A5038495032- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Pain Mechanisms and Treatments
- Pregnancy and Medication Impact
- Pneumocystis jirovecii pneumonia detection and treatment
- Herpesvirus Infections and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Adolescent and Pediatric Healthcare
- Prenatal Screening and Diagnostics
- Global Maternal and Child Health
- Disability Education and Employment
- Hepatitis B Virus Studies
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- Parvovirus B19 Infection Studies
- Biological Research and Disease Studies
- Plant-based Medicinal Research
- Pharmacology and Obesity Treatment
- Renal cell carcinoma treatment
- Immune responses and vaccinations
- Surgical Sutures and Adhesives
University of Delaware
2016
National Institutes of Health
1987-2010
Ministry of Public Health
2004-2009
AIDS United
2008-2009
Centers for Disease Control and Prevention
2005-2008
HIV Netherlands Australia Thailand Research Collaboration
2006
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2005-2006
SUNY Upstate Medical University
2003-2004
Boston University
2003
University of California, San Diego
2003
Maternal-infant transmission is the primary means by which young children become infected with human immunodeficiency virus type 1 (HIV). We conducted a randomized, double-blind, placebo-controlled trial of efficacy and safety zidovudine in reducing risk maternal-infant HIV transmission. HIV-infected pregnant women (14 to 34 weeks' gestation) CD4+ T-lymphocyte counts above 200 cells per cubic millimeter who had not received antiretroviral therapy during current pregnancy were enrolled. The...
Connor, Edward M.; Sperling, Rhoda S.; Gelber, Richard; Kiselev, Pavel; Scott, Gwendolyn; O'Sullivan, Mary Jo; VanDyke, Russell; Bey, Mohammed; Shearer, William; Jacobson, Robert L.; Jimenez, Eleanor; O'Neill, Edward; Bazin, Brigitte; Delfraissy, Jean-Francois; Culnane, Mary; Coombs, Robert; Elkins, Moye, Jack; Stratton, Pamela; Balsley, James Author Information
The objective of this review is to report the Clinical Year in Review proceedings field nonsmall cell lung cancer that were presented at 2012 European Respiratory Society Congress Vienna, Austria. Various topics reviewed, including epidemiology, screening, diagnosis, treatment, prognosis, and palliative end life care.
Sixty-four patients were entered into a randomized trial that evaluated intra-arterial (LA.) versus intravenous (I.V.) 5-fluo-rodeoxyuridine (FUDR) for colorectal liver metastases. There was significantly improved response rate LA. (62%) compared with I.V. (17%) treatment (p < 0.003). However, the in whom therapy used did not translate to survival rate. The 2-year actuarial rates groups which and 22% 15% respectively, curves differing = 0.27). These results may have been due inclusion of...
In a double-blind, randomized, crossover study, 58 patients with postherpetic neuralgia received 6-week courses of amitriptyline, 12.5 to 150 mg/d; lorazepam, 0.5 6 or lactose placebo. Doses were titrated the maximum level tolerated. Patients rated pain in diary, using lists verbal descriptors. Forty-seven percent reported moderate greater relief 16% placebo, and 15% lorazepam. Mean amitriptyline dose was 65 mg/d. Greater associated higher doses, up maxiumum mg/d, serum tricyclic levels....
THE SUCcessful perinatal human immunodeficiency virus (HIV) prevention trial, the Pediatric AIDS Clinical Trials Group Protocol 076 (PACTG 076), which included an intensive regimen of zidovudine, were reported in February 1994, use zidovudine for mother-toinfant transmission HIV has become widespread United States. 1,2However, late effects exposure to antiretroviral drugs on subsequent health uninfected children are unknown and can be determined only by long-term follow-up exposed...
In a randomized, double-blind crossover study, 40 patients with postherpetic neuralgia were given single oral doses of clonidine, 0.2 mg, codeine, 120 ibuprofen, 800 or inert placebo. Pain relief and side effects recorded for 6 hours. Patients reported significantly more after clonidine than the other three treatments. Codeine ibuprofen ineffective. Sedation, dizziness, frequent (74%) codeine (69%) placebo (36%) (28%). Reported pain was greater during trials in which present. A single, mild...
Objective: To determine the safety of zidovudine (ZDV) regimen utilized in Pediatric AIDS Clinical Trial Group (ACTG) 076 study. Design: ACTG was a randomized, double-blind, placebo-controlled trial which demonstrated that ZDV could prevent mother-to-child HIV-1 transmission. Infants were followed through 18 months age and women 6 postpartum. Methods: Maternal complications, pregnancy outcomes, growth development uninfected infants, disease progression monitored prospectively. Results:...
Zidovudine (ZDV) therapy during pregnancy and to the neonate reduced perinatal HIV transmission by nearly 70% in Pediatric AIDS Clinical Trials Group (PACTG) protocol 076. ZDV has been reported as positive several vitro carcinogenicity screening tests. We evaluated short-term risk for tumors 727 children with known exposure enrolled into PACTG 076/219 Women Infants Transmission Study (WITS). utero (antepartum) occurred 97% 99% of infants or WITS, respectively. Mean follow-up was 38.3 months...
