Healthcare workers (HCWs) are at high risk of COVID-19. However, data on HCWs' knowledge, attitudes, and practices (KAP) toward COVID-19 limited. Between September November 2020, we conducted a questionnaire-based KAP survey among HCWs three hospitals in Uganda. We used Bloom's cut-off ≥80% to determine sufficient good attitude, practice, multivariate Poisson regression with robust variance for statistical analysis. Of 717 invited participate, 657 (91.6%) agreed were enrolled. The mean age...

Abstract Introduction Oral pre‐exposure prophylaxis (PrEP) has been scaled up; however, data from real‐world settings are limited. We studied oral PrEP preference, uptake, adherence and continuation among adolescent girls young women (AGYW) vulnerable to HIV in sub‐Saharan Africa. Methods conducted a prospective cohort study 14‐ 24‐year‐old AGYW without who were followed for 12 months Kampala, Uganda. Within at least 14 days of enrolment, they received two education sessions, including...

Abstract Background We report here on a prospective hospital-based cohort study that investigates predictors of 30-day and 90-day mortality functional disability among Ugandan stroke patients. Methods Between December 2016 March 2019, we enrolled consecutive hemorrhagic ischemic patients at St Francis Hospital Nsambya, Kampala, Uganda. The primary outcome measure was 30 90 days. modified Ranking Scale wasused to assess the level after stroke. Stroke severity admission assessed using National...

Abstract Background: Increased access to ART key populations who bear a disproportionate burden of HIV, including female sex workers, provides great opportunity reduce onward transmission. This is however dependent on achieving high levels adherence ART. We set out determine level and associated factors among workers in Uganda. Methods: In this cross-sectional study between May June 2017, we consecutively enrolled 226 accessing HIV care at an urban clinic Kampala, assessed self-reported...

We assessed the burden and experiences of caregivers looking after stroke patients in Kampala, Uganda.We conducted a qualitative cross-sectional study between May 2018-July 2018 among primary patients.The caregiver was defined as person spending most time providing daily care for patient at least four months. Purposive sampling used to consecutively recruit caregivers. In-depth interviews were conducted, audiotape recorded, observations also made. Data managed using NVIVO 12.0 following...

Background Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 may therefore be a suitable population for vaccine trials. We conducted survey to evaluate willingness-to-participate in trials HCWs three hospitals Uganda. Methods The was between September November 2020. Using standardised questionnaire, data were collected on socio-demographics, previous participation health research, information sources, underlying conditions, Data analysed descriptively binomial...

Background Novel HIV pre-exposure prophylaxis (PrEP) methods including a potential future vaccine, will increase prevention options for adolescent girls and young women (AGYW) at high risk of infection in Eastern Southern Africa, yet data on AGYW’s preferences various PrEP is limited. We investigated five biomedical (oral, injectable, vaginal ring, implant, vaccine) among 14–24-years-old AGYW Kampala, Uganda. Methods From January to December 2019, we conducted mixed study 265 high-risk AGYW....

Adolescent girls and young women (AGYW) account for a disproportionate number of new HIV infections worldwide. prevalence among sex workers in Uganda is 22.5%. Although pre-exposure prophylaxis (PrEP) highly effective biomedical prevention method, awareness PrEP AGYW has not been studied systematically. We aimed to assess factors associated with who frequently reported paid sex.

Background In sub-Saharan Africa, one in every five young women becomes pregnant, and 50% of these are unintended. Pregnancies adolescent girls (AGYW) associated with poorer maternal neonatal outcomes a high abortion rate, yet data still limited on incident pregnancies among AGYW vulnerable situations. We studied the incidence factors unintended pregnancy who were frequently engaged transactional sex Kampala, Uganda. Methods analyzed from study that investigated uptake oral pre-exposure...

Alcohol-related harms may be increased among adolescent girls and young women (AGYW) involved in sex work, yet data on alcohol misuse AGYW sub-Saharan Africa are still scarce. We conducted a cross-sectional study 15–24-year-old from January 2013 to December 2018 Kampala, Uganda used the Alcohol Use Disorder Identification Test (AUDIT) use patterns dependence symptoms (dependence score ≥4). Of 1440 participants (median age 21 years), 83.1% had less than secondary education, 79.8% reported ≥10...

We assessed the prevalence and risk factors associated with virological failure among female sex workers living HIV on antiretroviral therapy (ART) in Kampala, Uganda.We conducted a cross-sectional study between January 2015 December 2016 using routinely collected data at research clinic providing services to women high of STIs including HIV. Plasma samples were tested for viral load from HIV-seropositive aged ≥18 years who had been ART least 6 months received adherence counselling. Samples...

