-containing cream (DGA cream) for prevention sunitinib-induced HFSR.A single-arm, open-label phase I/II conducted, targeting patients with metastatic renal cell carcinoma (mRCC) who were receiving sunitinib...
Extraction of mandibular third molars is one the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs associated with adverse events such as gastrointestinal disorders, renal hepatic dysfunction, platelet dysfunction. Topical analgesics have been proposed alternatives to injectable medications safely improve postoperative relief. We will conduct a single-center, placebo-controlled, double-blind,...
Team-based learning (TBL) is an active method which has been designed to help students solve problems both by themselves and as a team. In this study, TBL was introduced in the journal club (gathering read discuss medical papers) for pharmacists, its effectiveness compared with that of traditional lecture. The subjects, 29 pharmacists at Kobe University Hospital, were randomly allocated lecture group group. pre-test conducted two months before club, post-tests immediately one month after...
We have established a collaboration system between community pharmacies and our hospital using the sharing tools of patient information such as tracing reports continuous training sessions by team-based learning method. In this study, we evaluated clinical effectiveness in patients treated with oral anti-cancer drugs adjuvant chemotherapy for gastrointestinal cancers. This retrospective study involved outpatients who started including tegafur-gimeracil-oteracil potassium or capecitabine...
Sunitinib is used as a first-line therapy for metastatic renal cell carcinoma. The primary aim of this study was to determine the optimal total sunitinib (sunitinib plus N-desethyl sunitinib) trough concentration alternative dosing schedule: 2-week-on and 1-week-off schedule (2/1 schedule).Patients with carcinoma treated 2/1 sunitinib, whose concentrations were available, recruited study. Out 19 patients, 17 dosage not changed until measurement drug eligible analysis relationship between...
心臓血管外科専門医制度は現在，新制度への移行の過渡期にある．日本心臓血管外科学会U-40コラムは，前号より専門医制度をテーマとし，第2回目の今号では，心臓血管外科専門医資格取得の現実について取り上げる．アンケート調査を通して，U-40世代の心臓血管外科専門医資格の取得状況や，その過程の詳細を知ることができた．今後専門医資格を取得する予定の若手心臓血管外科医のためにも，現在の問題点と今後の展望について考察する．
We detail an educational program implemented at Toin University of Yokohama in which lab and workshop courses on automated mechanics, from basics to applications, are offered consecutively during the first three undergraduate years. Engineering is a discipline concerned with practical real-world problems, but students rarely have chance gain enough experience effectively understanding engineering. At our department, first- third-year may take several hands-on for fabricating machines –...
Abstract BackgroundExtraction of mandibular third molars is one the most commonly performed oral surgical procedures, and non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral administration NSAIDs produces various adverse events such as gastrointestinal disorders, renal hepatic dysfunction, platelet dysfunction. Topical use analgesics has been proposed an alternative to injectable medications safely improve postoperative relief. We will conduct a...
<sec> <title>BACKGROUND</title> Extraction of mandibular third molars is one the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs associated with adverse events such as gastrointestinal disorders, renal hepatic dysfunction, platelet dysfunction. Topical analgesics have been proposed alternatives to injectable medications safely improve postoperative relief. We will conduct a single-center,...