Objectives. To compare the safety and tolerance of stavudine (d4T) versus zidovudine (ZDV, AZT) in symptomatic human immunodeficiency virus-infected children 3 months to 6 years age. Methods. In an initially double-blind trial, 212 evaluable who had received no more than weeks previous antiretroviral therapy were randomized receive either d4T (1 mg/kg orally every 12 hours, maximum 40 mg hours) or (180 mg/m2 200 hours). The study was unblinded after a median follow-up period 6.3 months; at...
Objective. To determine the concentrations of protease inhibitors in cord blood after prenatal inhibitor use by pregnant women. Design. Retrospective analysis samples collected a clinical trial. Methods. Protease were measured from women enrolling PACTG 316 study who receiving antiretroviral therapy. Results. In 68 treated with during pregnancy, concentration these drugs was below assay lower limit detection most samples, including all indinavir (n = 21) and saquinavir 8), 5 6 (83%)...
To determine rate of and risk factors for birth defects in infants born to HIV-infected women receiving nucleoside protease inhibitor antiretroviral (ARV) therapy.
Each year in Thailand, about 10,000 children are born at risk for mother-to-child human immunodeficiency virus (HIV) transmission. In 2000, Thailand implemented a national program to prevent HIV transmission.To describe the results of implementation program.Monthly collection summary data from hospitals.Public health hospitals (n = 822) all 12 regions representing 75 provinces, excluding Bangkok.Women giving birth October 2000 through September 2001, including HIV-seropositive women and...
Objective: To evaluate cord blood and predose nevirapine concentrations in infants exposed to the two-dose intrapartum neonatal regimen. Methods: The authors obtained plasma samples for assay from just prior 48-hours 72-hours after birth dose a subset of participating PACTG 316, randomized, placebo-controlled trial regimen added standard antiretroviral therapy. Results: Nevirapine were measured 109 149 samples. Cord below target concentration 100 ng/mL (10-times vitro IC50 against wild-type...
We have documented functional and psychosocial changes in patients with extremity soft tissue sarcomas who undergone multimodality limb-sparing treatments. In 88 patients, parameters related to economic status, sexual activity, pain, limb function, global quality of life (QOL) were recorded prior surgery every 6 months postoperatively. Changes from the preoperative assessment for parameter analyzed each patient. Six after surgery, there was a decrease employment function significant number...
Prolonged coinfection with GB virus C (GBV-C) has been associated improved survival in human immunodeficiency (HIV)-infected adults. We investigated whether maternal or infant GBV-C infection was mother-to-child transmission (MTCT) of HIV-1 infection.The study population included 1364 HIV-infected pregnant women enrolled 3 studies MTCT HIV Bangkok, Thailand (the were conducted from 1992-1994, 1996-1997, and 1999-2004, respectively). tested plasma collected at delivery for RNA, antibody,...
The pharmacokinetics, safety, tolerance, and antiviral effects of ganciclovir (Gcv) administered orally were evaluated in 36 children infected with cytomegalovirus (CMV) who severely immunocompromised by infection human immunodeficiency virus type 1. In this dose-escalation study, 30 mg/kg Gcv every 8 h produced serum levels similar to the dose (1 g/8 h) effective for maintenance treatment CMV retinitis adults. older children, concentrations after administration capsules suspension. All...
In 2000, Thailand implemented a national program to prevent mother-to-child HIV transmission (PMTCT).To describe the effectiveness of prevention in Thailand.A register HIV-exposed children at birth was created with follow-up infection status. The included born HIV-infected women between 1 January 2001 and 31 December 2003 84 public health hospitals six provinces Thailand. main outcome measure children.A total 2200 mothers were registered. Of these mother-infant pairs, 2105 (95.7%) received...
Human immunodeficiency virus (HIV)-infected women are at increased risk for developing cervical cancer and infection with human papillomavirus (HPV). Prophylactic vaccines targeting HPV types 16 18 being evaluated efficacy among young women.The goal was to assess the prevalence of HIV-infected pregnant in Bangkok evaluate need prophylactic studies this population.The study population consisted 256 who participated a mother-to-child HIV transmission trial. Stored cervicovaginal lavage samples...
Objectives. To evaluate the pharmacokinetic features, safety, and tolerance of abacavir, given alone in combination with other nucleoside antiretroviral agents, symptomatic human immunodeficiency virus (HIV)-infected children. Methods. HIV-infected children discontinued prior therapy were abacavir orally, 4 mg/kg every 12 hours for 6 weeks, followed by 8 weeks (n = 39); or 8). Children then randomized to receive a second agent (zidovudine, stavudine, didanosine, lamivudine), plus abacavir....
Prognostic indicators in 67 patients with unresectable colorectal liver metastases were analyzed. These identified to have isolated hepatic after extensive radiological evaluation and demonstrated good performance status without evidence of failure. Univariate analysis revealed 6 22 factors that associated survival: alkaline phosphatase (AP), lactic dehydrogenase (LDH), occult intra-abdominal extrahepatic disease, percent replacement by tumor (PHR), sex, carcinoembryonic antigen (CEA). A...
Abstract College programs for students with intellectual disability frequently engage peer mentors to promote students' social connections on campus. The qualitative study discussed in this article was conducted explore, from mentors' perspectives, how mentor/mentee relationships developed, offered supports, and facilitated membership into the campus community. Using Pawson's (2004) conceptual framework, mentoring were analyzed regard status, reference group, mechanisms. Mentors perceived...