A5088142129- Parkinson's Disease Mechanisms and Treatments
- Microplastics and Plastic Pollution
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Graphene and Nanomaterials Applications
- Mesenchymal stem cell research
- Tryptophan and brain disorders
- Intracranial Aneurysms: Treatment and Complications
- Food composition and properties
- Neurological diseases and metabolism
- Aortic Disease and Treatment Approaches
- Clinical Nutrition and Gastroenterology
- Cardiovascular Health and Disease Prevention
- Peptidase Inhibition and Analysis
- Cardiovascular and Diving-Related Complications
- Lipoproteins and Cardiovascular Health
- Conducting polymers and applications
- Liver Disease Diagnosis and Treatment
- biodegradable polymer synthesis and properties
- Tissue Engineering and Regenerative Medicine
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
Wuhan University
2018-2025
Renmin Hospital of Wuhan University
2018-2025
Qingdao University
2023
Union Hospital
2015-2017
Huazhong University of Science and Technology
2015-2017
Diabetic nephropathy (DN) is a prevalent chronic microvascular complication of diabetes and the leading cause end-stage renal disease (ESRD). Understanding progressive etiology DN critical for development effective health policies interventions. Recent research indicated that polystyrene microplastics (PS-MPs) contaminate our diets accumulate in various organs, including liver, kidneys, muscles.
Abstract In recent years, microplastics (MPs) have gained significant attention as a persistent environmental pollutant resulting from the decomposition of plastics, leading to their accumulation in human body. The liver, particularly individuals with type 2 diabetes mellitus (T2DM), is known be more susceptible adverse effects pollutants. Therefore, investigate potential impact MPs on liver diabetic mice and elucidate underlying toxicological mechanisms, we exposed db/db 0.5 μm for 3...
P2Y12 is a well-recognized receptor expressed on platelets and the target of thienopyridine-type antiplatelet drugs. However, recent evidence suggests that in vessel wall plays role atherogenesis, but mechanisms remain elusive. In this study, we examined molecular how mediates vascular smooth muscle cells (VSMCs) migration promotes progression atherosclerosis.Using high-fat diet-fed apolipoprotein E-deficient mice model, found expression VSMCs increased time-dependent manner had linear...
Depression, one of the most common causes disability, has a high prevalence rate in patients with metabolic syndrome. Type 2 diabetes are at an increased risk for depression. However, molecular mechanism coupling to depressive disorder remains largely unknown. Here we found that neuroinflammation, associated high-fat diet (HFD)-induced and obesity, activated transcription factor CCAAT/enhancer binding protein β (C/EBPβ) hippocampal neurons. This repressed brain-derived neurotrophic (BDNF)...
Abstract The aggregation of α‐synuclein plays a pivotal role in the pathogenesis Parkinson's disease (PD). Epidemiological evidence indicates that high level homocysteine (Hcy) is associated with an increased risk PD. However, molecular mechanisms remain elusive. Here, we report thiolactone (HTL), reactive thioester Hcy, covalently modifies on K80 residue. levels K80Hcy brain are age‐dependent manner TgA53T mice, correlating elevated Hcy and HTL during aging. N‐homocysteinylation stimulates...
Alcohol-associated liver disease is a prevalent chronic caused by excessive ethanol consumption. This study aims to investigate the role of miR-150 in regulating hepatic lipid homeostasis alcoholic fatty (AFL). was mainly distributed nucleus hepatocytes and correlated with degree injury. The decreased expression observed AFL compensatory response ethanol-induced steatosis. Overexpression facilitated accumulation cellulo exacerbated steatosis vivo. In silico analysis identified perilipin-2...
Cerebrotendinous xanthomatosis (CTX), an autosomal recessive disorder characterized by high levels of cholestanol in the blood and accumulation multiple tissues, especially brain, often presents parkinsonism. However, it remains unknown whether plays a role pathogenesis sporadic Parkinson's disease (PD). Here, we show that serum patients with PD are higher than those control participants. Cholestanol activates protease asparagine endopeptidase (AEP) induces fragmentation α-synuclein (α-syn)...
Parkinson's disease (PD) is characterized by the deposition of misfolded α-synuclein (α-syn) in brain. Converging evidence indicates that intracellular transmission and subsequent templated amplification α-syn are involved onset progression PD. However, molecular mechanisms underlying cell-to-cell pathological remain poorly understood. Microglia highly activated brains PD patients. Here, it shown depletion microglia slows spread pathology mice injected with fibrils. phagocytose fibrils...