Abstract Background Although cervical cancer is preventable, most women in sub-Saharan Africa (SSA) do not receive routine screening and few treatment options exist. Female Sex Workers (FSWs) are among the Ugandan female population at highest risk of acquiring sexually transmitted infections (STIs) including HIV human papilloma viruses (HPV), cause cancer. We report one-year experiences visual inspection with acetic acid (VIA) positivity FSWs early detection pre-cancerous cancerous lesions...

Data on implementation of ‘Test and Treat’ among key populations in sub-Saharan Africa are still limited. We examined factors associated with prompt antiretroviral therapy/ART (within 1 month HIV-positive diagnosis or week if pregnant) 343 women at high risk for HIV infection Kampala-Uganda, whom 28% initiated ART. Most (95%) reported paid sex within 3 months prior to enrolment. Multivariable logistic regression was used determine baseline characteristics Sex work as main job, younger age...

Although the prevalence of type 2 diabetes mellitus is increasing in Uganda, data on loss to follow up (LTFU) patients care scanty. We aimed estimate proportions LTFU and document associated factors among attending a private not for profit urban clinic Uganda. conducted descriptive retrospective study between March May 2017. reviewed 1818 out-patient medical records adults diagnosed with registered July 2003 September 2016 at St. Francis Hospital - Nsambya Diabetes Data was extracted on:...

Introduction: Family planning (FP) is a key element in the conduct of research and essential managing family sizes. Although fishing communities (FCs) are targeted populations for HIV prevention research, their FP practices poorly understood. We explored barriers facilitators use FCs Lake Victoria Uganda. Methods: employed mixed-methods approach comprising cross-sectional survey, in-depth interviews, focus group discussions 2 FCs. Multivariable logistic regression was used to analyze...

Abstract Background Illicit drug and high-risk alcohol use among adolescents leads to poor health outcomes. We enrolled from urban slums in Kampala, Uganda, assess baseline prevalence factors associated with illicit consumption. Methods conducted a cross-sectional study using data collected cohort that 14-19-year-old male female participants 25 March 2019 30 2020. Data was on social demographics, sexual behavior, reproductive interviewer-administered questionnaires. The main outcomes were...

Abstract Background Immediate uptake of antiretroviral therapy (ART) after an HIV-positive diagnosis (Test and Treat) is now being implemented in Uganda. Data are limited on lost to follow-up (LTFU) high-risk cohorts that have initiated ‘Test Treat’. We describe LTFU a cohort women sexual behaviour who ART under “Test Treat”. Methods performed retrospective study participant records at the Good Health for Women Project (GHWP) clinic, clinic Kampala HIV-infection. included HIV positive ≥18...

Intimate partner violence (IPV) poses a public health burden, yet few studies have assessed co-existence of physical, emotional, and sexual IPV among adolescents. We recent victimization associated factors described patterns perpetrators young people from urban slums in Kampala, Uganda. conducted prospective cohort study 14 to 19-year-old individuals enrolled March 2019 2020 followed quarterly for 12 months. collected data on socio-demographics, behavior, substance use through interviews....

We report the screening and enrollment process for a phase I vaccine trial in Masaka, Uganda that investigated safety immunogenicity of self-amplifying SARS-CoV-2 RNA amongst individuals with without antibodies to SARS-CoV-2. Participant were conducted between December 2021 April 2022. Individuals eligible if they aged 18 45 years, healthy, never vaccinated against COVID-19. antibody status was determined using two point-of-care rapid tests, i.e. Multi G (MGFT3) Standard Q (Standard COVID-19...

Knowledge of family planning (FP) is a key determinant contraceptive use which ultimately plays role in attainment good health and conduct clinical research. People living fishing communities (FCs) have limited access to services including FP are targeted for future research but their knowledge its correlates scantily known. We determined among people FCs L. victoria Uganda inform education programs FCs.We conducted comparative cross-sectional survey participants aged 15-49 years from...

Background In populations at high risk of HIV infection, rates depression can be elevated with far-reaching effects on overall well-being. There is limited research among young women engaged in high-risk sexual behaviour low and middle-income settings. We investigated the prevalence, correlates factors associated mean HSCL score (aged 15–24 years old) Kampala, Uganda. Methods conducted a baseline analysis randomized controlled trial. Probable was measured using 15-item Hopkins Symptoms...

Background: There is limited evidence on the relationship between sustained exposure of female sex workers (FSWs) to targeted HIV programmes and incidence. We investigate number missed study visits (MSVs) within each episode 2 consecutively attended subsequent risk in a predominantly FSW cohort. Methods: Women at high are invited attend an ongoing dedicated clinic offering combination prevention intervention Kampala, Uganda. Study scheduled once every 3 months. The analysis included...