A5100342861- Psoriasis: Treatment and Pathogenesis
- Obstructive Sleep Apnea Research
- Cardiovascular Disease and Adiposity
- Cardiovascular and Diving-Related Complications
- Acute Ischemic Stroke Management
- Spine and Intervertebral Disc Pathology
- Mesenchymal stem cell research
- Antiplatelet Therapy and Cardiovascular Diseases
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- RNA modifications and cancer
- TGF-β signaling in diseases
- Brain Tumor Detection and Classification
- Regulation of Appetite and Obesity
- Cardiac Fibrosis and Remodeling
- Syphilis Diagnosis and Treatment
- Ocular Infections and Treatments
- Ginseng Biological Effects and Applications
Beijing University of Chinese Medicine
2025
North China Electric Power University
2025
First Hospital of China Medical University
2020-2024
Xian Yang Central Hospital
2022-2024
Tsinghua University
2024
Education Department of Heilongjiang Province
2024
China Medical University
2020-2024
Wuhan Third Hospital
2023-2024
First Affiliated Hospital of Zhengzhou University
2022-2024
Northwestern Polytechnical University
2024
Due to differences in resource endowments, levels of economic development, energy structure, and effects policy implementation, the level clean development different regions China is nonuniform. To achieve carbon peaking neutrality, it necessary clarify law formulate policies tailored local conditions. Based on relevant data power, this paper establishes a system for evaluating each region by entropy method quantitatively analyzes key factors influencing regional development. this,...
Diabetic nephropathy (DN) is a prevalent chronic microvascular complication of diabetes and the leading cause end-stage renal disease (ESRD). Understanding progressive etiology DN critical for development effective health policies interventions. Recent research indicated that polystyrene microplastics (PS-MPs) contaminate our diets accumulate in various organs, including liver, kidneys, muscles.
Since the beginning of Russia–Ukraine war, China and Russia have been considering increasing their natural gas trade as a key energy policy direction, negotiating several grand projects to support strategic cooperation. This research forecasts future scenarios for demand supply in then evaluates potential effects these projects. Results show that by 2030, China's demand, production, imports will reach 655.37, 407.00, 248.37 billion cubic meters (cm), respectively. peak years after 2030. If...
Tyroservatide (YSV), a bioactive tripeptide, holds potential as an anti-tumor agent. However, its specific effects on oral squamous cell carcinoma (OSCC) have not been elucidated. This study aims to investigate the inhibitory of YSV OSCC and explore underlying molecular mechanisms. A series in vitro experiments were conducted assess impact viability, colony formation, cycle, apoptosis. RNA sequencing (RNA-seq), docking, western blotting employed Additionally, subcutaneous tumor model was...
Abstract Background The objective of this study was to determine the independent and incremental values advanced oxidative protein product (AOPP), interleukin 6 (IL-6), growth differentiation factor 15 (GDF15) in identifying arteriosclerosis patients with obstructive sleep apnea (OSA). Methods A total 104 individuals diagnosed OSA by polysomnography were recruited our study. Arteriosclerosis defined measuring ultrafast pulse wave velocity carotid artery. Peripheral venous blood samples...
Abstract In recent years, microplastics (MPs) have gained significant attention as a persistent environmental pollutant resulting from the decomposition of plastics, leading to their accumulation in human body. The liver, particularly individuals with type 2 diabetes mellitus (T2DM), is known be more susceptible adverse effects pollutants. Therefore, investigate potential impact MPs on liver diabetic mice and elucidate underlying toxicological mechanisms, we exposed db/db 0.5 μm for 3...
Toll-like receptor 2 (TLR2) and TLR3 regulate hepatic immunity under pathological conditions, but their functions potential drug targets in alcoholic liver disease (ALD) remain poorly understood.ALD-associated injury were induced TLR2 knockout (TLR2-/-), TLR3-/-, TLR2-/- bone marrow transplanted (BMT), TLR3-/- BMT, IL-10-/- mice, wild-type littermates through ethanol challenge with or without co-administered epigallocatechin-3-gallate (EGCG). Moreover, Kupffer cells depleted by GdCl3...
Psoriasis is a common chronic inflammatory systemic disease. Epidermal proteins are considered to be important in maintaining skin barrier function, innate immunity and inflammation. To define more possible roles of the epidermis pathogenesis psoriasis, quantified proteomic analysis was used screen analyze differentially expressed epidermal between 16 psoriasis patients 15 healthy controls. Upregulated differential expression (DEPs) include several significant functional protein clusters,...
Papillary renal cell carcinoma (PRCC) accounts for 15% of all carcinomas. The molecular mechanisms papillary remain unclear, and treatments advanced disease are limited.We built the computing model as follows: Risk score = 1.806 * TPX2 - 0.355 TXNRD2 0.805 SLC6A20. 3-year AUC overall survival was 0.917 in training set (147 PRCC samples) 0.760 test (142 samples). Based on robust model, M2 macrophages showed positive correlation with risk score, while M1 were opposite. patients low higher...
There are presently no miracle drugs for non-alcoholic fatty liver disease (NAFLD). This study investigates the synergistic effect of Silibinin combined with Pu-erh tea extract (PTE) against NAFLD and explores suggested mechanism action. Ob/ob mice were fed a high fat diet along oral administration (86 mg per kg day), PTE (250 day) or their combination 6 weeks. Their lean littermates who standard chow used as control group. The blood biochemical index histopathological evaluation analyzed....
A novel β-glucosidase gene (Bgl3B) of glycoside hydrolase (GH) family 3 was cloned from the thermophilic fungus Talaromyce leycettanus JM12802 and successfully expressed in Pichia pastoris. The deduced Bgl3B contains 860 amino acid residues with a calculated molecular mass 91.2 kDa. purified recombinant exhibited maximum activities at pH 4.5 65°C remained stable temperatures up to 60°C 3.0-9.0, respectively. enzyme broad substrate specificities, showing β-glucosidase, glucanase, cellobiase,...
Previous studies have indicated that the patients with psychiatric illness were at higher risk of hepatitis B virus (HBV) infection. However, efficacy vaccine in schizophrenia remains unclear.Between June 2014 and January 2015, 415 3,038 controls who had been routinely immunized as infants recruited present study. Hepatitis surface antigen (HBsAg), HBsAb, HBV DNA detected commercial methods according to manufacturer's protocol. A 600-bp region S gene (region nt236-nt835) was amplified by...
THPIC was developed to detect HClO in lysosomes. The results showed that could be used as a biomarker for evaluating drug-induced cardiotoxicity, and applied platform screening drugs prevent cardiotoxicitys.
The objective of this study was to examine the potential induction senescence in vascular endothelial cells (VECs) by chronic intermittent hypoxia (CIH), a defining characteristic obstructive sleep apnea (OSA). This investigation seeks elucidate underlying mechanisms that contribute development cardiovascular diseases patients with OSA, particular focus on CIH-induced aging.
Abstract The orexin system is closely related to the pathogenesis of Alzheimer’s disease (AD). Orexin-A aggravates cognitive dysfunction and increases amyloid β (Aβ) deposition in AD model mice, but studies different dual receptor (OXR) antagonists have shown inconsistent results. Our previous study revealed that OX1R blockade deficits pathological progression 3xTg-AD effects OX2R its potential mechanism not been reported. In present study, was blocked by oral administration selective...