A5010442368- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Neonatal Health and Biochemistry
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Digital Marketing and Social Media
- Renal and related cancers
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Metabolism and Genetic Disorders
- Technology Adoption and User Behaviour
- PI3K/AKT/mTOR signaling in cancer
- Congenital Heart Disease Studies
- Nuclear Receptors and Signaling
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Congenital Anomalies and Fetal Surgery
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related Molecular Pathways
- Drug Transport and Resistance Mechanisms
- Digestive system and related health
University of Illinois Urbana-Champaign
2022-2024
University of Illinois Chicago
2022-2024
Illinois College
2022-2024
International Centre for Genetic Engineering and Biotechnology
2018-2023
University of Alabama at Birmingham
2021-2022
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2018
Department of Biotechnology
2011
All India Institute of Medical Sciences
2011
Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels. However, high concentrations, it produces severe neurological damage and death associated with kernicterus due to oxidative stress other mechanisms. While widely recognized that by different toxic insults results in cellular macromolecules, especially DNA, no data are available either on DNA the brain triggered hyperbilirubinemia during neonatal period or activation of repair Here, using mouse model...
A major challenge of targeting metabolism for cancer therapy is pathway redundancy, in which multiple sources critical nutrients can limit the effectiveness some metabolism-targeted therapies. Here, we analyze lineage-dependent gene expression human breast tumors to identify differences metabolic that may redundancy and create therapeutic vulnerabilities. We find serine synthesis PSAT1 most depleted luminal relative basal tumors. Low prevents de novo biosynthesis sensitizes cells glycine...
The nonphysiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond certain therapeutic agents. Here, we comprehensively evaluated physiological response by performing drug screening human plasma-like medium. We observed dramatic nutrient-dependent changes sensitivity a variety FDA-approved and clinically trialed compounds, rigosertib, an experimental that recently failed phase III clinical...
The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse biosynthetic functions. While some tumors can synthesize de novo, others are auxotrophic and therefore reliant on uptake. Importantly, despite several transporters being known be capable of transporting serine, the that mediate uptake in not known. Here, we characterize transporter ASCT2 (SLC1A5) as major contributor cells. well glutamine cancer, our work demonstrates compete through ASCT2. We...
ObjectivesTo study the origin and spread of chloroquine-resistant Plasmodium falciparum population in Indian subcontinent.
Metabolic reprogramming, due in part to the overexpression of metabolic enzymes, is a key hallmark cancer cells. Lactate dehydrogenase (LDHA), enzyme that catalyzes interconversion lactate and pyruvate, overexpressed wide variety types, including pancreatic ductal adenocarcinoma (PDAC). Furthermore, genetic or pharmacological inhibition LDHA suppresses growth, demonstrating cancer-promoting role for this enzyme. Therefore, several inhibitors are being developed tested as potential...
SUMMARY The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse biosynthetic functions. While some tumors can synthesize de novo , others are auxotrophic and therefore reliant on the uptake of exogenous serine. Importantly, however, transporter(s) that mediate in not known. Here, we characterize transporter ASCT2 (coded by gene SLC1A5 ) as primary cells. well-known glutamine cancer, our work demonstrates compete through ASCT2. We further show...
ABSTRACT The non-physiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond certain therapeutic agents. Here, we comprehensively evaluated physiological impact response by performing drug screening human plasma-like medium (HPLM). We observed dramatic nutrient-dependent changes sensitivity a variety FDA-approved and clinically trialed compounds, rigosertib, an experimental that has...
(AAV)-mediated episomal gene replacement therapy for monogenic liver disorders is currently limited in pediatric settings due to the loss of vector DNA, associated with hepatocyte duplication during growth. Genome editing a promising strategy leading permanent and specific genome modification that transmitted daughter cells upon proliferation. Using targeting, we previously rescued neonatal lethality mice Crigler-Najjar syndrome. This rare disease characterized by severe unconjugated...
Abstract The non-essential amino acid L-serine (serine) plays an important role in cancer cell growth due to its diverse biosynthetic functions. In many cells, serine can be taken up from the circulation or synthesized through synthesis pathway (SSP). We have recently discovered that luminal breast tumors are auxotrophic for lineage-specific silencing of SSP gene PSAT1, rendering cells sensitive deprivation both vitro and vivo. At present only way reduce availability vivo is dietary...
Background: CHD is the most common congenital malformation in live births with an incidence of around 1% general population. The present study was conducted detect heart disease ultrasonography. Materials & Methods: This on 28 cases recorded USG. Antenatal ultrasound examinations were performed between 13 and 26 weeks. Results: Maximum patients gestation age 13-17 weeks (12) followed by 17-21 (10) 21-26 (6). difference non- significant (P> 0.05). Among various disorders atrioventricular...