A5076724943- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cancer survivorship and care
- Nutrition and Health in Aging
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Pneumonia and Respiratory Infections
- Prostate Cancer Diagnosis and Treatment
- Medication Adherence and Compliance
- Ethics in Clinical Research
- Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Heart Failure Treatment and Management
- Exercise and Physiological Responses
- Antimicrobial Resistance in Staphylococcus
- Lung Cancer Research Studies
- Antibiotic Use and Resistance
- Head and Neck Cancer Studies
- Economic and Financial Impacts of Cancer
- Dietary Effects on Health
- Air Quality and Health Impacts
- Balance, Gait, and Falls Prevention
Thomas Jefferson University
2022-2025
Sidney Kimmel Comprehensive Cancer Center
2024-2025
Sidney Kimmel Cancer Center
2021-2024
Thomas Jefferson University Hospital
2023-2024
University at Buffalo, State University of New York
2016-2023
Roswell Park Comprehensive Cancer Center
2021
National Institute of Allergy and Infectious Diseases
2000
To examine the prevalence of potentially inappropriate medication (PIM) prescribing and its association with healthcare utilization related expenditures utilizing nationally representative data from United States.Retrospective cohort study.The 2011-2015 Medical Expenditure Panel Survey (MEPS).Community-dwelling sample U.S. adults aged 65 older during first round each MEPS cycle.A qualified definition operationalized 2019 American Geriatrics Society Beers Criteria® was used to estimate PIM...
Acute respiratory tract infections (ARIs) are common in the outpatient setting. Although they predominantly viral, antibiotics often prescribed for treatment of ARIs. Using U.S. Medical Expenditure Panel Survey (MEPS; 2010–2015), we estimated national prevalence and predictors antibiotic prescribing ARIs by provider type. We categorized trends prescriptions (overall or broad-spectrum) type (physician advanced practice [APP] which includes nurse practitioner [NP], physician assistant [PA])....
Abstract Breast cancer affects over 300, 000 individuals annually in the United States, with survival rates improving due to advances chemotherapy, radiation, hormonal, and targeted therapies. However, these treatments may inadvertently accelerate biological aging through epigenetic modifications, including DNA methylation, histone alterations, changes non-coding RNAs. This review explores how breast therapies impact aging-related pathways. Chemotherapy induces cellular senescence by...
Abstract Background: While ICIs have revolutionized NSCLC management, studies regarding real-world ICI uptake are limited. Before became the standard of care, research uncovered inequities in treatment outcomes by race and other social determinants, like rurality. It is unclear if similar disparities exist for treatment. This population-based study aims to investigate differences rurality among late-stage patients. Methods: Patients ≥ 66 years diagnosed with stage III or IV NSCLC, continuous...
Previous studies have demonstrated increasing mortality due to falls among older adults. The objective of this study was determine whether there an increase in fall risk drug prescribing and if is concurrent with fall-related persons 65 years the United States.
The pharmacokinetics, safety, tolerance, and antiviral effects of ganciclovir (Gcv) administered orally were evaluated in 36 children infected with cytomegalovirus (CMV) who severely immunocompromised by infection human immunodeficiency virus type 1. In this dose-escalation study, 30 mg/kg Gcv every 8 h produced serum levels similar to the dose (1 g/8 h) effective for maintenance treatment CMV retinitis adults. older children, concentrations after administration capsules suspension. All...
Abstract Outpatient parenteral antimicrobial therapy (OPAT) programmes facilitate hospital discharge, but patients remain at risk of complications and consequent healthcare utilisation (HCU). Here we elucidated the incidence factors associated with HCU in OPAT patients. This was a retrospective, single-centre, case–control study adult discharged on OPAT. Cases ( n = 63) controls 126) were that did or not utilise system within 60 days. Characteristics bivariate analysis P ≤ 0.2) included...
Abstract Background While often life-saving, treatment for head and neck cancer (HNC) can be debilitating resulting in unplanned hospitalization. Hospitalizations patients may disrupt result poor outcomes. Pre-treatment muscle quality quantity ascertained through diagnostic imaging help identify at high risk of outcomes early. The primary objective this study was to determine if pre-treatment musculature associated with all-cause mortality. Methods Patient demographic clinical...
Pharmacists in primary care settings have unique opportunities to address the causes of ineffective transitions. The objective this study is describe implementation a multifaceted pharmacist transitions (TOC) intervention integrated into practice and evaluate effectiveness program. This was two-phase pilot describing development, testing, evaluation TOC In Phase 1, implemented general patient population, while 2 focused on high-risk patients. two phases were compared each other (Phase 1 vs....
Cancer patients are at risk for malnutrition; the aim of this study was to provide a cost-effectiveness analysis dietary supplementation in cancer survivors. We estimated prevalence supplementation, hospitalization rates, quality life (QOL), cost care and mortality among built decision analytic model simulate life-long costs health QOL survivors with without supplementation. Cost supplements derived from national pharmacy databases including single- multivitamin formularies. One-way...
Head and neck cancer (HNC) treatment-related morbidity can be detrimental to quality of life (QOL). Myosteatosis is associated with poor QOL in multiple cancers. If predictive trajectories, myosteatosis would a tool for clinicians determine which patients may require additional support during treatment. The purpose this study was if pretreatment trajectory following treatment completion. Methods: In retrospective cohort design, determined from CT scans. Both physical global score assessed...
Abstract Introduction Immune checkpoint inhibitors (ICIs) offer substantial benefits for older adults with lung cancer (LCa) but they also pose risks of immune-related adverse events (irAEs), necessitating investigation into the demographic influences on hospitalization rates. Sex differences among within this cohort are understudied. Our study aims to explore gender in irAE-related hospitalizations adults. Methods We utilized Surveillance, Epidemiology, and End Results (SEER)-linked...
Racial disparities exist in prostate cancer (PCa) care and outcomes. Ultrasound-guided biopsy may miss a significant portion of clinically PCa while magnetic resonance imaging (MRI) improves its detection. This study aims to investigate demographic SES factors influencing MRI utilization for